International Journal of Legal Medicine

, Volume 126, Issue 6, pp 953–956 | Cite as

Severe generalised rhabdomyolysis with fatal outcome associated with isotretinoin

  • Benno HartungEmail author
  • Hans F. Merk
  • Wolfgang Huckenbeck
  • Thomas Daldrup
  • Eva Neuen-Jacob
  • Stefanie Ritz-Timme
Case Report


Isotretinoin is considered to be a safe and effective therapy in otherwise therapy-resistant acne. Elevated serum creatine phosphokinase values with or without muscle-related symptoms in isotretinoin-treated patients have been reported and interpreted as benign phenomena, lethal cases have not been described yet. We present the case of a 20-year-old male who died from severe generalised rhabdomyolysis associated with isotretinoin treatment.


Isotretinoin Adverse drug reaction Muscle pain Rhabdomyolysis Myocytolysis 


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Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • Benno Hartung
    • 1
    Email author
  • Hans F. Merk
    • 2
  • Wolfgang Huckenbeck
    • 1
  • Thomas Daldrup
    • 1
  • Eva Neuen-Jacob
    • 1
  • Stefanie Ritz-Timme
    • 1
  1. 1.University Hospital DuesseldorfDuesseldorfGermany
  2. 2.University Hospital AachenAachenGermany

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