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Emerging Roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?

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Abstract

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are a highly conserved family of RNA-binding proteins able to associate with nascent RNAs in order to support their localization, maturation and translation. Research over this last decade has remarked the importance of gene regulatory processes at post-transcriptional level, highlighting the emerging roles of hnRNPs in several essential biological events. Indeed, hnRNPs are key factors in regulating gene expression, thus, having a number of roles in many biological pathways. Moreover, failure of the activities catalysed by hnRNPs affects various biological processes and may underlie several human diseases including cancer, diabetes and neurodegenerative syndromes. In this review, we summarize some of hnRNPs’ roles in the model organism Drosophila melanogaster, particularly focusing on their participation in all aspects of post-transcriptional regulation as well as their conserved role and involvement in the aetiology of human pathologies.

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Acknowledgments

We would like to thank Giulia D’Angelo for the critical reading and feedbacks on this manuscript. We would also like to apologize to all our colleagues whose work was not properly cited due to space restriction. L.L.P. is supported by an AIRC fellowship. This work was supported by grants from Fondazione Telethon, AIRC and Progetto Bandiera Epigen to D.F.V.C and by MFAG grant from AIRC to M.C.O.

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The authors declare no conflict of interest.

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  1. Dipartimento STEBICEF, Istituto Telethon Dulbecco c/o Universita’ degli Studi di Palermo, 90128, Palermo, Italy

    Luca Lo Piccolo, Davide Corona & Maria Cristina Onorati

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  1. Luca Lo Piccolo
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  2. Davide Corona
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  3. Maria Cristina Onorati
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Correspondence to Maria Cristina Onorati.

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Piccolo, L.L., Corona, D. & Onorati, M.C. Emerging Roles for hnRNPs in post-transcriptional regulation: what can we learn from flies?. Chromosoma 123, 515–527 (2014). https://doi.org/10.1007/s00412-014-0470-0

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