, 186:293 | Cite as

Tracheobronchopathia Osteochondroplastica: Presentation of Ten Cases and Review of the Literature

  • Hamid Reza JabbardarjaniEmail author
  • Badiozaman Radpey
  • Shahram Kharabian
  • Mohammad Reza Masjedi


Tracheobronchopathia osteochondroplastica (TO) is a rare benign disease of the endobronchial system with nonspecific symptoms and different treatment approaches. We report on a group of patients with TO and discuss their presentation and their treatment modalities. Between 2000 and 2006, the medical records of patients with TO were studied at the Interventional Pulmonary Unit of the Tracheal Disease Research Center at Masih Daneshvary Hospital, a referral center for respiratory diseases in Tehran, Iran. We analyzed and studied patients’ demographics, symptom presentation, radiographic appearance, bronchoscopic findings, and their subsequent treatment. Of the 8760 patients who underwent flexible bronchoscopy (FOB) at our center over 6 years, 10 were diagnosed with TO; their median age was 51 years (range = 16–68 years) and 6 were men. Computerized tomography (CT) revealed mucosal irregularity and calcified nodules. Histopathologic examination of tissue biopsy through bronchoscopy was used for definitive diagnosis of TO. Bronchoscopy findings showed the endobronchial lesions to be firm and glossy. Cartilaginous nodules were present in central airways. Treatment included endobronchial Nd:YAG laser photoevaporation (LPE) (n = 10), coring of the lesions with the tip of the rigid bronchoscope (n = 4), and endobronchial stent placement (n = 1). Symptoms were considerably relieved in six cases but there was no significant improvement noted in three patients. One patient died after 6 years of treatment and follow-up. TO is a rare disease and the diagnosis should be suspected based on CT findings or bronchoscopic examination of the airways. Histopathologic examination is required for confirmation of diagnosis. Treatment is palliative and it includes LPE, coring through a rigid bronchoscope, and endobronchial stent placement.


Tracheobronchopathia osteochrondroplastica Rare lung disease Interventional pulmonology Fiberoptic bronchoscopy 



Fever and chills




Endobronchial nodule


Atrophic rhinitis


Endotracheal nodule




Main stem bronchus


Bronchiectatic changes



The authors thank Dr. Mehrdad Behnia for his help in editing this article.


  1. 1.
    Kanat F, Teke T, Ozer F (2005) Tracheobronchopathia osteochondroplastica associated with iron deficiency anemia. Indian J Chest Dis Allied Sci 47(1):47–51PubMedGoogle Scholar
  2. 2.
    Leske V, Lazor R, Coetmeur D, Crestani B, Chatté G, Cordier JF, Groupe d’Etudes et de Recherche sur les Maladies “Orphelines” Pulmonaires (GERM”O”P) (2001) Tracheobronchopathia osteochondroplastica: a study of 41 patients. Medicine (Baltimore) 80:378–390CrossRefGoogle Scholar
  3. 3.
    Bioque C, Feu N et al (2001) Tracheobronchopathia osteochondroplastica: clinical study and follow-up in nine cases. J Bronchol 8:78–83Google Scholar
  4. 4.
    Dutau H, Musani A (2004) Treatment of severe tracheobronchopathia osteochondroplastica. J Bronchol 11:182–185CrossRefGoogle Scholar
  5. 5.
    Wilks S (1857) Ossific deposits on larynx, trachea, and bronchi. Trans Pathol Soc Lond 8:88Google Scholar
  6. 6.
    Barthwal MS, Chatterji RS, Mehta A (2004) Tracheobronchopathia osteochondroplastica. Indian J Chest Dis Allied Sci 46:43–46PubMedGoogle Scholar
  7. 7.
    Dalgaard J (1947) Tracheobronchopathia chondro-osteoplastica: a case elucidating the problems concerning development and ossification of elastic cartilage. Acta Pathol Microbiol Scand 24:118–134Google Scholar
  8. 8.
    Moersch H, Broders A, Havens F (1937) Tracheopathia osteoplastica (osteoma of the trachea). Arch Otolaryngol 26:291–293Google Scholar
  9. 9.
    Secrest P, Kending T, Beland A (1964) Tracheobronchopathia osteochondroplastica. Am J Med 36:815–818PubMedCrossRefGoogle Scholar
  10. 10.
    Riker D, Campagna AC, Beamis JF (2007) Tracheobronchopathia presenting as hemoptysis associated with vascular endobronchial tumors. J Bronchol 14:212–214CrossRefGoogle Scholar
  11. 11.
    Park SS, Shin DH, Lee DH, Jeon SC, Lee JH, Lee JD (1995) Tracheopathia osteoplastica simulating asthmatic symptoms: diagnosis by bronchoscopy and computerized tomography. Respiration 62:43–45PubMedCrossRefGoogle Scholar
  12. 12.
    Vilkman S, Keistinen T (1995) Tracheobronchopathia osteochondroplastica: report of a young man with severe disease and retrospective review of 18 cases. Respiration 62:151–154PubMedGoogle Scholar
  13. 13.
    Lozar R, Cordier JF (2004) Tracheobronchopathia osteochondroplastica. Available at Accessed March 2, 2008
  14. 14.
    Smith DC, Pillai R, Gillbe CE (1987) Tracheobronchopathia osteochondroplastica: a cause of unexpected difficulty in tracheal intubation. Anaesthesia 42:536–538PubMedCrossRefGoogle Scholar
  15. 15.
    Coetmeur D, Bovyn G, Leroux P, Niel-Duriez M (1997) Tracheopathia osteochondroplastica presenting at the time of a difficult intubation. Respir Med 91:496–498PubMedCrossRefGoogle Scholar
  16. 16.
    Vega J, Fuertes A, Barrueco M et al (1994) Osteochondroplastic tracheobronchopathy, ostechondromas and recurrent sinusitis: a propos a case [in Spanish]. Ann Med Intern 11:35–37Google Scholar
  17. 17.
    Prakash U, McCullough A, Edell E, Nienhuis DM (1989) Tracheopathia osteoplastica: familial occurrence. Mayo Clin Proc 64:1091–1096PubMedGoogle Scholar
  18. 18.
    Nienhuis DM, Prakash U, Edell E (1990) Tracheobronchopathia osteochondroplastica. Ann Otol Rhinol Laryngol 99:689–694PubMedGoogle Scholar
  19. 19.
    Gleich LL, Rebeiz EE, Pankratov MM, Shapshay SM (1995) The holmium: YAG laser-assisted otolaryngologic procedures. Arch Otolaryngol Head Neck Surg 121:1162–1166PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2008

Authors and Affiliations

  • Hamid Reza Jabbardarjani
    • 1
    Email author
  • Badiozaman Radpey
    • 1
  • Shahram Kharabian
    • 1
  • Mohammad Reza Masjedi
    • 1
  1. 1.Tracheal Disease Research Center, NRITLD, Massih Daneshvari HospitalShahid Beheshti University, M.C.TehranIran

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