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Quality control of mRNP in the nucleus

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Abstract

Formation of functional mRNA–protein particles requires a plethora of nuclear cotranscriptional and posttranscriptional RNA processing and packaging steps. Faithful execution of these events is closely monitored by surveillance systems that prevent nuclear export of, and/or rapidly degrade, faulty transcripts. Parts of this quality control also serve to eliminate a large number of noncoding RNAs produced by RNA polymerase II. Here, we discuss which aberrant features trigger messenger ribonucleoprotein quality control, how the process is executed, and how it is connected to the transcription machinery and the nuclear pore complex.

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Acknowledgments

We thank Pascal Preker and Francisco Malagon for critical reading of the manuscript, three anonymous referees for their valuable input, and Domenico Libri for sharing unpublished data. The work was supported by the Danish National Research Foundation (Grundforskningsfonden) and the Novo Nordisk Foundation. MS is the recipient of a Human Frontier Science Program long-term fellowship.

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  1. Centre for mRNP Biogenesis and Metabolism, Department of Molecular Biology, University of Aarhus, C.F. Møllers Alle, Bldg. 130, 8000, Aarhus C, Denmark

    Manfred Schmid & Torben Heick Jensen

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  1. Manfred Schmid
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Correspondence to Manfred Schmid or Torben Heick Jensen.

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Communicated by E.A. Nigg

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Schmid, M., Jensen, T.H. Quality control of mRNP in the nucleus. Chromosoma 117, 419–429 (2008). https://doi.org/10.1007/s00412-008-0166-4

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