Use of proteomics in radiobiological research: current state of the art
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Biological systems are complex, variable and to a great extent adaptive to environmental and occupational challenge such as ionising radiation, making the mathematical modelling of their behaviour a difficult task. The required models need to be based on useful experimental data describing global effects on a cellular, tissue and organ level. High-throughput technologies such as proteomics have been shown to be powerful tools on many areas of modern biology. In radiation biology, especially facing the question of possible adverse health effects following exposures to low doses of ionising and non-ionising radiation, new and sensitive approaches are slowly gaining support.
Epidemiological studies suggest that doses of ionising radiation much lower than previously assumed may cause adverse effects on human health. However, the epidemiological approach in validating the health hazards of low-dose ionising radiation may not be sensitive enough to detect weak biological effects, nor will it...
KeywordsProteomics Approach Human Endothelial Cell Line Radiobiological Study Reverse Phase Protein Microarray Phase Protein Microarray
This article is based on the information gained from the lectures and discussions during the 1st International Radiation Proteomics Workshop held in Munich, May 27–28, 2009. We want to especially thank the scientists who authorised us to use the unpublished data mentioned in this article. Federal Office for Radiation Protection (Grant 3608S03030) and Helmholtz Zentrum München are acknowledged for their financial support to the workshop.