Preclinical Assessment of Novel Therapeutics on the Cough Reflex: Cannabinoid Agonists as Potential Antitussives
- 121 Downloads
Cough, a reflex defense mechanism, is a common symptom of many airway inflammatory diseases. At present there are no satisfactory treatments for cough that have an acceptable side effect profile. Recent data have described the inhibitory effect of selective cannabinoid CB2 receptor agonists on sensory nerve activity in vitro and the cough reflex in a guinea pig model. CB2 receptor expression is limited in the central nervous system (CNS) and hence the development of selective agonists may provide a new therapeutic strategy for treatment of cough devoid of the CNS-mediated side effects that are normally associated with nonselective cannabinoid agonists.
KeywordsCannabinoids Cough Sensory nerves
- 2.Shroeder K, Fahey T (2002) Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ 324:1–6Google Scholar
- 15.Nasra J, Birrell MA, Poll C, Lewis CA, Belvisi MG (2007) Distinct patterns of response to tussive agents in a guinea-pig model of cough: effect of cigarette smoke exposure. Am J Respir Crit Care Med 41:A667Google Scholar
- 23.Clayton N, Marshall FH, Bountra C, O’Shaughnessy (2002) CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain. Pain 96:253–260Google Scholar