Genetic variation study of 12 X chromosomal STR in central Thailand population

Abstract

Genetic data from 12 short tandem repeats (STR) on the X chromosome are currently used in forensics studies to resolve issues related to complex kinship or when data is missing or ambiguous. In this study, we genotyped these 12 X chromosome STR in DNA collected from individuals from central Thailand (n = 391, 282 men and 109 women) and used this information to calculate allele and haplotype frequencies as well as forensic parameters for kinship calculations. Polymorphism information contents of the loci were range from 0.5283–0.9247, and powers of discrimination in females and males were 0.7666–0.9905 and 0.6085–0.9291, respectively. A diallelic pattern was observed at the locus DXS7132. Moreover, a comparison of genetic distance revealed a close relationship within Asian countries. Our results indicate that the X chromosomal short tandem repeat (X-STR) multiplex system provides highly informative genetic data and could be advantageous in forensic studies.

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Correspondence to Kornkiat Vongpaisarnsin.

Ethics declarations

The ethical considerations in this study were approved by The Institutional Review Board of the Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, IRB No. 190/58.

Funding

This research was supported by the Ratchadapiseksompotch Fund, Faculty of Medicine, Chulalongkorn University, grant no. RA58/092.

Conflict of interest

The authors declare that they have no competing interests.

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Vongpaisarnsin, K., Boonlert, A., Rasmeepaisarn, K. et al. Genetic variation study of 12 X chromosomal STR in central Thailand population. Int J Legal Med 130, 1497–1499 (2016). https://doi.org/10.1007/s00414-016-1363-y

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Keywords

  • X chromosome
  • Short tandem repeat
  • Central Thailand
  • Haplotype
  • Linkage disequilibrium