Radiation and Environmental Biophysics

, Volume 37, Issue 2, pp 95–100 | Cite as

Investigation of lipid peroxidation in liposomes induced by heavy ion irradiation

  • C. Ziegler
  • J. M. Wessels


Lipid peroxidation induced by heavy ion irradiation was investigated in 1,2-dilinoleoyl-sn-glycero-3-phosphocholine (DLPC) liposomes. Lipid peroxidation was induced using accelerated heavy ions that exhibit linear energy transfer (LET) values between 30 and 15 000 keV/μm and doses up to 100 kGy. With increasing LET, the formation of lipid peroxidation products such as conjugated dienes, lipid hydroperoxides, and thiobarbituric acid-reactive substances decreased. When comparing differential absorption spectra and membrane fluidity following irradiation with heavy ions and x-rays (3 Gy/min), respectively, it is obvious that there are significant differences between the influences of densely and sparsely ionizing radiation on liposomal membranes. Indications for lipid fragmentation could be detected after heavy ion irradiation.


Lipid Absorption Spectrum Lipid Peroxidation Energy Transfer Membrane Fluidity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • C. Ziegler
    • 1
  • J. M. Wessels
    • 2
  1. 1.Experimentalphysik III, Fachbereich 18, Gesamthochschule Kassel, Postfach 101380, D-34109 Kassel, GermanyDE
  2. 2.GSF – National Research Center for Environment and Health, D-85764 Neuherberg, GermanyDE

Personalised recommendations