Abstract
Purpose
Genetic susceptibility for tuberculosis in human has been previously demonstrated. Polymorphisms in genes involved in immune responses may alter the susceptibility of individuals to tuberculosis. Polymorphisms of beta-2 adrenergic receptor (ADRB2) gene can be possibly an important risk factor in tuberculosis. In this study, the association between rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene and tuberculosis was evaluated.
Methods
Genotype distributions of the rs1042713 (Arg16Gly +46A>G) and rs1042714 (Gln27Glu +79C>G) polymorphisms in ADRB2 gene in 106 patients with pulmonary tuberculosis and 88 healthy subjects were studied by PCR–RFLP method in an Iranian population.
Results
The frequency of rs1042713*G and rs1042714*G alleles in ADRB2 gene in tuberculosis patients was significantly different from healthy controls [odds ratio (OR) 0.176, 95% confidence interval (CI) 0.065–0.48, P value <0.001 and OR 0.45, 95% CI 0.247–0.825, P value = 0.009, respectively]. There were no significant differences in haplotype analysis between the patients and control subjects.
Conclusion
The association was reported between rs1042713 and rs1042714 polymorphisms in ADRB2 gene and tuberculosis for the first time. rs1042713*G and rs1042714*G polymorphisms in ADRB2 gene makes people more susceptible to develop the disease.
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Acknowledgements
This work was supported by the Deputy of Research and Technology of Urmia University of Medical Sciences, Urmia, Iran (Grant No. 1393-04-32-1322). The authors would like to thank Infectious & Tropical Disease Research Center and Tuberculosis and Lung Diseases Research Center in Tabriz University of Medical Sciences. The authors also thank all the tuberculosis patients and their families who helped us to complete the required data.
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The study was approved by the Ethics Committee of Urmia University of Medical Sciences, Urmia, Iran, and all subjects signed informed consents. “All the procedures performed in this study involving human participants were in accordance with ethical standards of the ethics committee of Urmia University of Medical Sciences and with the 1964 Helsinki declaration and it’s later amendments or comparable ethical standards.”
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Informed consent was obtained from all individual participants included in this study.
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Azar, A.F., Jazani, N.H., Bazmani, A. et al. Polymorphisms in Beta-2 Adrenergic Receptor Gene and Association with Tuberculosis. Lung 195, 147–153 (2017). https://doi.org/10.1007/s00408-016-9968-y
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DOI: https://doi.org/10.1007/s00408-016-9968-y