Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family


Alleles at the D7S820 STR locus have 6–14 different numbers of a four-nucleotide (GATA) repeat motif arranged in tandem. The D7S820 tri-allelic pattern is rare and has not been reported in the Chinese population. In this study we report a three-banded pattern at the D7S820 locus observed in a Chinese family, in which four family members in two generations had tri-allelic D7S820 genotype 10-11-12 and one family member had an abnormal bi-allele genotype 10–11. All of the four tri-allelic cases had the genotype 10-11-12, probably due to three copies of the D7S820 STR sequence in all cells (Type 2 tri-allelic pattern), and deduced alleles 10–11 were a linked inheritance in this family.

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This article presents independent research funded by the Shanghai Tissuebank Biotechnology Co.,LTD and supported by the Tianjin Hematonosis Hospital Hematology Department. The views expressed are those of the author(s).

Ethical standards

This study complies with the current laws and ethical standards required in China.

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The authors declare that they have no conflict of interest.

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Correspondence to Zhongzheng Zheng.

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Jiang, E., Pan, J., Han, M. et al. Tri-allelic patterns at the D7S820 locus detected in two generations of a Chinese family. Int J Legal Med 130, 23–26 (2016).

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  • Tri-allelic patterns
  • DNA typing
  • Short tandem repeat (STR)
  • D7S820 locus