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A Paradox: α-Klotho Levels and Smoking Intensity

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Abstract

Reports regarding smoking differences in α-klotho expression have provided conflicting results. In the current study we focused on the influence of smoking intensity to serum levels of the aging molecule α-klotho in healthy smokers. 40 middle aged healthy smokers without airway obstruction or restriction were selected for the analysis. Serum levels of soluble α-klotho were significantly higher in heavy smokers (P < 0.001). These results are in agreement with the possibility that α-klotho acts as anti-inflammatory molecule and strengthen the hypothesis that an increase of serum levels of α-klotho might be a compensatory response to smoking stress in healthy population.

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Fig. 1

Note Subjects were classified into two groups according to PYS (<20; ≥20)

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Funding

This study was supported by a grant of NEUMOMADRID (2015).

Author information

Authors and Affiliations

  1. Department of Biomedical Sciences, Universidad Europea, 28670, Villaviciosa de Odón, Madrid, Spain

    Zoraida Verde & Luis Reinoso-Barbero

  2. Department of Neumology, Hospital Gregorio Marañón, Madrid, Spain

    Jose M. Rodríguez González-Moro

  3. Cátedra Complutense Diagnostic and Innovation, Universidad Complutense, Madrid, Spain

    Luis M. Chicharro

  4. Occupational Medicine, Grupo Banco Popular, Madrid, Spain

    Luis Reinoso-Barbero

  5. Department of Toxicology and Health Sanitary, Universidad Complutense, Madrid, Spain

    Fernando Bandrés

  6. School of Doctoral Studies & Research, Universidad Europea, Madrid, Spain

    Félix Gómez-Gallego & Catalina Santiago

Authors
  1. Zoraida Verde
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  2. Jose M. Rodríguez González-Moro
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  3. Luis M. Chicharro
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  4. Luis Reinoso-Barbero
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  5. Fernando Bandrés
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  6. Félix Gómez-Gallego
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  7. Catalina Santiago
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Corresponding author

Correspondence to Zoraida Verde.

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Ethical Approval

Approval was obtained from the local Ethics Committee (Hospital Gregorio Marañón, Madrid, Spain) and all patients provided written informed consent in accordance with the principles expressed in Helsinki Declaration.

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Verde, Z., González-Moro, J.M.R., Chicharro, L.M. et al. A Paradox: α-Klotho Levels and Smoking Intensity. Lung 195, 53–57 (2017). https://doi.org/10.1007/s00408-016-9944-6

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  • DOI: https://doi.org/10.1007/s00408-016-9944-6

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