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Regulation of ISWI chromatin remodelling activity

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Abstract

The packaging of the eukaryotic genome into chromatin facilitates the storage of the genetic information within the nucleus, but prevents the access to the underlying DNA sequences. Structural changes in chromatin are mediated by several mechanisms. Among them, ATP-dependent remodelling complexes belonging to ISWI family provides one of the best examples that eukaryotic cells evolved to finely regulate these changes. ISWI-containing complexes use the energy derived from ATP hydrolysis to rearrange nucleosomes on chromatin in order to favour specific nuclear reactions. The combination of regulatory nuclear factors associated with the ATPase subunit as well as its modulation by specific histone modifications, specializes the nuclear function of each ISWI-containing complex. Here we review the different ways by which ISWI enzymatic activity can be modulated and regulated in the nucleus of eukaryotic cells.

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Acknowledgments

We thank our colleagues Giosalba Burgio, Roberta Sanfilippo, Maria Cristina Onorati, Luca Lo Piccolo and Vincenzo Cavalieri for their critical reading of the manuscript. We also acknowlege the support of Fondazione Telethon, AIRC, MIUR-CNR EPIGEN and EMBO YIP to DFVC. MT was supported by a FIRC Fellowship. Finally, we apologize to all our colleagues whose work was not properly cited due to space restriction.

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  1. Dulbecco Telethon Institute, c/o Dipartimento STEBICEF, Università di Palermo, Viale delle Scienze, Edificio 16, 90128, Palermo, Italy

    Maria Toto, Giulia D’Angelo & Davide F. V. Corona

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  1. Maria Toto
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  2. Giulia D’Angelo
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  3. Davide F. V. Corona
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Correspondence to Davide F. V. Corona.

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M. Toto and G. D'Angelo contributed equally to this review.

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Toto, M., D’Angelo, G. & Corona, D.F.V. Regulation of ISWI chromatin remodelling activity. Chromosoma 123, 91–102 (2014). https://doi.org/10.1007/s00412-013-0447-4

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  • DOI: https://doi.org/10.1007/s00412-013-0447-4

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