Abstract
This article aims at comparing reference methods for the assessment of cancer risk from exposure to genotoxic carcinogen chemical substances and to ionizing radiation. For chemicals, cancer potency is expressed as a toxicological reference value (TRV) based on the most sensitive type of cancer generally observed in animal experiments of oral or inhalation exposure. A dose–response curve is established by modelling experimental data adjusted to apply to human exposure. This leads to a point of departure from which the TRV is derived as the slope of a linear extrapolation to zero dose. Human lifetime cancer risk can then be assessed as the product of dose by TRV and it is generally considered to be tolerable in a 10–6–10–4 range for the public in a normal situation. Radiation exposure is assessed as an effective dose corresponding to a weighted average of energy deposition in body organs. Cancer risk models were derived from the epidemiological follow-up of atomic bombing survivors. Considering a linear-no-threshold dose-risk relationship and average baseline risks, lifetime nominal risk coefficients were established for 13 types of cancers. Those are adjusted according to the severity of each cancer type and combined into an overall indicator denominated radiation detriment. Exposure to radiation is subject to dose limits proscribing unacceptable health detriment. The differences between chemical and radiological cancer risk assessments are discussed and concern data sources, extrapolation to low doses, definition of dose, considered health effects and level of conservatism. These differences should not be an insuperable impediment to the comparison of TRVs with radiation risk, thus opportunities exist to bring closer the two types of risk assessment.
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28 September 2021
A Correction to this paper has been published: https://doi.org/10.1007/s00411-021-00943-5
Abbreviations
- ANSES:
-
French Agency for Food, Environmental and Occupational Health & Safety
- ATSDR:
-
Agency for toxic substances and disease registry (USA)
- BMD:
-
Benchmark dose
- BMDL:
-
Lower limit of the confidence interval of the benchmark dose
- CERCLA:
-
Comprehensive Environmental Response, Compensation, and Liability Act
- DDREF:
-
Dose and dose-rate effectiveness factor
- EAR:
-
Excess absolute risk
- ECHA:
-
European Chemicals Agency
- EFSA:
-
European Food Safety Authority
- ERR:
-
Excess relative risk
- Gy:
-
Gray
- HCPH:
-
French High Council for Public Health
- ICRP:
-
International Commission on Radiological Protection
- LOAEL:
-
Lower observed adverse effect level
- LNT:
-
Linear-no-threshold
- LSS:
-
Life Span Study
- OEHHA:
-
Office of Environmental Health Hazard Assessment (USA)
- PBPK:
-
Physiologically based pharmacokinetic
- POD:
-
Point of departure
- REIC:
-
Risk of exposure-induced cancer
- RIVM:
-
National Institute for Public Health and the Environment (Netherlands)
- Sv:
-
Sievert
- TRV:
-
Toxicological reference values
- UNSCEAR:
-
United Nations Scientific Committee on the Effects of Atomic Radiation
- US-EPA:
-
United States Environmental Protection Agency
- WHO:
-
World Health Organization
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Acknowledgements
The authors are grateful to Caroline Ringeard for participating in initiating this project, and Dominique Laurier, Chrystelle Ibanez and Dmitri Klokov of the IRSN for sharing their expertise.
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Cléro, E., Bisson, M., Nathalie, V. et al. Cancer risk from chronic exposures to chemicals and radiation: a comparison of the toxicological reference value with the radiation detriment. Radiat Environ Biophys 60, 531–547 (2021). https://doi.org/10.1007/s00411-021-00938-2
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DOI: https://doi.org/10.1007/s00411-021-00938-2