Severe generalised rhabdomyolysis with fatal outcome associated with isotretinoin


Isotretinoin is considered to be a safe and effective therapy in otherwise therapy-resistant acne. Elevated serum creatine phosphokinase values with or without muscle-related symptoms in isotretinoin-treated patients have been reported and interpreted as benign phenomena, lethal cases have not been described yet. We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.

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Correspondence to Benno Hartung.

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Hartung, B., Merk, H.F., Huckenbeck, W. et al. Severe generalised rhabdomyolysis with fatal outcome associated with isotretinoin. Int J Legal Med 126, 953–956 (2012).

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  • Isotretinoin
  • Adverse drug reaction
  • Muscle pain
  • Rhabdomyolysis
  • Myocytolysis