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Coronary heart disease mortality and radon exposure in the Newfoundland fluorspar miners’ cohort, 1950–2001

Abstract

Kreuzer and coworkers recently reported no association between cumulative exposure to radiation and death from cardiovascular disease in a cohort of German uranium miners. Here, we report on the relationship between cumulative exposure to radon progeny and coronary heart disease among Newfoundland fluorspar miners. Previous analyses in this cohort found elevated death rates from coronary heart disease among those with higher cumulative radon exposure. However, this finding was based on a relatively small number of deaths and was not statistically significant. Since then, the follow-up of this cohort has been extended by 10 years until the end of 2001. Among the 2,070 miners in our study, 267 died from coronary heart disease. There was no trend evident between cumulative exposure to radon and the relative risk of death from coronary heart disease (P = 0.63). This finding was unchanged after adjusting for the lifetime smoking status that was available for approximately 54% of the cohort. Similarly, the cumulative radon exposure was found to be unrelated to deaths of the circulatory system, acute myocardial infarction, and cerebrovascular disease. These findings are consistent with those recently reported by Kreuzer and colleagues. We share their view that uncontrolled confounding for other coronary heart disease risk factors hinders the interpretation of the risk estimates.

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References

  1. 1.

    Villeneuve PJ, Morrison HI (1997) Coronary heart disease mortality among Newfoundland fluorspar miners. Scand J Work Environ Health 23(3):221–226

    Google Scholar 

  2. 2.

    Choi BC (1992) Definition, sources, magnitude, effect modifiers, and strategies of reduction of the healthy worker effect. J Occup Med 34(10):979–988

    Google Scholar 

  3. 3.

    Preston DL, Shimizu Y, Pierce DA, Suyama A, Mabuchi K (2003) Studies of mortality of atomic bomb survivors. Report 13: solid cancer and noncancer disease mortality: 1950–1997. Radiat Res 160(4):381–407

    Article  Google Scholar 

  4. 4.

    Cardis E, Gilbert ES, Carpenter L, Howe G, Kato I, Armstrong BK, Beral V, Cowper G, Douglas A, Fix J, Fry SA, Kaldor J, Lave C, Salmon L, Smith PG, Voelz GL, Wiggs LD (1995) Effects of low doses and low dose rates of external ionizing radiation: cancer mortality among nuclear industry workers in three countries. Radiat Res 142(2):117–132

    Article  Google Scholar 

  5. 5.

    Ashmore JP, Krewski D, Zielinski JM, Jiang H, Semenciw R, Band PR (1998) First analysis of mortality and occupational radiation exposure based on the National Dose Registry of Canada. Am J Epidemiol 148(6):564–574

    Google Scholar 

  6. 6.

    McGale P, Darby SC (2005) Low doses of ionizing radiation and circulatory diseases: a systematic review of the published epidemiological evidence. Radiat Res 163(3):247–257

    Article  Google Scholar 

  7. 7.

    Kreuzer M, Kreisheimer M, Kandel M, Schnelzer M, Tschense A, Grosche B (2006) Mortality from cardiovascular diseases in the German uranium miners cohort study, 1946–1998. Radiat Environ Biophys 45(3):159–166

    Article  Google Scholar 

  8. 8.

    Villeneuve PJ, Morrison HI, Lane R (2007) Radon and lung cancer risk: an extension of the mortality follow-up of the Newfoundland fluorspar cohort. Health Phys 92(2):157–169

    Article  Google Scholar 

  9. 9.

    Windish JP, Sanderson HP (1958) Dust levels in the mines of Newfoundland. National Health and Welfare, Ottawa

  10. 10.

    Morrison HI, Semenciw RM, Mao Y, Wigle DT (1988) The mortality experience of a group of Newfoundland Fluorspar miners exposed to Rn progeny. Atomic Energy Control Board, Ottawa

  11. 11.

    Morrison HI, Semenciw RM, Mao Y (1985) Lung cancer and radiation exposure among the Newfoundland fluorspar miners. In: Stocker H (ed) Occupational radiation safety in mining. Canadian Nuclear Association, Toronto, pp 365–368

  12. 12.

    Schnatter AR, Acquavella JF, Thompson FS, Donaleski D, Theriault G (1990) An analysis of death ascertainment and follow-up through statistics Canada’s Mortality Data Base system. Can J Public Health 81(1):60–65

    Google Scholar 

  13. 13.

    Goldberg MS, Carpenter M, Theriault G, Fair M (1993) The accuracy of ascertaining vital status in a historical cohort study of synthetic textiles workers using computerized record linkage to the Canadian Mortality Data Base. Can J Public Health 84(3):201–204

    Google Scholar 

  14. 14.

    Corkill DA, Dory AB (1984) A retrospective study of radon daughter concentrations in the workplace in the fluorspar mines in St Lawrence, Newfoundland. Atomic Energy Control Board, Ottawa

  15. 15.

    SAS Institute Inc. (2003) SAS, 8.0 edn. SAS Institute Inc., Cary

  16. 16.

    Morrison HI, Villeneuve PJ, Lubin JH, Schaubel DE (1998) Radon-progeny exposure and lung cancer risk in a cohort of Newfoundland fluorspar miners. Radiat Res 150(1):58–65

    Article  Google Scholar 

  17. 17.

    Breslow NE, Day NE (1987) Statistical methods in cancer research, vol II—the design and analysis of cohort studies. IARC, Lyon

  18. 18.

    National Research Council (1999) Health effects of exposure to radon. BEIR VI. National Academies, Washington

  19. 19.

    Porstendörfer J (1994) Properties and behaviour of radon and thoron and their decay products in the air. J Aerosol Sci 25:219–63

    Article  Google Scholar 

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Acknowledgments

We thank the Occupational and Environmental Health Division at Statistics Canada, in particular Lana Marjama and Dores Zuccarini, for their assistance in linking the Newfoundland fluorspar cohort to the Canadian Mortality Data Base. The Canadian Nuclear Safety Commission provided funding support for this project.

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Correspondence to Paul J. Villeneuve.

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Villeneuve, P.J., Lane, R.S.D. & Morrison, H.I. Coronary heart disease mortality and radon exposure in the Newfoundland fluorspar miners’ cohort, 1950–2001. Radiat Environ Biophys 46, 291–296 (2007). https://doi.org/10.1007/s00411-007-0108-1

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Keywords

  • Coronary Heart Disease
  • Radon
  • Cumulative Exposure
  • Thoron
  • Coronary Heart Disease Mortality