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Use of X-linked markers for forensic purposes

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Abstract

In forensic science, X-chromosomal short tandem repeats (ChrX STRs) bear the potential to efficiently complement the analysis of other genetic markers (autosomal, Y-chromosomal or mitochondrial). We review the population genetic properties and forensic utility of selected ChrX markers, and discuss the problems and limitations arising with their practical use. Formulae required to assess the evidential power of individual markers in different contexts are summarised and applied to ChrX STRs of interest. Since linkage and linkage disequilibrium between markers affect the inferential interpretation of genotype data, practically relevant information regarding the co-localisation and haplotypic association of ChrX STRs is provided. Finally, two examples of complex kinship testing are presented which serve to highlight the particular importance of ChrX STRs for solving deficiency cases and cases involving blood relatives.

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Authors and Affiliations

  1. Institut für Rechtsmedizin, Otto-von-Guericke-Universität Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany

    R. Szibor & D. Krause

  2. Institut für Medizinische Informatik und Statistik, Christian-Albrechts-Universität Kiel, Brunswiker Strasse 10, 24105 Kiel, Germany

    M. Krawczak

  3. Institut für Rechtsmedizin, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany

    S. Hering

  4. Institut für Rechtsmedizin, Universität Leipzig, Johannisalle 28, 04103 Leipzig, Germany

    J. Edelmann

  5. Institut für Medizinische Informatik und Biometrie, Technische Universität Dresden, Fetscherstrasse 74, 01307 Dresden, Germany

    E. Kuhlisch

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  1. R. Szibor
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  2. M. Krawczak
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  3. S. Hering
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  4. J. Edelmann
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  5. E. Kuhlisch
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Szibor, R., Krawczak, M., Hering, S. et al. Use of X-linked markers for forensic purposes. Int J Legal Med 117, 67–74 (2003). https://doi.org/10.1007/s00414-002-0352-5

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  • DOI: https://doi.org/10.1007/s00414-002-0352-5

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