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RANTES Gene Promoter Polymorphisms Are Associated with Bronchial Hyperresponsiveness in Korean Children with Asthma

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Abstract

Regulated upon activation in normal T cells, expressed, and secreted (RANTES) protein is abundantly expressed during atopic asthma, suggesting that it is an important mediator of this disease. The aim of this study was to evaluate the possible role of RANTES promoter polymorphisms in children with asthma. We genotyped 271 children with atopic asthma, 55 children with nonatopic asthma, and 253 control children for allelic determinants at two polymorphic sites in the promoter region at positions −403G>A and −28C>G by restriction fragment length polymorphism methods. There was no significant difference in genotype and allele frequencies of the RANTES −403G>A and −28C>G polymorphisms when the atopic asthma, nonatopic asthma, and control groups were compared. However, atopic asthmatic patients who were homozygous GG for the RANTES −28C>G tended to have lower PC20 methacholine than those carrying the wild genotype. In addition, a significantly lower PC20 was demonstrated for the homozygous haplotype −403A/−28G in asthmatic children. The polymorphisms within the RANTES promoter may have a disease-modifying effect in Korean children with asthma.

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Acknowledgment

This study was supported by a faculty research grant (No. 6-2004-97) of Yonsei University College of Medicine for 2004.

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Authors and Affiliations

  1. Department of Pediatrics and Institute of Allergy, Yonsei University College of Medicine, Brain Korea 21 Project for Medical Sciences, Seoul, Korea

    Myung Hyun Sohn, Kyung-Won Kim, Hye Mi Jee & Kyu-Earn Kim

  2. Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea

    Seung-Hyun Kim & Hae-Sim Park

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  1. Myung Hyun Sohn
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  2. Seung-Hyun Kim
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  3. Kyung-Won Kim
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  4. Hye Mi Jee
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  6. Kyu-Earn Kim
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Correspondence to Kyu-Earn Kim.

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Myung Hyun Sohn and Seung-Hyun Kim contributed equally to this work.

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Sohn, M.H., Kim, SH., Kim, KW. et al. RANTES Gene Promoter Polymorphisms Are Associated with Bronchial Hyperresponsiveness in Korean Children with Asthma. Lung 186, 37–43 (2008). https://doi.org/10.1007/s00408-007-9049-3

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  • DOI: https://doi.org/10.1007/s00408-007-9049-3

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