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Primary Sarcomatoid Carcinoma of the Lung: Radiometabolic (18F-FDG PET/CT) Findings and Correlation with Clinico-Pathological and Survival Results

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Abstract

Introduction

Pulmonary sarcomatoid carcinoma (PSC) is a very rare and uninvestigated subtype of non-small cell lung cancer (NSCLC).

Methods

The aims of this study were to define the radiometabolic features (by 18F-FDG PET/CT) in a bi-centric cohort of 49 PSC patients and to explore their relation with clinico-pathological characteristics and long-term survival results after surgical treatment.

Results

There were 40 males and 9 females aged 65.2 ± 10.47 years. Overall long-term survival was 26.7 % at 5 years. Mean and median values of SUVmax were 15.21 and 15, respectively (SD ±5.5). Performing an age-, gender- and staging-matched analysis comparing PSC Stage-I only with a cohort of Stage-I NSCLC (n = 93), we observed significantly higher SUVmax values in PSC group (15.11 vs 7.66, p = 0.001).

Conclusions

No differences in terms of SUVmax were found with regard to tumour dimensions, histology (pure vs mixed, pleomorphic vs others), pathological stage and pattern of recurrence. P-stage, surgical radicality, vascular/lymphatic invasion but not SUVmax affected long-term survival in PSC.

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Authors and Affiliations

  1. Unit of Thoracic Surgery, Arcispedale Santa Maria Nuova-IRCCS, via Risorgimento 80, 42100, Reggio Emilia, Italy

    Cristian Rapicetta, Filippo Lococo, Tommaso Ricchetti & Massimiliano Paci

  2. Unit of Thoracic Surgery, University of Modena and Reggio Emilia, Modena, Italy

    Alessandro Stefani

  3. Unit of Pathology, University of Modena and Reggio Emilia, Modena, Italy

    Giulio Rossi

  4. Department of Nuclear Medicine, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy

    Angelina Filice

  5. Department of Nuclear Medicine, University of Modena and Reggio Emilia, Modena, Italy

    Antonella Franceschetto

  6. Department of Nuclear Medicine and PET/CT Center, Oncology Institute of Southern Switzerland, Bellinzona, Switzerland

    Giorgio Treglia

Authors
  1. Cristian Rapicetta
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  2. Filippo Lococo
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  3. Alessandro Stefani
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  4. Giulio Rossi
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  5. Tommaso Ricchetti
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  6. Angelina Filice
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  7. Antonella Franceschetto
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  8. Giorgio Treglia
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  9. Massimiliano Paci
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Corresponding author

Correspondence to Filippo Lococo.

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Rapicetta, C., Lococo, F., Stefani, A. et al. Primary Sarcomatoid Carcinoma of the Lung: Radiometabolic (18F-FDG PET/CT) Findings and Correlation with Clinico-Pathological and Survival Results. Lung 194, 653–657 (2016). https://doi.org/10.1007/s00408-016-9904-1

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  • DOI: https://doi.org/10.1007/s00408-016-9904-1

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