Skip to main content
Log in

Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation

  • Review
  • Published:
Chromosoma Aims and scope Submit manuscript

Abstract

Meiosis is a specialised cell division process for generating gametes. In contrast to mitosis, meiosis involves recombination followed by two consecutive rounds of cell division, meiosis I and II. A vast field of research has been devoted to understanding the differences between mitotic and meiotic cell divisions from the viewpoint of chromosome behaviour. For faithful inheritance of paternal and maternal genetic information to offspring, two events are indispensable: meiotic recombination, which generates a physical link between homologous chromosomes, and reductional segregation, in which homologous chromosomes move towards opposite poles, thereby halving the ploidy. The cytoskeleton and its regulators play specialised roles in meiosis to accomplish these divisions. Recent studies have shown that microtubule-associated proteins (MAPs), including tumour overexpressed gene (TOG), play unique roles during meiosis. Furthermore, the conserved mitotic protein kinase Polo modulates MAP localisation in meiosis I. As Polo is a well-known regulator of reductional segregation in meiosis, the evidence suggests that Polo constitutes a plausible link between meiosis-specific MAP functions and reductional segregation. Here, we review the latest findings on how the localisation and regulation of MAPs in meiosis differ from those in mitosis, and we discuss conservation of the system between yeast and higher eukaryotes.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

Download references

Acknowledgments

We thank Frank Uhlmann, Takashi Toda and Masayuki Yamamoto for the support.

Funding

M.S. is supported by Grants-in-Aid for Scientific Research (B) from the Japan Society for Promotion of Science (JSPS), by the Naito Foundation, by the Kato Memorial Bioscience Foundation, by the Sumitomo Foundation and by Waseda University Grants for Special Research Projects (2014K-6168, 2014B-318 and 2015A-057). Y.K. is supported by JSPS Postdoctoral Fellowships for Research Abroad.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Yasutaka Kakui or Masamitsu Sato.

Additional information

This article is part of a Special Issue on "Recent advances in meiotic chromosome structure, recombination and segregation” edited by Marco Barchi, Paula Cohen and Scott Keeney.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kakui, Y., Sato, M. Differentiating the roles of microtubule-associated proteins at meiotic kinetochores during chromosome segregation. Chromosoma 125, 309–320 (2016). https://doi.org/10.1007/s00412-015-0541-x

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00412-015-0541-x

Keywords

Navigation