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Impact of Psychological Deficits and Pain on Physical Activity of Patients with Interstitial Lung Disease

  • Interstitial Lung Disease
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Abstract

Purpose

The impact of psychological deficits and pain on physical activity has not been adequately studied in patients with fibrotic interstitial lung disease (ILD). We aimed to determine the association of depression, anxiety, sleep quality, and pain with physical activity in fibrotic ILD.

Methods

Waist ActiGraph activity monitors were worn for seven consecutive days to track step counts and moderate-to-vigorous physical activity (MVPA) minutes at baseline and 6-month follow-up. Psychological deficits and pain were assessed using the Hospital Anxiety and Depression Scale, the Pittsburgh Sleep Quality Index, and the Brief Pain Inventory. Multivariable linear regression was used to determine if each deficit independently predicted physical activity when adjusted for potential confounders.

Results

A total of 111 patients were recruited, with 91 of these patients completing the 6-month follow-up. Median step count and MVPA minutes were 3853 steps/day (interquartile range 2236–6805) and 87 (17–225) min/week at baseline, respectively, with no significant changes at follow-up. Borderline or abnormal depression and anxiety scores were present in 19% and 22% of patients, respectively. Poor sleep quality and moderate-to-severe pain were present in 61% and 9% of patients. Higher depression scores were associated with fewer baseline and follow-up step counts and lower MVPA minutes at follow-up on unadjusted analysis; higher pain severity scores were associated with fewer baseline step count. Pain severity remained an independent predictor of reduced step count after adjusting for patient’s age, smoking status, ILD severity, and weather variables.

Conclusions

Pain severity may be a potentially modifiable determinant of physical activity in patients with fibrotic ILD.

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Acknowledgements

The authors would like to acknowledge the patients who allowed us to conduct this research in an effort to improve the lives of people living with ILD. We would also like to thank the providers and staff of The Lung Centre of Vancouver General Hospital and the Pacific Lung Health Centre of St. Paul’s Hospital. This work was supported by the Canadian Pulmonary Fibrosis Foundation in partnership with Hoffmann-La Roche Ltd. (EMS #E0000011930).

Funding

This project was funded by the Canadian Pulmonary Fibrosis Foundation in partnership with Hoffmann-La Roche Ltd. (EMS #E0000011930). The funding organizations were not involved in study design, data collection and analysis, interpretation of results, writing of the manuscript, or decision to submit the article for publication.

Author information

Authors and Affiliations

  1. Department of Medicine, University of British Columbia, 8B Providence, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada

    Seo Am Hur, Sabina A. Guler & Christopher J. Ryerson

  2. Centre for Heart Lung Innovation, St. Paul’S Hospital, Vancouver, BC, V6Z 1Y6, Canada

    Seo Am Hur, Sabina A. Guler, Pat G. Camp, Jordan A. Guenette & Christopher J. Ryerson

  3. Department of Pulmonary Medicine, University Hospital and University of Bern, Bern, Switzerland

    Sabina A. Guler

  4. The Lung Centre, Vancouver General Hospital, Vancouver, BC, V5Z 1M9, Canada

    Nasreen Khalil

  5. Department of Physical Therapy, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada

    Pat G. Camp & Jordan A. Guenette

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  1. Seo Am Hur
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  3. Nasreen Khalil
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  6. Christopher J. Ryerson
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Contributions

Literature search: SAH, CJR. Data collection: SAH, CJR, NK. Study design: SAH, CJR. Analysis of data: SAH, CJR, SAG, PGC, JAG. Manuscript preparation: SAH, CJR, SAG, PGC, JAG, NK. Review of manuscript: SAH, CJR, SAG, PGC, JAG, NK.

Corresponding author

Correspondence to Christopher J. Ryerson.

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The authors declare that they have no conflict of interest.

Disclosures

This work was supported by the Canadian Pulmonary Fibrosis Foundation in partnership with Hoffmann-La Roche Ltd. (EMS #E0000011930). The funding organizations were not involved in study design, data collection and analysis, interpretation of results, writing of the manuscript, or decision to submit the article for publication.

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Hur, S.A., Guler, S.A., Khalil, N. et al. Impact of Psychological Deficits and Pain on Physical Activity of Patients with Interstitial Lung Disease. Lung 197, 415–425 (2019). https://doi.org/10.1007/s00408-019-00242-3

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  • DOI: https://doi.org/10.1007/s00408-019-00242-3

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