Alleles at the D7S820 STR locus have 6–14 different numbers of a four-nucleotide (GATA) repeat motif arranged in tandem. The D7S820 tri-allelic pattern is rare and has not been reported in the Chinese population. In this study we report a three-banded pattern at the D7S820 locus observed in a Chinese family, in which four family members in two generations had tri-allelic D7S820 genotype 10-11-12 and one family member had an abnormal bi-allele genotype 10–11. All of the four tri-allelic cases had the genotype 10-11-12, probably due to three copies of the D7S820 STR sequence in all cells (Type 2 tri-allelic pattern), and deduced alleles 10–11 were a linked inheritance in this family.
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Thiede C, Florek M, Bornhauser M, Ritter M, Mohr B, Brendel C, Ehninger G, Neubauer (1999) A Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection. Bone Marrow Transplant 23:1055–1060
Thiede C, Bornhauser M, Ehninger G (2004) Evaluation of STR informativity for chimerism testing–comparative analysis of 27 STR systems in 203 matched related donor recipient pairs. Leukemia 18:248–254
Krenke BE, Tereba A, Anderson SJ, Buel E, Culhane S, Finis CJ, Tomsey CS, Zachetti JM, Masibay A, Rabbach DR, Amiott EA, Sprecher CJ (2002) Validation of a 16-locusfluorescent multiplex system. J Forensic Sci 47:773–785
Khan F, Agarwal A, Agrawal S (2004) Significance of chimerism in hematopoietic stem cell transplantation: new variations on an old theme. Bone Marrow Transplant 34(1):1–12
Lins AM, Micka KA, Sprecher CJ, Taylor JA, Bacher JW, Rabbach D, Bever RA, Creacy S, Schumm JW (1998) Development and population study of an eight-locus short tandem repeat (STR) multiplex system. J Forensic Sci 43(6):1168–1180
Freeman JL, Perry GH, Feuk L, Redon R, McCarroll SA, Altshuler DM, Aburatani H, Jones KW, Tyler-Smith C, Hurles ME, Carter NP, Scherer SW, Lee C (2006) Copy number variation: new insights in genome diversity. Genome Res 16:949–961
Clayton TM, Guest JL, Urquhart AJ, Gill PD (2004) A genetic basis for anomalous band patterns encountered during DNA STR profiling. J Forensic Sci 49:1207–1214
Butler JM, Decker AE, Kline MC, Vallone PM (2005) Chromosomal duplications along the Y-chromosome and their potential impact on Y-STR interpretation. J Forensic Sci 50(4):853–859
This article presents independent research funded by the Shanghai Tissuebank Biotechnology Co.,LTD and supported by the Tianjin Hematonosis Hospital Hematology Department. The views expressed are those of the author(s).
This study complies with the current laws and ethical standards required in China.
Conflict of interest
The authors declare that they have no conflict of interest.
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Jiang, E., Pan, J., Han, M. et al. Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family. Int J Legal Med 130, 23–26 (2016). https://doi.org/10.1007/s00414-015-1166-6
- Tri-allelic patterns
- DNA typing
- Short tandem repeat (STR)
- D7S820 locus