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Radiation and Environmental Biophysics

, Volume 38, Issue 4, pp 249–259 | Cite as

The track structures of ionizing particles and their application to radiation biophysics

II. Results for various organisms irradiated with protons, deuterons and alpha-particles
  • P. E. Briden
  • P. D. Holt
  • J. A. Simmons
Original Paper
  • 32 Downloads

Abstract 

Using knowledge of the track structure generated by ionizing particles together with details of the organisms being irradiated, the application of a new analytical method to two biophysical models to explain the inactivation of cells by radiation has been developed. It is shown that both models are equally successful in predicting experimental results and that good agreement is found with the data for single-strand phage, Bacillus subtilis spores, various strains of Escherichia coli, haploid and diploid yeast, and human diploid fibroblasts. The only significant discrepancy arose with T1-phage, for which a tentative explanation is offered. The differences in inherent radiosensitivity between organisms, after allowance is made for differences in target size, are attributed to differences in enzymatic repair systems and in the packing of the DNA.

Key words Alpha-particle Deuteron Proton Biophysical modelling Radiosensitivity Bacillus subtilis Haploid yeast Human diploid fibroblasts DNA repair systems 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1999

Authors and Affiliations

  • P. E. Briden
    • 1
  • P. D. Holt
    • 1
  • J. A. Simmons
    • 2
  1. 1.AEA Technology, Harwell Laboratory, Didcot, Oxon OX11 ORA, UKGB
  2. 2.School of Computer Science, University of Westminster (formerly Polytechnic of Central London), 115 New Cavendish Street, London W1M 8JS, UKGB

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