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Radiation and Environmental Biophysics

, Volume 45, Issue 2, pp 115–124 | Cite as

Human biokinetics of strontium. Part I: Intestinal absorption rate and its impact on the dose coefficient of 90Sr after ingestion

  • Wei Bo LiEmail author
  • Vera Höllriegl
  • Paul Roth
  • Uwe Oeh
Original Paper

Abstract

Intestinal absorption of strontium (Sr) in thirteen healthy adult German volunteers has been investigated by simultaneous oral and intravenous administration of two stable tracer isotopes, i.e. 84Sr and 86Sr. The measured Sr tracer concentration in plasma was analyzed using the convolution integral technique to obtain the intestinal absorption rate. The results showed that the Sr labeled in different foodstuffs was absorbed into the body fluids in a large range of difference. The maximum Sr absorption rates were observed within 60–120 min after administration. The rate of absorption is used to evaluate the intestinal absorption fraction, i.e. the f 1 value for various foodstuffs. The equivalent and effective dose coefficients for ingestion of 90Sr were calculated using these f 1 values, and they were compared with those recommended by the International Commission on Radiological Protection (ICRP). The geometric and arithmetic means of the f 1 values are 0.38 and 0.45 associated with a geometric standard deviation and a standard deviation of 1.88 and 0.22, respectively. The 90% confidence interval of the f 1 values obtained in the present study ranges from 0.13 to 0.98. Expressed as the ratio of the 95 and 50% percentiles of the estimated probability, the uncertainty for the f 1 value corresponds to a factor of 2.58. The effective dose coefficients of 90Sr after ingestion are 6.1×10−9 Sv Bq−1 for an f1 value of 0.05, 1.0×10−8 Sv Bq−1 for 0.1, 1.9×10−8 Sv Bq−1 for 0.2, 2.8×10−8 Sv Bq−1 for 0.3, 3.6×10−8 Sv Bq−1 for 0.4, 5.3×10−8 Sv Bq−1 for 0.6, 7.1×10−8 Sv Bq−1 for 0.8, and 7.9×10−8 Sv Bq−1 for 0.9, respectively. Taking the effective dose coefficient of 2.8×10−8 Sv Bq−1 for an f 1 value of 0.3, which is recommended by the ICRP, as a reference, the effective dose coefficient of 90Sr after ingestion varies by a factor of 2.8 when the f 1 value changes by a factor of 3, i.e. it decreases from 0.3 to 0.1 or increases from 0.3 to 0.9, respectively.

Keywords

Alginate 86Sr Thermal Ionization Mass Spectrometry Baby Food Dose Coefficient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

The authors are grateful to Dr. D. Noßke for providing the nuclear transformation data, U S, of 90Sr and 90Y for comparison. We thank Dr. K.F. Eckerman for sharing his latest version of the SEECAL program. Thanks are due to the reviewers for their important and valuable comments.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • Wei Bo Li
    • 1
    Email author
  • Vera Höllriegl
    • 1
  • Paul Roth
    • 1
  • Uwe Oeh
    • 1
  1. 1.Institute of Radiation ProtectionGSF-National Research Center for Environment and HealthNeuherbergGermany

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