Abstract
Background
Few studies have looked at lung cancer in prisoners, despite this population is possibly at increased risk of malignancy. In a previous study, we found an early onset of lung cancer in prisoners. Thus, the present CARCAN study was aimed at assessing the epidemiological characteristics, management, prognosis, and incidence of lung cancer in prisoners compared to a sample of non-prisoner patients.
Method
We performed a multi-center observational case–control study. Cases were prisoners diagnosed with lung cancer from 2005 to 2013. Controls were non-prisoner lung cancer patients selected from hospital databases and randomly matched to cases (targeted case–control ratio: 1:3). Incidence rates in both groups were calculated using national statistics.
Results
Seventy-two cases and 170 controls met inclusion criteria. Cases were mainly men (99%). Mean age at diagnosis was 52.9 (± 11.0) in cases and 64.3 (± 10.1) in controls (p < 0.0001). More case patients were current smokers compared to control patients (83% vs 53%; p < 0.0001). We found no significant differences between the two groups as concerns histologic types, TNM stages at diagnosis, initially-employed treatments, times to management or survival. Incidence rates (2008–2012) in male prisoners were higher than those in the general population in all concerned age groups.
Conclusion
There is a shift of lung cancer toward young people in prisons. However, the presentation, management, and prognosis of lung cancer are similar between prisoners and non-prisoners. These finding could justify a specific screening policy for the incarcerated populations.
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Acknowledgements
Authors thank M. Kevin Erwin for expert English rewording.
Funding
This study was supported by Grants from AGIRADOM and Chugai Pharma France. The sponsors had no role in the study.
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Dr. MOLINIER reports grants, personal fees and non-financial support from SANOFI, personal fees and non-financial support from JANSSEN CILAG, personal fees from ABBVIE, personal fees from NESTLE, outside the submitted work. Dr. COURAUD reports grants from Chugai Pharma France, grants from AGIRADOM, during the conduct of the study; grants and non-financial support from BMS, grants, personal fees and non-financial support from Astra Zeneca, grants, personal fees and non-financial support from Pfizer, grants, personal fees, non-financial support and other from Roche, grants, personal fees, non-financial support and other from Chugai, personal fees and other from MSD, grants, personal fees, non-financial support and other from Boehringer Ingelheim, grants and non-financial support from Sysmex Innostics, grants, personal fees and non-financial support from Lilly, grants from Novartis, grants from Merck, grants and personal fees from Laidet Medical, grants and non-financial support from Amgen, outside the submitted work. Dr. GREILLIER reports grants, personal fees and non-financial support from ROCHE, personal fees and non-financial support from LILLY, grants and personal fees from NOVARTIS, personal fees and non-financial support from PFIZER, personal fees and non-financial support from BRISTOL-MYERS SQUIBB, personal fees and non-financial support from BOEHRINGER INGELHEIM, personal fees and non-financial support from ASTRA-ZENECA, outside the submitted work. Dr. RENAULT reports grants from Chugai Pharma France, grants from AGIRADOM, during the conduct of the study; non-financial support from Grünenthal, outside the submitted work. Other authors have nothing to disclose.
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Renault, L., Perrot, E., Pradat, E. et al. Concerns About Lung Cancer Among Prisoners. Lung 196, 115–124 (2018). https://doi.org/10.1007/s00408-017-0066-6
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DOI: https://doi.org/10.1007/s00408-017-0066-6