Models and implementation for relationship problems with dropout
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Allelic dropout in relationship problems may commonly appear in areas such as disaster victim identification and the identification of missing persons. If dropout is not accounted for, the results may be incorrect interpretation of profiles, loss of valuable information and biased results. In this paper, we explore different models for dropout in kinship cases and present an efficient implementation for one of the models. The implementation allows for dropout to be handled simultaneously with phenomena like silent alleles and mutations that may also cause discordances in relationship data, in addition to subpopulation correction. The implemented dropout model is freely available in the new version of the Familias software. The concepts and methods are illustrated on real and simulated data.
KeywordsKinship Allelic dropout Likelihood ratio Forensics DNA
GD and TE have received funding support from the European Union Seventh Framework Programme, EUROFORGEN-NoE (FP7/2007-2013) under grant agreement no. 285487.
- 2.Balding DJ (2013) Evaluation of mixed-source, low-template DNA profiles in forensic science , Proceedings of the National Academy of Sciences of the United States of America, vol 110(30), pp 12241–12246, DOI http://10.1073/pnas.1219739110
- 7.Gill P, Gusmão L, Haned H, Mayr W, Morling N, Parson W, Prieto L, Prinz M, Schneider H, Schneider P, Weir B (2012) DNA commission of the International Society of Forensic Genetics: Recommendations on the evaluation of STR typing results that may include drop-out and/or drop-in using probabilistic methods. Forensic Sci Int Genetics 6(6):679–688. doi: 10.1016/j.fsigen.2012.06.002 CrossRefGoogle Scholar
- 9.Kling D, Tilmar A, Egeland T (2014) Familias 3-extensions and new funcionality. Forensic Sci Int Genetics. doi: 10.1016/j.fsigen.2014.07.004
- 11.Mulero JJ, Chang CW, Lagace RE, Wang DY, Bas JL, McMahon TP, Hennessy LK (2008) Development and validation of the AmpFlSTR (R) MiniFiler (TM) PCR amplification kit: A MiniSTR multiplex for the analysis of degraded and/or PCR inhibited DNA. J Forensic Sci 53(4):838–852. doi: 10.1111/j.1556-4029.2008.00760.x
- 14.Sprecher CJ, McLaren RS, Rabbach D, Krenke B, Ensenberger MG, Fulmer PM, Downey L, McCombs E, Storts DR (2009) Powerplex®;ESX and ESI systems: a suite of new STR systems designed to meet the changing needs of the DNA-typing community. Forensic Sci Int: Genetics Supplement Series 2(1):2–4. doi: 10.1016/j.fsigss.2009.08.058 Google Scholar