Radiation and Environmental Biophysics

, Volume 56, Issue 1, pp 1–8 | Cite as

Biokinetic measurements and modelling of urinary excretion of cerium citrate in humans

  • Vera HöllrieglEmail author
  • Wei Bo Li
  • Bernhard Michalke
Original Article


Tracer kinetics in healthy human volunteers was studied applying stable isotopes of cerium citrate to obtain biokinetic human data for the urinary excretion of cerium. These data were then used to compare and validate the biokinetic model for lanthanides (cerium) proposed by Taylor and Leggett (Radiat Prot Dosim 105:193–198, 2003), which is substantially improved and more realistic than the biokinetic model currently recommended by the International Commission on Radiological Protection (ICRP Publication 67, 1993); both models are primarily based on animal data. In the present study, 16 adults were investigated and two cerium tracers were simultaneously administered, both intravenously and/or orally. The cerium concentrations in urine were determined by inductively coupled plasma mass spectrometry. Ingested cerium citrate was poorly absorbed, and its low excretion was similar to the prediction of the biokinetic model of Taylor and Leggett. In contrast, after injection of cerium citrate its urinary excretion was rapidly increased, and the model underestimated the experimental results. These results suggest that urinary excretion of cerium may be dependent on the administered chemical form of cerium (speciation).


Lanthanides Tracer study Biokinetics Compartment models Speciation 



We gratefully thank Peter Grill for the ICPMS measurements, Marianna Lucio for statistical help, and Matthias Greiter and Augusto Giussani for intense discussions. This work was supported by the German Federal Ministry of Education and Research (BMBF) with contract number 02NUK030A.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Research Unit Medical Radiation Physics and DiagnosticsGerman Research Center for Environmental Health, Helmholtz Zentrum MünchenNeuherbergGermany
  2. 2.Research Unit Analytical BioGeoChemistryGerman Research Center for Environmental Health, Helmholtz Zentrum MünchenNeuherbergGermany

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