Abstract
Purpose
Older patients with lung cancer are a heterogeneous population making treatment decisions complex. This study aims to evaluate the value of geriatric assessment (GA) as well as the evolution of functional status (FS) in older patients with lung cancer, and to identify predictors associated with functional decline and overall survival (OS).
Methods
At baseline, GA was performed in patients ≥70 years with newly diagnosed lung cancer. FS measured by activities of daily living (ADL) and instrumental activities of daily living (IADL) was reassessed at follow-up to define functional decline and OS was collected. Predictors for functional decline and OS were determined.
Results
Two hundred and forty-five patients were included in this study. At baseline, GA deficiencies were present in all domains and ADL and IADL were impaired in 51 and 63% of patients, respectively. At follow-up, functional decline in ADL was observed in 23% and in IADL in 45% of patients. In multivariable analysis, radiotherapy was predictive for ADL decline. No other predictors for ADL or IADL decline were identified. Stage and baseline performance status were predictive for OS.
Conclusions
Older patients with lung cancer present with multiple deficiencies covering all geriatric domains. During treatment, functional decline is observed in almost half of the patients. None of the specific domains of the GA were predictive for functional decline or survival, probably because of the high impact of the aggressiveness of this tumor type leading to a poor prognosis.
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References
SEER cancer statistics factsheets: lung and bronchus cancer. National Cancer Institute. Bethesda. http://seer.cancer.gov/statfacts/html/lungb.html
Blanco JAG, Toste IS, Alvarez RF, Cuandrado GR, Gonzalez AM, Maltin IJ et al (2008) Age, comorbidity, treatment decision and prognosis in lung cancer. Age Ageing 37:715–718
Peake MD, Thompson S, Lowe D, Pearson MG (2003) Ageism in the management of lung cancer. Age Ageing 32:171–177
Janssen-Heijnen MLG, Smulders S, Lemmens VEPP, Smeenk FWJM, Van Geffen HJAA, Coebergh JWW et al (2004) Effect of comorbidity on the treatment and prognosis of elderly patients with non-small cell lung cancer. Thorax 59:602–607
Lewis JH, Kilgore ML, Goldman DP et al (2003) Participation of patients 65 years of age or older in cancer clinical trials. J Clin Oncol 21:1383–1389
Wedding U, Kodding D, Pientka L et al (2007) Physicians’ judgement and comprehensive geriatric assessment (CGA) select different patients as fit for chemotherapy. Crit Rev Oncol Hematol 64:1–9
Solomon D, Sue Brown A, Brummel-Smith K et al (2003) National Institutes of Health Consensus Development Conference Statement: geriatric assessment methods for clinical decision-making. J Am Geriatr Soc 51(10):1490–1494
Kenis C, Bron D, Libert Y, Decoster L, Van Puyvelde K, Scaillet P et al (2013) Relevance of a systematic geriatric screening and assessment in older patients with cancer: results of a prospective multicentric study. Ann Oncol 24(5):1306–1312
Kenis C, Decoster L, Van Puyvelde K, De Grève J, Conings G, Milisen K et al (2014) Performance of two geriatric screening tools in older patients with cancer. J Clin Oncol 32(1):19–26
Decoster L, Van Puyvelde K, Mohile S, Weddong U, Basso U, Colloca G et al (2015) Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations. Ann Oncol 26(2):288–300
Wildiers H, Heeren P, Puts M et al (2014) International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer. J Clin Oncol 32:2595–2603
Kenis C, Flamaing J, Debruyne PR et al (2015) A nationwide implementation of a multidisciplinary geriatric assessment and intervention program in Belgian older patients with cancer. J Geriatr Oncol 6(suppl 1):S13
Pottel L, Boterberg T, Pottel H et al (2012) Determination of an adequate screening tool for the identification of vulnerable elderly head and neck cancer patients treated with radio(chemo)therapy. J Geriatr Oncol 3:24–32
Decoster L, Vanacker L, Kenis C, Prenen H, Van Cutsem E, Van Der Auwera J et al (2016) Relevance of geriatric assessment in older patients with colorectal cancer. Clin Colorectal Cancer. doi:10.1016/j.clcc.2016.07.010
Schulkens KJ, Souwer ETD, Hamaker ME et al (2017) The effect of geriatric assessment on treatment decisions for patients with lung cancer. Lung. doi:10.1007/s00408-017-9983-7
Hurria A, Togawa K, Mohile SG, Owusu C, Klepin HD, Gross CP et al (2011) Predicting chemotherapy toxicity in older adults with cancer: a prospective multicenter study. J Clin Oncol 29:3457–3465
Hurria A, Mohile S, Gajra A, Klepin H, Muss H, Chapman A et al (2016) Validation of a prediction tool for chemotherapy toxicity in older adults with cancer. J Clin Oncol 34:2366–2371
Extermann M, Boler I, Reich RR, Lyman GH, Brown RH, DeFelice J et al (2012) Predicting the risk of chemotherapy toxicity in older patients: the chemotherapy risk assessment scale for high-age patients (CRASH) score. Cancer 118:3377–3386
Nie X, Liu D, Liu Q, Bai C (2013) Predicting chemotherapy toxicity in older adults with lung cancer. J Geriatr Oncol 4:334–339
Girre V, Falcou MC, Gisselbrecht M, Gridel G, Mosseri V, Bouleuc C et al (2008) Does a geriatric oncology consultation modify the cancer treatment plan for elderly patients? J Gerontol Ser A 7:724–730
Caillet P, Canoui-Poitrine F, Vouriot J, Berle M, Reinald N, Kryciak S et al (2011) Comprehensive geriatric assessment in the decision-making process in elderly patients with cancer: ELCAPA study. J Clin Oncol 29:3636–3642
Corre R, Greillier L, Le Caër H, Audigier-Valette C, Baize N, Bérard H et al (2016) Use of a comprehensive geriatric assessment for the management of elderly patients with advanced non-small-cell lung cancer: the phase III randomized ESOGIA-GFPC-GECP 08-02 study. J Clin Oncol 34:1476–1483
Chouliara Z, Miller M, Stott D et al (2004) Older people with cancer: perceptions and feelings about information, decision-making and treatment—a pilot study. Eur J Oncol Nurs 8:257–261
Puts MTE, Monette J, Girre V, Wolfson C, Monette M, Batist G et al (2011) Changes in functional status in older newly-diagnosed cancer patients during cancer treatment: a six-month follow-up period. Results of a prospective pilot study. J Geriatr Oncol 2:112–120
Ronning B, Wyller TB, Jordhoy MS, Nesbakken A, Bakka A, Seljeflot I et al (2014) Frailty indicators and functional status in older patients after colorectal cancer surgery. J Geriatr Oncol 5:26–32
Kenis C, Decoster L, Bastin J, Bode H, Van Puyvelde K, De Grève J et al (2017) Functional decline in older patients with cancer receiving chemotherapy: a multicenter prospective study. J Geriatr Oncol 8:196–205
Read WL, Tierney RM, Page IVC, Costas I, Govindar R, Spitznagel ELJ et al (2004) Differential prognostic impact of comorbidity. J Clin Oncol 22:3099–3130
Maione P, Perrone F, Gallo C, Manzione L, Piantedosi FV, Barbera S et al (2005) Pretreatment quality of life and functional status assessment significantly predict survival of elderly patients with advanced NSCLC receiving chemotherapy: a prognostic analysis of the multicenter Italian lung cancer in the elderly study. J Clin Oncol 23:6865–6872
Pallis AG, Gridelli C, Wedding U, Faivre-Finn C, Veronesi G, Jaklitsch M et al (2014) Management of elderly patients with NSCLC updated expert’s opinion paper: EORTC elderly task force, lung cancer group and international society for geriatric oncology. Ann Oncol 25:1270–1283
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This research was funded by the National Cancer Plan, action 24 of the Belgian Government.
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Decoster, L., Kenis, C., Schallier, D. et al. Geriatric Assessment and Functional Decline in Older Patients with Lung Cancer. Lung 195, 619–626 (2017). https://doi.org/10.1007/s00408-017-0025-2
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DOI: https://doi.org/10.1007/s00408-017-0025-2