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Severe Soft Tissue Infections of the Head and Neck: A Primer for Critical Care Physicians

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Abstract

Patients with severe infections of the potential spaces of the head and neck are commonly managed in the ICU. These infections may present with devastating complications such as airway obstruction, jugular septic thrombophlebitis, lung abscess, upper airway abscess rupture with asphyxiation, mediastinitis, pericarditis, and septic shock. A thorough understanding of the anatomy and microbiology of these infections is essential for proper management of these patients. Retropharyngeal, danger, prevertebral, lateral pharyngeal, and submandibular space infections and their site-specific clinical manifestations, complications, and therapeutic interventions are discussed.

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References

  1. Vieira F, Allen SM, Stocks RM, Thompson JW (2008) Deep neck infection. Otolaryngol Clin North Am 41(3):459–483

    Article  PubMed  Google Scholar 

  2. Agarwal AK, Sethi A, Sethi D, Mrig S, Chopra S (2007) Role of socioeconomic factors in deep neck abscess: a prospective study of 120 patients. Br J Oral Maxillofac Surg 45(7):553–555. doi:10.1016/j.bjoms.2007.01.001

    Article  PubMed  CAS  Google Scholar 

  3. Larawin V, Naipao J, Dubey SP (2006) Head and neck space infections. Otolaryngol Head Neck Surg 135(6):889–893. doi:10.1016/j.otohns.2006.07.007

    Article  PubMed  Google Scholar 

  4. Brook I (2004) Microbiology and management of peritonsillar, retropharyngeal, and parapharyngeal abscesses. J Oral Maxillofac Surg 62(12):1545–1550. doi:10.1016/j.joms.2003.12.043

    Article  PubMed  Google Scholar 

  5. Har-El G, Aroesty JH, Shaha A, Lucente FE (1994) Changing trends in deep neck abscess. A retrospective study of 110 patients. Oral Surg Oral Med Oral Pathol 77(5):446–450. doi:10.1016/0030-4220(94)90221-6

    Article  PubMed  CAS  Google Scholar 

  6. Huang TT, Tseng FY, Yeh TH, Hsu CJ, Chen YS (2006) Factors affecting the bacteriology of deep neck infection: a retrospective study of 128 patients. Acta Otolaryngol 126(4):396–401. doi:10.1080/00016480500395195

    Article  PubMed  Google Scholar 

  7. Brook I, Hunter V, Walker RI (1984) Synergistic effect of bacteroides, clostridium, fusobacterium, anaerobic cocci, and aerobic bacteria on mortality and induction of subcutaneous abscesses in mice. J Infect Dis 149(6):924–928

    PubMed  CAS  Google Scholar 

  8. Coulthard M, Isaacs D (1991) Retropharyngeal abscess. Arch Dis Child 66(10):1227–1230. doi:10.1136/adc.66.10.1227

    Article  PubMed  CAS  Google Scholar 

  9. Brook I (2004) Beta-lactamase-producing bacteria in mixed infections. Clin Microbiol Infect 10(9):777–784. doi:10.1111/j.1198-743X.2004.00962.x

    Article  PubMed  CAS  Google Scholar 

  10. Lin HT, Tsai CS, Chen YL, Liang JG (2006) Influence of diabetes mellitus on deep neck infection. J Laryngol Otol 120(8):650–654. doi:10.1017/S0022215106001149

    Article  PubMed  Google Scholar 

  11. Wang LF, Kuo WR, Tsai SM, Huang KJ (2003) Characterizations of life-threatening deep cervical space infections: a review of one hundred ninety-six cases. Am J Otolaryngol 24(2):111–117. doi:10.1053/ajot.2003.31

    Article  PubMed  CAS  Google Scholar 

  12. Rega AJ, Aziz SR, Ziccardi VB (2006) Microbiology and antibiotic sensitivities of head and neck space infections of odontogenic origin. J Oral Maxillofac Surg 64(9):1377–1380. doi:10.1016/j.joms.2006.05.023

    Article  PubMed  Google Scholar 

  13. Flynn TR, Shanti RM, Levi MH, Adamo AK, Kraut RA, Trieger N (2006) Severe odontogenic infections, part 1: prospective report. J Oral Maxillofac Surg 64(7):1093–1103. doi:10.1016/j.joms.2006.03.015

    Article  PubMed  Google Scholar 

  14. Flynn TR, Shanti RM, Hayes C (2006) Severe odontogenic infections, part 2: prospective outcomes study. J Oral Maxillofac Surg 64(7):1104–1113. doi:10.1016/j.joms.2006.03.031

    Article  PubMed  Google Scholar 

  15. Sato K, Izumi T, Toshima M, Nagai T, Muroi K, Komatsu N, Ozawa K (2005) Retropharyngeal abscess due to methicillin-resistant Staphylococcus aureus in a case of acute myeloid leukemia. Intern Med 44(4):346–349. doi:10.2169/internalmedicine.44.346

    Article  PubMed  Google Scholar 

  16. Kobayashi KI, Haruta T, Kubota M, Nishio T (2002) A case of retropharyngeal abscess caused by penicillin-resistant Streptococcus pneumoniae. J Infect 44(4):267–269. doi:10.1053/jinf.2002.0991

    Article  PubMed  Google Scholar 

  17. Frazee BW, Lynn J, Charlebois ED, Lambert L, Lowery D, Perdreau-Remington F (2005) High prevalence of methicillin-resistant Staphylococcus aureus in emergency department skin and soft tissue infections. Ann Emerg Med 45(3):311–320. doi:10.1016/j.annemergmed.2004.10.011

    Article  PubMed  Google Scholar 

  18. Zetola N, Francis JS, Nuermberger EL, Bishai WR (2005) Community-acquired methicillin-resistant Staphylococcus aureus: an emerging threat. Lancet Infect Dis 5(5):275–286. doi:10.1016/S1473-3099(05)70112-2

    Article  PubMed  Google Scholar 

  19. Wertheim HF, Melles DC, Vos MC, van Leeuwen W, van Belkum A, Verbrugh HA, Nouwen JL (2005) The role of nasal carriage in Staphylococcus aureus infections. Lancet Infect Dis 5(12):751–762. doi:10.1016/S1473-3099(05)70295-4

    Article  PubMed  Google Scholar 

  20. Fleisch AF, Nolan S, Gerber J, Coffin SE (2007) Methicillin-resistant Staphylococcus aureus as a cause of extensive retropharyngeal abscess in two infants. Pediatr Infect Dis J 26(12):1161–1163. doi:10.1097/INF.0b013e3181461b3a

    Article  PubMed  Google Scholar 

  21. Thomason TS, Brenski A, McClay J, Ehmer D (2007) The rising incidence of methicillin-resistant Staphylococcus aureus in pediatric neck abscesses. Otolaryngol Head Neck Surg 137(3):459–464. doi:10.1016/j.otohns.2007.05.010

    Article  PubMed  Google Scholar 

  22. Kuriyama T, Karasawa T, Nakagawa K, Nakamura S, Yamamoto E (2002) Antimicrobial susceptibility of major pathogens of orofacial odontogenic infections to 11 beta-lactam antibiotics. Oral Microbiol Immunol 17(5):285–289. doi:10.1034/j.1399-302X.2002.170504.x

    Article  PubMed  CAS  Google Scholar 

  23. Chen MK, Wen YS, Chang CC, Huang MT, Hsiao HC (1998) Predisposing factors of life-threatening deep neck infection: logistic regression analysis of 214 cases. J Otolaryngol 27(3):141–144

    PubMed  CAS  Google Scholar 

  24. Boscolo-Rizzo P, Da Mosto MC (2009) Submandibular space infection: a potentially lethal infection. Int J Infect Dis 13(3):322–333

    Article  Google Scholar 

  25. Ovassapian A, Tuncbilek M, Weitzel EK, Joshi CW (2005) Airway management in adult patients with deep neck infections: a case series and review of the literature. Anesth Analg 100(2):585–589. doi:10.1213/01.ANE.0000141526.32741.CF

    Article  PubMed  Google Scholar 

  26. Karkos PD, Leong SC, Beer H, Apostolidou MT, Panarese A (2007) Challenging airways in deep neck space infections. Am J Otolaryngol 28(6):415–418. doi:10.1016/j.amjoto.2006.10.012

    Article  PubMed  Google Scholar 

  27. Yuen HW, Loy AH, Johari S (2007) Urgent awake tracheotomy for impending airway obstruction. Otolaryngol Head Neck Surg 136(5):838–842. doi:10.1016/j.otohns.2006.12.012

    Article  PubMed  Google Scholar 

  28. Potter JK, Herford AS, Ellis E 3rd (2002) Tracheotomy versus endotracheal intubation for airway management in deep neck space infections. J Oral Maxillofac Surg 60(4):349–354 discussion 354-355

    Article  PubMed  Google Scholar 

  29. Meyers BR, Lawson W, Hirschman SZ (1972) Ludwig’s angina. case report, with review of bacteriology and current therapy. Am J Med 53(2):257–260. doi:10.1016/0002-9343(72)90134-9

    Article  PubMed  CAS  Google Scholar 

  30. Fischmann GE, Graham BS (1985) Ludwig’s angina resulting from the infection of an oral malignancy. J Oral Maxillofac Surg 43(10):795–796. doi:10.1016/0278-2391(85)90337-4

    Article  PubMed  CAS  Google Scholar 

  31. Tsuji T, Shimono M, Yamane G, Noma H (1984) Ludwig’s angina as a complication of ameloblastoma of the mandible. J Oral Maxillofac Surg 42(12):815–819. doi:10.1016/0278-2391(84)90352-5

    Article  PubMed  CAS  Google Scholar 

  32. Levitt GW (1970) Cervical fascia and deep neck infections. Laryngoscope 80(3):409–435

    PubMed  CAS  Google Scholar 

  33. Rothwell BR (1985) Odontogenic infections. Emerg Med Clin North Am 3(1):161–178

    PubMed  CAS  Google Scholar 

  34. Megran DW, Scheifele DW, Chow AW (1984) Odontogenic infections. Pediatr Infect Dis 3(3):257–265

    PubMed  CAS  Google Scholar 

  35. Reynolds SC, Chow AW (2007) Life-threatening infections of the peripharyngeal and deep fascial spaces of the head and neck. Infect Dis Clin North Am 21(2):557–576. doi:10.1016/j.idc.2007.03.002

    Article  PubMed  Google Scholar 

  36. Scully RE, Galdabini JJ, McNeely BU (1975) Case records of the Massachusetts General Hospital: weekly clinicopathological exercises. case 33–1975. N Engl J Med 293(8):394–399

    Article  PubMed  CAS  Google Scholar 

  37. Blum DJ, McCaffrey TV (1983) Septic necrosis of the internal carotid artery: a complication of peritonsillar abscess. Otolaryngol Head Neck Surg 91(2):114–118

    PubMed  CAS  Google Scholar 

  38. Wills PI, Vernon RP Jr (1981) Complications of space infections of the head and neck. Laryngoscope 91(7):1129–1136. doi:10.1288/00005537-198107000-00010

    Article  PubMed  CAS  Google Scholar 

  39. Ramsey PG, Weymuller EA (1985) Complications of bacterial infection of the ears, paranasal sinuses, and oropharynx in adults. Emerg Med Clin North Am 3(1):143–160

    PubMed  CAS  Google Scholar 

  40. Knouse MC, Madeira RG, Celani VJ (2002) Pseudomonas aeruginosa causing a right carotid artery mycotic aneurysm after a dental extraction procedure. Mayo Clin Proc 77(10):1125–1130. doi:10.4065/77.10.1125

    Article  PubMed  Google Scholar 

  41. Sichel JY, Dano I, Hocwald E, Biron A, Eliashar R (2002) Nonsurgical management of parapharyngeal space infections: a prospective study. Laryngoscope 112(5):906–910. doi:10.1097/00005537-200205000-00023

    Article  PubMed  Google Scholar 

  42. Sakaguchi M, Sato S, Ishiyama T, Katsuno S, Taguchi K (1997) Characterization and management of deep neck infections. Int J Oral Maxillofac Surg 26(2):131–134. doi:10.1016/S0901-5027(05)80835-5

    Article  PubMed  CAS  Google Scholar 

  43. McClay JE, Murray AD, Booth T (2003) Intravenous antibiotic therapy for deep neck abscesses defined by computed tomography. Arch Otolaryngol Head Neck Surg 129(11):1207–1212. doi:10.1001/archotol.129.11.1207

    Article  PubMed  Google Scholar 

  44. Boscolo-Rizzo P, Marchiori C, Montolli F, Vaglia A, Da Mosto MC (2006) Deep neck infections: a constant challenge. ORL J Otorhinolaryngol Relat Spec 68(5):259–265. doi:10.1159/000093095

    PubMed  Google Scholar 

  45. Boscolo-Rizzo P, Marchiori C, Zanetti F, Vaglia A, Da Mosto MC (2006) Conservative management of deep neck abscesses in adults: the importance of CECT findings. Otolaryngol Head Neck Surg 135(6):894–899. doi:10.1016/j.otohns.2006.05.013

    Article  PubMed  Google Scholar 

  46. Brazier JS (2006) Human infections with Fusobacterium necrophorum. Anaerobe 12(4):165–172. doi:10.1016/j.anaerobe.2005.11.003

    Article  PubMed  Google Scholar 

  47. Chirinos JA, Lichtstein DM, Garcia J, Tamariz LJ (2002) The evolution of Lemierre syndrome: report of 2 cases and review of the literature. Medicine (Baltimore) 81(6):458–465. doi:10.1097/00005792-200211000-00006

    Article  Google Scholar 

  48. Dool H, Soetekouw R, van Zanten M, Grooters E (2005) Lemierre’s syndrome: three cases and a review. Eur Arch Otorhinolaryngol 262(8):651–654. doi:10.1007/s00405-004-0880-3

    Article  PubMed  Google Scholar 

  49. Sinave CP, Hardy GJ, Fardy PW (1989) The Lemierre syndrome: suppurative thrombophlebitis of the internal jugular vein secondary to oropharyngeal infection. Medicine (Baltimore) 68(2):85–94. doi:10.1097/00005792-198903000-00002

    CAS  Google Scholar 

  50. Endo S, Tsubochi H, Nakano T, Sohara Y (2008) Descending necrotizing mediastinitis secondary to retropharyngeal abscess without cervical spread. Gen Thorac Cardiovasc Surg 56(1):25–27. doi:10.1007/s11748-007-0182-y

    Article  PubMed  Google Scholar 

  51. Barratt GE, Koopmann CF Jr, Coulthard SW (1984) Retropharyngeal abscess—a ten-year experience. Laryngoscope 94(4):455–463. doi:10.1288/00005537-198404000-00003

    Article  PubMed  CAS  Google Scholar 

  52. Misthos P, Katsaragakis S, Kakaris S, Theodorou D, Skottis I (2007) Descending necrotizing anterior mediastinitis: analysis of survival and surgical treatment modalities. J Oral Maxillofac Surg 65(4):635–639. doi:10.1016/j.joms.2006.06.287

    Article  PubMed  Google Scholar 

  53. Takao M, Ido M, Hamaguchi K, Chikusa H, Namikawa S, Kusagawa M (1994) Descending necrotizing mediastinitis secondary to a retropharyngeal abscess. Eur Respir J 7(9):1716–1718. doi:10.1183/09031936.94.07091716

    Article  PubMed  CAS  Google Scholar 

  54. Sandner A, Borgermann J, Kosling S, Silber RE, Bloching MB (2007) Descending necrotizing mediastinitis: early detection and radical surgery are crucial. J Oral Maxillofac Surg 65(4):794–800. doi:10.1016/j.joms.2005.11.075

    Article  PubMed  Google Scholar 

  55. Chow AW (2005) Life-threatening infections of the head, neck and upper respiratory tract. In: Hall JB, Schmidt GA, Wood LD (eds) Principles of critical care, 3rd edn. McGraw-Hill, New York, pp 881–896

    Google Scholar 

  56. Plaza Mayor G, Martinez-San Millan J, Martinez-Vidal A (2001) Is conservative treatment of deep neck space infections appropriate? Head Neck 23(2):126–133. doi:10.1002/1097-0347(200102)23:2<126::AID-HED1007>3.0.CO;2-N

    Article  PubMed  CAS  Google Scholar 

  57. Ungkanont K, Yellon RF, Weissman JL, Casselbrant ML, Gonzalez-Valdepena H, Bluestone CD (1995) Head and neck space infections in infants and children. Otolaryngol Head Neck Surg 112(3):375–382. doi:10.1016/S0194-5998(95)70270-9

    Article  PubMed  CAS  Google Scholar 

  58. Courtney MJ, Mahadevan M, Miteff A (2007) Management of paediatric retropharyngeal infections: non-surgical versus surgical. ANZ J Surg 77(11):985–987. doi:10.1111/j.1445-2197.2007.04295.x

    Article  PubMed  Google Scholar 

  59. Adelson RT, Murray AD (2005) Minimally invasive transoral catheter-assisted drainage of a danger-space infection. Ear Nose Throat J 84(12):785–786

    PubMed  Google Scholar 

  60. Bulut M, Balci V, Akkose S, Armagan E (2004) Fatal descending necrotising mediastinitis. Emerg Med J 21(1):122–123. doi:10.1136/emj.2003.002865

    Article  PubMed  CAS  Google Scholar 

  61. Grewal S, Hocking G, Wildsmith JA (2006) Epidural abscesses. Br J Anaesth 96(3):292–302. doi:10.1093/bja/ael006

    Article  PubMed  CAS  Google Scholar 

  62. Pina MA, Modrego PJ, Uroz JJ, Cobeta JC, Lerin FJ, Baiges JJ (2001) Brucellar spinal epidural abscess of cervical location: report of four cases. Eur Neurol 45(4):249–253. doi:10.1159/000052137

    Article  PubMed  CAS  Google Scholar 

  63. Krishnan A, Patkar D, Patankar T, Shah J, Prasad S, Bunting T, Castillo M, Mukherji SK (2001) Craniovertebral junction tuberculosis: a review of 29 cases. J Comput Assist Tomogr 25(2):171–176. doi:10.1097/00004728-200103000-00003

    Article  PubMed  CAS  Google Scholar 

  64. Reihsaus E, Waldbaur H, Seeling W (2000) Spinal epidural abscess: a meta-analysis of 915 patients. Neurosurg Rev 23(4):175–204; discussion 205

    Article  PubMed  CAS  Google Scholar 

  65. Gordon RJ, Lowy FD (2005) Bacterial infections in drug users. N Engl J Med 353(18):1945–1954. doi:10.1056/NEJMra042823

    Article  PubMed  CAS  Google Scholar 

  66. Darouiche RO (2006) Spinal epidural abscess. N Engl J Med 355(19):2012–2020. doi:10.1056/NEJMra055111

    Article  PubMed  CAS  Google Scholar 

  67. Davis DP, Wold RM, Patel RJ, Tran AJ, Tokhi RN, Chan TC, Vilke GM (2004) The clinical presentation and impact of diagnostic delays on emergency department patients with spinal epidural abscess. J Emerg Med 26(3):285–291. doi:10.1016/j.jemermed.2003.11.013

    Article  PubMed  Google Scholar 

  68. Curry WT Jr, Hoh BL, Amin-Hanjani S, Eskandar EN (2005) Spinal epidural abscess: clinical presentation, management, and outcome. Surg Neurol 63(4):364–371 discussion 371

    Article  PubMed  Google Scholar 

  69. Muckley T, Schutz T, Kirschner M, Potulski M, Hofmann G, Buhren V (2003) Psoas abscess: the spine as a primary source of infection. Spine 28(6):E106–E113. doi:10.1097/00007632-200303150-00021

    Article  PubMed  Google Scholar 

  70. Hanigan WC, Asner NG, Elwood PW (1990) Magnetic resonance imaging and the nonoperative treatment of spinal epidural abscess. Surg Neurol 34(6):408–413. doi:10.1016/0090-3019(90)90245-K

    Article  PubMed  CAS  Google Scholar 

  71. Brook I (2007) Microbiology and principles of antimicrobial therapy for head and neck infections. Infect Dis Clin North Am 21(2):355–391 vi

    Article  PubMed  Google Scholar 

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Acknowledgment

Thanks to Dr. Peter Phillips, MD, and Dr. Tim Lau, PhD, for their thoughtful feedback and suggestions after reviewing the initial manuscript.

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Correspondence to Steven C. Reynolds.

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Reynolds, S.C., Chow, A.W. Severe Soft Tissue Infections of the Head and Neck: A Primer for Critical Care Physicians. Lung 187, 271–279 (2009). https://doi.org/10.1007/s00408-009-9153-7

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