Chromosoma

, Volume 125, Issue 2, pp 277–286 | Cite as

Back to the roots: segregation of univalent sex chromosomes in meiosis

  • Gunar Fabig
  • Thomas Müller-Reichert
  • Leocadia V. Paliulis
Review

Abstract

In males of many taxa, univalent sex chromosomes normally segregate during the first meiotic division, and analysis of sex chromosome segregation was foundational for the chromosome theory of inheritance. Correct segregation of single or multiple univalent sex chromosomes occurs in a cellular environment where every other chromosome is a bivalent that is being partitioned into homologous chromosomes at anaphase I. The mechanics of univalent chromosome segregation vary among animal taxa. In some, univalents establish syntelic attachment of sister kinetochores to the spindle. In others, amphitelic attachment is established. Here, we review how this problem of segregation of unpaired chromosomes is solved in different animal systems. In addition, we give a short outlook of how mechanistic insights into this process could be gained by explicitly studying model organisms, such as Caenorhabditis elegans.

Keywords

Male meiosis Univalent chromosomes Sex chromosomes Nematodes C. elegans Chromosome segregation 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Gunar Fabig
    • 1
  • Thomas Müller-Reichert
    • 1
  • Leocadia V. Paliulis
    • 2
  1. 1.Experimental Center, Faculty of Medicine Carl Gustav CarusTechnische Universität DresdenDresdenGermany
  2. 2.Biology DepartmentBucknell UniversityLewisburgUSA

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