Biokinetic measurements and modelling of urinary excretion of cerium citrate in humans
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Tracer kinetics in healthy human volunteers was studied applying stable isotopes of cerium citrate to obtain biokinetic human data for the urinary excretion of cerium. These data were then used to compare and validate the biokinetic model for lanthanides (cerium) proposed by Taylor and Leggett (Radiat Prot Dosim 105:193–198, 2003), which is substantially improved and more realistic than the biokinetic model currently recommended by the International Commission on Radiological Protection (ICRP Publication 67, 1993); both models are primarily based on animal data. In the present study, 16 adults were investigated and two cerium tracers were simultaneously administered, both intravenously and/or orally. The cerium concentrations in urine were determined by inductively coupled plasma mass spectrometry. Ingested cerium citrate was poorly absorbed, and its low excretion was similar to the prediction of the biokinetic model of Taylor and Leggett. In contrast, after injection of cerium citrate its urinary excretion was rapidly increased, and the model underestimated the experimental results. These results suggest that urinary excretion of cerium may be dependent on the administered chemical form of cerium (speciation).
KeywordsLanthanides Tracer study Biokinetics Compartment models Speciation
We gratefully thank Peter Grill for the ICPMS measurements, Marianna Lucio for statistical help, and Matthias Greiter and Augusto Giussani for intense discussions. This work was supported by the German Federal Ministry of Education and Research (BMBF) with contract number 02NUK030A.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Informed consent was obtained from all individual participants included in the study.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.
- Aeberhardt A, Nizza P, Remy J, Boilleau Y (1962) Etude comparee du métabolisme du cérium 144 en fonction de son état physico-chimique chez le rat. Int J Radiat Biol 5:217–246Google Scholar
- Gantt B, Hoque S, Willis RD, Fahey KM, Delgado-Saborit J, Harrison RM, Erdakos GB, Bhave PV, Max Zhang K, Kovalcik K, Pye HOT (2014) Near-road modeling and measurement of cerium-containing particles generated by nanoparticle diesel fuel additive use. Environ Sci Technol 48:10607–10613ADSCrossRefGoogle Scholar
- Giussani A, Cantone MC, Gerstmann U, Greiter M, Hertenberger R, Höllriegl V, Leopold K, Veronese I, Oeh U (2008) Biokinetics of ruthenium isotopes in humans and its dependence on chemical speciation. 12th International Congress of the International Radiation Protection Association. Buenos Aires, ArgentinaGoogle Scholar
- ICRP (1989) Age-dependent doses to members of the public from intake of radionuclides: Part 1: Ingestion dose coefficients. ICRP Publication 56. Pergamon Press, Oxford, UKGoogle Scholar
- ICRP (1993) Age-dependent doses to members of the public from intake of radionuclides: Part 2: Ingestion dose coefficients. ICRP Publication 67. Pergamon Press, Oxford, UKGoogle Scholar
- ICRP (2006) Human alimentary tract model for radiological protection. ICRP Publication 100. Elsevier, Oxford, UKGoogle Scholar
- ICRP (2015) Occupational intakes of radionuclides: Part 1. ICRP Publication 130. Pergamon Press, Oxford, UKGoogle Scholar
- Linsalata P, Eisenbud M, Penna Franca F (1986) Ingestion estimates of Th and the light rare earth elements based on measurements on human feces. Health Phys 50:163–167Google Scholar
- NCRP (1978) Physical, chemical, and biological properties of radiocerium relevant to radiation protection guidelines. NCRP Report 60. National Council on Radiation Protection and Measurements, NCRP Publication, Washington, DCGoogle Scholar
- Pitkevich VA, Duba VV, Ivanov VK, Chekin CY, Tsyb AF, Vakulovshi CM, Shershakov VM, Makhon KP, Golubenkov AV, Borodin RV, Kosykh VS (1996) Reconstruction of the composition of the Chernobyl radionuclide fallout and external radiation absorbed doses to the population in areas of Russia. Radiat Prot Dosim 64:69–92CrossRefGoogle Scholar
- Spencer H (1963) Metabolism and removal of some radioisotopes in man. In: Diagnosis and treatment of radioactive poisoning. Proceedings of a scientific meeting held at Vienna (A), 15–18 October 1962, jointly organized by WHO and IAEAGoogle Scholar