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Cardiovascular Studies in Patients with Chronic Obstructive Pulmonary Disease Due to Biomass Smoke or Tobacco

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Abstract

Background and Objective

The cardiovascular effects of biomass smoke exposure in patients with chronic obstructive pulmonary disease are not well characterized, and few studies have assessed the possible differences between patients with disease caused by biomass smoke and tobacco. The aim of this study was to search for differences in cardiovascular variables between both types of the disease.

Methods

Twenty subjects (15 men, 5 women) with chronic obstructive pulmonary disease caused by tobacco were matched one to one for sex, age, and forced expiratory volume in 1 s to 20 patients with biomass-related disease. Echocardiography and carotid ultrasound studies were performed. Flow-mediated endothelium-dependent vasodilatation and endothelium-independent vasodilatation were also measured.

Results

There were no significant differences between groups in any of the echocardiographic variables, nor in the intima–media carotid thickness, the number of carotid plaques, or the percentage of endothelium-dependent or endothelium-independent vasodilation. A high percentage of patients in both groups showed an abnormal flow-mediated endothelium-dependent vasodilatation pattern.

Conclusion

The study does not support the hypothesis of a different cardiovascular effect of biomass or tobacco smoke exposure in patients with chronic obstructive pulmonary disease. Cardiovascular comorbidity should be assessed in patients with biomass-associated disease, similarly to subjects with tobacco-related disease.

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Acknowledgements

This research was supported by Fundación Ramón Domínguez [Grant Number: O-023].

Author information

Authors and Affiliations

  1. Servicio de Neumología, Hospital Universitario Lucus Augusti, Unidad Administrativa 4-A, c/Dr Ulises Romero no. 1, 27002, Lugo, Spain

    Rafael Golpe, Pilar Sanjuán-López, Irene Martín-Robles & Luis Pérez-de-Llano

  2. Servicio de Cardiología, Hospital Universitario Lucus Augusti, Lugo, Spain

    Carlos González-Juanatey

  3. Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen del Rocío, Seville, Spain

    José L. López-Campos

  4. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain

    José L. López-Campos

Authors
  1. Rafael Golpe
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  2. Pilar Sanjuán-López
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  3. Irene Martín-Robles
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  4. Carlos González-Juanatey
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  5. Luis Pérez-de-Llano
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  6. José L. López-Campos
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Contributions

RG: conception and design, obtained funding, recruitment of patients, data analysis and interpretation, drafting the manuscript, had full access to all of the data in the study, and takes responsibility for the integrity of the data. PS-L: recruitment of patients, acquisition of data, and critical revision of the manuscript for important intellectual content. IM-R: recruitment of patients, acquisition of data, and critical revision of the manuscript for important intellectual content. CG-J: conception and design, acquisition of data, drafting the manuscript, and critical revision of the manuscript for important intellectual content. LP-d-L: conception and design, obtained funding, study supervision, and drafting the manuscript. JLL-C: provided material support and critical revision of the manuscript for important intellectual content.

Corresponding author

Correspondence to Rafael Golpe.

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Conflict of interest

The authors report no conflict of interest in this work.

Ethical Approval

The study was performed in accordance with the 1964 Declaration of Helsinki and its later amendments and it was approved by our ethical committee (Comité Autonómico de Ética de la Investigación de Galicia, Registry Number: 2012/003).

Informed Consent

Informed written consent was obtained from all the subjects, prior to the inclusion in the study.

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Golpe, R., Sanjuán-López, P., Martín-Robles, I. et al. Cardiovascular Studies in Patients with Chronic Obstructive Pulmonary Disease Due to Biomass Smoke or Tobacco. Lung 196, 195–200 (2018). https://doi.org/10.1007/s00408-018-0095-9

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  • DOI: https://doi.org/10.1007/s00408-018-0095-9

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