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Concentration of collagen cross-links in human dentin bears no relation to the individual age

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International Journal of Legal Medicine Aims and scope Submit manuscript

Abstract.

Lysylpyridinoline (LP) and hydroxylysylpyridinoline (HP) are collagen cross-link residues. HP is present in most tissues, whereas LP is specific for bone and dentin. Based on the current literature there are certain indications that measurement of the concentrations of HP and LP in dentin may be a valuable tool to determine the individual age. The purpose of this investigation was to assess if the concentrations of LP and HP in dentin increase during lifetime. We have investigated 173 molars from 173 individuals (2 through 78 years of age, 31 primary and 142 secondary teeth) in the course of the present study. Levels of LP and HP were measured by HPLC and fluorescence detection. The results show that dentinal concentrations of HP and LP did not increase with age and varied between individuals of the same age and that determination of dentinal concentrations of HP and LP cannot be used to determine the individual age.

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Authors and Affiliations

  1. Deptartment of Oral and Maxillofacial Surgery, University of Kiel, Arnold-Hellerstrasse 16, 24105 Kiel, Germany, , , , ,

    Y. Açil,  I. Springer &  J. Prasse

  2. Institute of Medical Informatics and Statistics, University of Kiel, , , , ,

    J. Hedderich

  3. Department of Conservative Dentistry and Periodontology, University of Kiel, , , , ,

    S. Jepsen

Authors
  1. Y. Açil
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  2. I. Springer
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  3. J. Prasse
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  4. J. Hedderich
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  5. S. Jepsen
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Açil, .Y., Springer, .I., Prasse, .J. et al. Concentration of collagen cross-links in human dentin bears no relation to the individual age. Int J Legal Med 116, 340–343 (2002). https://doi.org/10.1007/s00414-002-0333-8

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  • DOI: https://doi.org/10.1007/s00414-002-0333-8

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