This population-based ecological study analyzes the prevalence of childhood leukemia in Ukraine before and after the Chornobyl nuclear power plant accident, based on the contamination status of the territory, time period, gender, and age. Three regions—Zhytomyr, Kyiv (except Kyiv city), and Chernihiv were included as areas contaminated by radioactive 137Cs from 1 to 15 Ci/km2 with annual effective doses exceeding 1.0 mSv, and Sumy region as the control (non-contaminated) area with 137Cs contamination less than 1 Ci/km2 and effective doses less than 0.5 mSv per year. The integrated database of the National Research Centre for Radiation Medicine used in the present study included 1085 childhood leukemia cases. Two aggregated periods were used for analysis: 1980−1986 (pre-accident) and 1987−2000 (post-accident). ICD-9 codes for leukemia (204−208.9) were used to perform analyses according to the extent of leukemic cells maturity (acute, chronic, and maturity unspecified leukemia), leukemic cell lineage (lymphoid, myeloid and lineage unspecified leukemia) and all leukemia cases in different age subgroups (1−4, 5−9, 10−14, and 15−19 years). Standard methods of descriptive epidemiology were used to calculate the prevalence of disease and frequency ratio in regression models. A statistically significant increase in frequency ratio for acute leukemia (1.44; 95% confidence interval (CI), 1.22−1.71), myeloid leukemia (2.93; 95% CI, 1.71−5.40), cell lineage unspecified leukemia (II) (1.48; 95% CI, 1.18−1.87) and all forms of leukemia (1.59; 95% CI, 1.36−1.86) was found for the post-accident period in highly contaminated areas. The results indicate that the frequency of childhood leukemia (and of some of its types) increased in contaminated areas during the post-accident period, suggesting that radiation exposure after the Chornobyl accident might be the cause of the increase. However, further analytical studies, with individual or at least group dose estimates, are needed to confirm a link between childhood leukemia and the Chornobyl accident.
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Auvinen A, Hakama M, Arvela H, Hakulinen T, Rahola T, Suomela M, Söderman B, Rytömaa T (1994) Fallout from Chernobyl and incidence of childhood leukaemia in Finland, 1976–92. Br Med J 309:151–154
Bebeshko VG, Bruslova EM, Klimenko VI, Dyagil IS, Drozdova VD (1997) Leukemias and lymphomas in Ukraine population exposed to chronic low dose irradiation. Low doses of ionizing radiation: biological effects and regulatory control contributed papers. In: International conference, Seville, Spain. IAEA-TECDOC-976, pp 337–338
Belson M, Kingsley B, Holmes A (2007) Risk factors for acute leukemia in children: a review. Environ Health Perspect 115(1):138–145
Boice J (1996) Cancer following irradiation in childhood and adolescence. Med Pediatric Oncol (Suppl) 1:29–34
Cardis E, Howe G, Ron E, Bebeshko V, Bogdanova T, Bouville A, Carr Zh, Chumak V, Davis S, Demidchik Yu, Drozdovitch V, Gentner N, Gudzenko N, Hatch M, Ivanov V, Jacob P, Kapitonova Eleonora, Kenigsberg Y, Kesminiene A, Kopecky KJ, Kryuchkov V, Loos A, Pinchera A, Reiners Ch, Repacholi M, Yo Shibata, Shore RE, Thomas G, Tirmarche M, Yamashita Sh, Zvonova I (2006) Cancer consequences of the Chernobyl accident: 20 years on (review). J Radiol Prot 26(2):127–140
Davies A, Modan B, Djaldetti M, deVries A (1961) Epidemiological observations on leukemia in Israel. Arch Intern Med 108:86–90
Davis S, Day RW, Kopecky KJ (2006) Childhood leukaemia in Belarus, Russia, and Ukraine following the Chernobyl power station accident: results from an international collaborative population-based case–control study. Int J Epidemiol 35(2):386–396
Gapanovich VN, Iaroshevich RF, Shuvaeva LP, Becker SI, Nekolla EA, Kellerer AM (2001) Childhood leukemia in Belarus before and after the Chernobyl accident: continued follow-up. Radiat Environ Biophys 40:259–267
Gunay U, Meral A, Sevinir B (1996) Pediatric malignancies in Bursa, Turkey. J Environ Pathol Toxicol Oncol 15:263–265
Hatch M, Ostroumova E, Brenner A, Federenko Z, Gorokh Y, Zvinchuk O, Shpak V, Tereschenko V, Tronko M, Mabuchi K (2015) Non-thyroid cancer in Northern Ukraine in the post-Chernobyl period: short Report. Cancer Epidemiol 39(3):279–283
Hjalmars U, Kulldorff M, Gustafsson G (1994) Risk of acute childhood leukemia in Sweden after the Chernobyl reactor accident. Br Med J 309:154–157
Ivanov EP, Tolochko GV, Lazarev VS, Shuvaeva L (1993) Child leukaemia after Chernobyl. Nature 365:702
Ivanov EP, Tolochko GV, Shuvaeva LP, Becker S, Nekolla E, Kellerer AM (1996) Childhood leukemia in Belarus before and after the Chernobyl accident. Radiat Environ Biophys 35(2):75–80
Ivanov EP, Tolochko GV, Shuvaeva LP, Ivanov VE, Iaroshevich RF, Becker S, Nekolla E, Kellerer AM (1998) Infant leukemia in Belarus after the Chernobyl accident. Radiat Environ Biophys 37:53–55
Kendall GM, Little MP, Wakeford R, Wakeford R, Bunch KJ, Miles JCH, Vincent TJ, Meara JR, Murphy MFG (2013) A record-based case–control study of natural background radiation and the incidence of childhood leukaemia and other cancers in Great Britain during 1980–2006. Leukemia 27:3–9
Körblein A (2013) Increased leukemia rates in children from Belarus after Chernobyl. Available: Strahlentelex mit Elektrosmog Report ISSN 0931-4288, No. 626–627, Feb 7, 2013. http://www.strahlentelex.de, English version
Lundell M, Holm L-E (1996) Mortality from leukemia after irradiation in infancy for skin hemangioma. Rad Res 145(5):595–601
Malko MV, Ivanov EP, Parkin M, Ivanov VE (2004) Chernobyl leukemia in children of Belarus Mat. of the II Int Conf “Medico-Social Ecology of Individual: Status and Perspective”. 2−3 April 2004. Ministry of Education of the Republic of Belarus. Belarusian State University, Minsk, pp 97−101 (in Russian)
Mangano J (1997) Childhood leukaemia in US might have risen due to fallout from Chernobyl. Br Med J 314:1200
Michaelis J, Kaletsch U, Burkart W, Grosche B (1997) Infant leukaemia after the Chernobyl accident [letter]. Nature 387:246
Moysich KB, Menezes RJ, Michalek AM (2002) Chernobyl-related ionising radiation exposure and cancer risk: an epidemiological review. Lancet Oncol 3(5):269–279
Murray R, Heckel P, Hempelmann L (1959) Leukemia in children exposed to ionizing radiation. N Engl J Med 261:585–589
Noshchenko AG, Moysich KB, Bondar AY (2001) Patterns of acute leukemia occurrence among children in the Chernobyl region. Int J Epidemiol 30:125–129
Noshchenko AG, Zamostyan PV, Bondar OY, Drozdova VD (2002) Radiation-induced leukemia risk among those aged 0−20 at the time of the Chernobyl accident: a case-control study in the Ukraine. Int J Cancer 99(4):609–618
Noshchenko AG, Bondar OY, Drozdova VD (2010) Radiation-induced leukemia among children age 0–5 years at the time of the Chernobyl accident. Int J Cancer 127(2):412–426
Ostroumova E, Hatch M, Brenner A, Nadyrov E, Veyalkin I, Polyanskaya O, Yauseyenka V, Polyakov S, Levin L, Zablotska L, Rozhko A, Mabuchi K (2016) Non-thyroid cancer incidence in Belarusian residents exposed to Chernobyl fallout in childhood and adolescence: standardized Incidence Ratio analysis, 1997−2011. Environ Res 147:44–49
Parkin DM, Cardis E, Masuyer E, Friedl HP, Hansluwka H, Bobev D, Ivanov E, Sinnaeve J, Augustin J, Plesko I, Storm HH, Rahu M, Karjalainen S, Bernard JL, Carli PM, L'Huillier MC, Lutz JM, Schaffer P, Schraub S, Michaelis J, Möhner M, Staneczek W, Vargha M, Crosignani P, Magnani C, Terracini B, Kriauciunas R, Coebergh JW, Langmark F, Zatonski W, Merabishvili V, Pompe-Kirn V, Barlow L, Raymond L, Black R, Stiller CA, Bennett BG (1993) Childhood leukaemia following the Chernobyl accident: the European childhood leukaemia-lymphoma incidence study (ECLIS). Eur J Cancer 29(1):87–95
Parkin DM, Clayton D, Black RJ, Masuyer E, Friedl HP, Ivanov E, Sinnaeve J, Tzvetansky CG, Geryk E, Storm HH, Rahu M, Pukkala E, Bernard JL, Carli PM, L'Huillier MC, Ménégoz F, Schaffer P, Schraub S, Kaatsch P, Michaelis J, Apjok E, Schuler D, Crosignani P, Magnani C, Terracini B, Stengrevics A, Kriauciunas R, Coebergh JW, Langmark F, Zatonski W, Tulbure R, Boukhny A, Merabishvili V, Plesko I, Krámarovát E, Pompe-Kirn V, Barlow L, Enderlin F, Levi F, Raymond L, Schiüler G, Torhorst J, Stiller CA, Sharp L, Bennett BG (1996) Childhood leukaemia in Europe after Chernobyl: 5 year follow-up. Br J Cancer 73(8):1006–1012
Petridou E, Proukakis C, Tong D, Kassimos D, Athanassiadou-Piperopoulou F, Haidas S, Kalmanti M, Koliouskas D, Kosmidis H, Louizi A et al (1994) Trends and geographical distribution of childhood leukemia in Greece in relation to the Chernobyl accident. Scand J Soc Med 22:127–131
Petridou E, Trichopoulos D, Dessypris N, Flytzani V, Haidas S, Kalmanti M, Koliouskas D, Kosmidis H, Piperopoulou F, Tzortzatou F (1996) Infant leukemia after in utero exposure to radiation from Chernobyl. Nature 382:352–353
Preston DL, Pierce DA, Shimizu Y, Cullings HM, Fujita S, Funamoto S, Kodama K (2004) Effect of recent changes in atomic bomb survivor dosimetry on cancer mortality risk estimates. Radiat Res 162(4):377–389
Prisyazhiuk AE, Pjatak OA, Buzanov VA, Reeves GK, Beral V (1991) Cancer in the Ukraine, post-Chernobyl. Lancet 338:1334–1335
Ron E (1998) Ionizing radiation and cancer risk: evidence from epidemiology. Radiat Res 150(5 Suppl):30–41
Ron E, Modan B, Boice JD (1988) Mortality after radiotherapy for ringworm of the scalp. Am J Epidemiol 127:713–725
Sali D, Cardis E, Sztanyik L, Auvinen A, Bairakova A, Dontas N, Grosche B, Kerekes A, Kusic Z, Kusoglu C, Lechpammer S, Lyra M, Michaelis J, Petridou E, Szybinski Z, Tominaga S, Tulbure R, Turnbull A, Valerianova Z (1996) Cancer consequences of the Chernobyl accident in Europe outside the former USSR: a review. Int J Cancer 67:343–352
Shu XO, Potter JD, Linet MS, Severson RK, Han D, Kersey JH, Neglia JP, Trigg ME, Robison LL (2002) Diagnostic X-rays and ultrasound exposure and risk of acute lymphoblastic leukemia by immunophenotype. Cancer Epidemiol Biomark Prev 11:177–185
State Committee of Statistics of Ukraine (1995) Newsletter of the State Statistics Committee of Ukraine/Ukraine. State Committee of Statistics (1995) Uzhgorod, “IVA”,# 3-4
Steiner M, Burkart W, Grosche B, Kaletsch U, Michaelis J (1998) Trends in infant leukemia in West Germany in relationship to in utero exposure due to Chernobyl accident. Radiat Environ Biophys 37:87–93
Tondel M, Carlsson G, Hardell L, Eriksson M, Jakobsson S, Flodin U, Sköldestig A, Axelson O (1996) Incidence of neoplasms in ages 0–19 y in parts of Sweden with high 137Cs fallout after the Chernobyl accident. Health Phys 71:947–950
Török S, Borgulya G, Lobmayer P, Jakab Z, Schuler D, Fekete G (2005) Childhood leukaemia incidence in Hungary, 1973−2002. Interpolation model for analysing the possible effects of the Chernobyl accident. Eur J Epidemiol 20(11):899–906
United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR (1988) Report to the general assembly with scientific annexes. sources and effects of ionizing radiation. http://www.unscear.org/unscear/publications.html
United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR (2000).Report to the general assembly with scientific annexes. sources and effects of ionizing radiation. Annex J, exposure and effects of the Chernobyl accident. United Nations, New York
United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR (2006). Report to the general assembly with scientific annexes. Effects of ionizing radiation. Vol. I. Report and annexes A and B. United Nations, New York
United Nations Scientific Committee on the Effects of Atomic Radiation. UNSCEAR 2008.Report to the general assembly with scientific annexes. Sources and effects of ionizing radiation. Vol. II. Annex D: Health effects due to radiation from the Chernobyl accident. United Nations, New York. Available: http://www.unscear.org/docs/reports/2008/11-80076_Report_2008_Annex_D.pdf [accessed 26 November 2012]
Wakeford R, Little MP, Kendall GM (2010) Risk of childhood leukemia after low-level exposure to ionizing radiation. Expert Rev Hematol 3(3):251–254. https://doi.org/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3076706/-_articleid959217aff-info
This study was funded by the National Research Centre for Radiation Medicine of the National Academy of Medical Sciences of Ukraine. Authors are grateful to Dr. R. Pott-Born (LMU, Munich) and Dr. M. Tirmarche (IRSN) for their help and advice in the harmonization of case data acquisition in the frame of French-German Initiative on Chornobyl.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
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Liubarets, T.F., Shibata, Y., Saenko, V.A. et al. Childhood leukemia in Ukraine after the Chornobyl accident. Radiat Environ Biophys 58, 553–562 (2019). https://doi.org/10.1007/s00411-019-00810-4
- Childhood leukemia
- Ionizing radiation
- Chornobyl accident
- Contaminated areas