In this study,we explored the effect of adiposity as measured by BMI on lung function in 72 asthmatic school children (5–12 years) using baseline data from the Mediterranean diet enriched with fatty fish intervention study. Bronchial function was assessed using spirometry and fractional exhaled nitric oxide (FeNO). BMI categories were classified as normal and overweight/obese based on International Obesity Task Force cut-offs. Weak correlations were observed between BMI and FVC (p = 0.013) and FEV1 (p = 0.026). Median FeNO was lower in the overweight/obese as compared to normal weight group (p = 0.027). Linear regression showed an increment in FEF25–75% in the overweight/obese group as compared to normal weight after controlling for confounders namely age, height, sex, regular physical activity, medication and KIDMED score (p = 0.043; β = 11.65 units, 95% CI 0.36–22.94), although with no effect on FeNO. In conclusion, the findings of this study suggest that excess body weight could impact pulmonary dynamics in childhood asthma.
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Body mass index
- FEV1 :
Forced expiratory volume in 1 s
Forced vital capacity
Ratio of forced expiratory volume in 1 s and forced vital capacity
Peak expiratory flow
- FEF25–75% :
Mid expiratory flow 25–75% vital capacity
Fractional exhaled nitric oxide
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We gratefully acknowledge Basilopoulos and Sklavenitis supermarkets for the provision of coupons and fish to disadvantaged families.
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. The first author is supported by the Australian Post Graduate Award PhD Scholarship administered by La Trobe University.
Conflicts of interest
The authors declare that they have no conflict of interest.
All procedures performed in this study involving human participants were in accordance with the ethical standards of the institution (La Trobe University Human Ethics Committee, HEC 16-035) and with the 1964 Helsinki declaration and its later amendments.
Informed consent was obtained from all individual participants included in this study.
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Papamichael, M.M., Katsardis, C., Tsoukalas, D. et al. Weight Status and Respiratory Health in Asthmatic Children. Lung 197, 777–782 (2019). https://doi.org/10.1007/s00408-019-00273-w
- Body mass index
- Lung function