Skip to main content
SpringerLink
Log in

Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome

  • Published:
Lung Aims and scope Submit manuscript

Abstract

The aim of this study was to compare serum insulin-like growth factor (IGF-1) levels in patients with obstructive sleep apnea syndrome (OSAS) with those of nonapneic controls and to determine the risk factors of low IGF-1 levels in patients with OSAS. The study included 39 newly diagnosed moderate-to-severe OSAS patients and 36 nonapneic controls. Overnight polysomnography (PSG) was performed in all patients. The circulating levels of IGF-1 in the OSAS group were significantly lower than those of the control group (p < 0.05). There was a significant negative correlation between IGF-1 and logarithmic transformation (Ln) of the apnea-hypopnea index (AHI), duration of apnea-hypopnea, arousal index, average desaturation, and oxygen desaturation index (ODI). The result of stepwise regression analyses showed that OSAS (p = 0.001) was a risk factor for a low IGF-1 level, independent of age, gender, and body mass index (BMI). Our findings demonstrated that there was a significant negative correlation between IGF-1 and Ln AHI and that OSAS reduced the circulating levels of IGF-1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Hedner J, Grote L (1998) Cardiovascular consequences of obstructive sleep apnea. Eur Respir Mon 10:227–265

    Google Scholar 

  2. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, Kales A (2001) Prevalence of sleep disordered breathing in women; effects of gender. Am J Respir Crit Care Med 163:608–613

    PubMed  CAS  Google Scholar 

  3. Kyzer S, Charuzi I (1998) Obstructive sleep apnea in the obese. World J Surg 22:998–1001

    Article  PubMed  CAS  Google Scholar 

  4. Tapanainen P, Knip M (1992) Evaluation of growth hormone secretion and treatment. Ann Med 24:237–247

    PubMed  CAS  Google Scholar 

  5. Blum WF, Albertsson-Wikland K, Rosberg S, Ranke MB (1993) Serum levels of insulin like growth factor I (IGF-I) and IGF binding protein 3 reflects spontaneous growth hormone secretion. J Clin Endocrinol Metab 76:1610–1616

    Article  PubMed  CAS  Google Scholar 

  6. Engström BE, Karlsson FA, Wide L (1999) Gender differences in diurnal growth hormone and epinephrine values in young adults during ambulation. Clin Chem 45:1235–1239

    PubMed  Google Scholar 

  7. Minuto F, Barreca A, Del Monte P, Fortini P, Resentini M, Morabito F, Giordano G (1988) Spontaneous growth hormone and somatomedin-C/insulin like growth factor-I secretion in obese subjects during puberty. J Endocrinol Invest 11:489–495

    PubMed  CAS  Google Scholar 

  8. Bernstein D, Jasper JR, Rosenfeld RG, Hintz RL (1992) Decreased serum insulin like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease. J Clin Invest 89:1128–1132

    Article  PubMed  CAS  Google Scholar 

  9. Gronfier C, Luthringer R, Follenius M, Schaltenbrand N, Macher JP, Muzet A, Brandenberger G (1996) A quantitative evaluation of the relationships between growth hormone secretion and delta wave electroencephalographic activity during normal sleep and after enrichment delta waves. Sleep 19:817–824

    PubMed  CAS  Google Scholar 

  10. Bayes-Genis A, Conover CA, Schwartz RS (2000) The insulin like growth factor axis: A review of atherosclerosis and restenosis. Circ Res 86:125–130

    PubMed  CAS  Google Scholar 

  11. Rechtschaffen A, Kales A (eds) (1973) A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects, 3rd ed. Los Angeles: Brain Research Institute, pp 1–13

    Google Scholar 

  12. Xu Y, Li S, Huang X, Cong B (2002) Insulin like growth factor-I and cognitive function in patients with obstructive sleep apnea syndrome. Zhonghua Yi Xue Za Zhi 82:1388–1390

    PubMed  CAS  Google Scholar 

  13. McArdle N, Hillman D, Beilin L, Watts G (2007) Metabolic risk factors for vascular disease in obstructive sleep apnea: a matched controlled study. Am J Respir Crit Care Med 175:190–195

    Article  PubMed  CAS  Google Scholar 

  14. Gianotti L, Pivetti S, Lanfranco F, Tassone F, Navone F, Vittori E, Rossetto R, Gauna C, Destefanis S, Grottoli S, De Giorgi R, Gai V, Ghigo E, Maccario M (2002) Concomitant impairment of growth hormone secretion and peripheral sensitivity in obese patients with obstructive sleep apnea syndrome. J Clin Endocrinol Metab 87:5052–5057

    Article  PubMed  CAS  Google Scholar 

  15. Caufriez A, Golstein J, Lebrun P, Herchuelz A, Furlanetto R, Copinschi G (1984) Relations between immunoreactive somatomedin C, insulin and T3 patterns during fasting in obese subjects. Clin Endocrinol (Oxford) 20:65–70

    CAS  Google Scholar 

  16. Veldhuis JD, Iranmanesh A (1996) Physiologic regulation of the human growth hormone (GH)-insulin like growth factor type I (IGF-I) axis: predominant impact of age, obesity gonadal function, and sleep. Sleep 19(10 Suppl):S221–S224

    PubMed  CAS  Google Scholar 

  17. Maccario M, Ramunni J, Oleandri SE, Procopio M, Grottoli S, Rossetto R, Savio P, Aimaretti G, Camanni F, Ghigo E (1999) Relatioship between IGF-I and age, gender, body mass, fat distribution, metabolic and hormonal variables in obese patients. Int J Obes Metab Disord 23:612–618

    Article  CAS  Google Scholar 

  18. Gram IT, Norat T, Rinaldi S, Dossus L, Lukanova A, Tehard B, Clavel-Chapelon F, van Gils CH, van Noord PA, Peeters PH, Bueno-de-Mesquita HB, Nagel G, Linseisen J, Lahmann PH, Boeing H, Palli D, Sacerdote C, Panico S, Tumino R, Sieri S, Dorronsoro M, Quiros JR, Navarro CA, Barricarte A, Tormo MJ, Gonzalez CA, Overvad K, Paaske Johnsen S, Olsen A, Tjonneland A, Travis R, Allen N, Bingham S, Khaw KT, Stattin P, Trichopoulou A, Kalapothaki V, Psaltopoulou T, Casagrande C, Riboli E, Kaaks R (2006) Body mass index, waist circumference, and waist-hip ratio and serum levels of IGF-I and IGFBP-3 in European women. Int J Obes (Lond) 30:1623–1631

    Article  CAS  Google Scholar 

  19. Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, Walsleben JA, Finn L, Enright P, Samet JM, Sleep Heart Health Study Research Group (2002) Prediction of sleep disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 162:893–900

    Article  PubMed  Google Scholar 

  20. Issa FG, Sullivan CE (1986) The immediate effects of nasal continuous airway pressure treatment on sleep pattern in patients with obstructive sleep apnea syndrome. Electroencephalogr Clin Neurophysiol 63:10–17

    Article  PubMed  CAS  Google Scholar 

  21. Zhang Y-S, Du J-Z (2000) The response of growth hormone and prolactin of rats to hypoxia. Neurosci Lett 279:137–140

    Article  PubMed  CAS  Google Scholar 

  22. Han RN, Han VK, Buch S, Freeman BA, Post M, Tanswell AK (1998) Insulin-like growth factor binding proteins in air and 85% oxygen-exposed adult rat lung. Am J Physiol 274:L647–L656

    PubMed  CAS  Google Scholar 

  23. Polo O, Berthon-Jones M, Douglas NJ, Sullivan CE (1994) Management of obstructive sleep apnoea/hypopnoea syndrome. Lancet 344:656–660

    Article  PubMed  CAS  Google Scholar 

  24. Grunstein RR, Handelsman DJ, Lawrence SJ, Blackwell C, Caterson ID, Sullivan CE (1989) Neuroendocrine dysfunction in sleep apnea: reversal by continuous positive airway pressure therapy. J Clin Endocrinol Metab 68:352–358

    Article  PubMed  CAS  Google Scholar 

  25. Cooper BG, White JE, Ashworth LA, Alberti KG, Gibson GJ (1995) Hormonal and metabolic profiles in subjects with obstructive sleep apnea syndrome and acute effect of continuous positive airway pressure (CPAP) treatment. Sleep 18:172–179

    PubMed  CAS  Google Scholar 

  26. Lindberg E, Berne C, Elmasry A, Hedner J, Janson C (2006) CPAP treatment of a population-based sample—what are the benefits and the treatment compliance? Sleep Med 7:553–560

    Article  PubMed  Google Scholar 

  27. Mooe T, Rabben T, Wiklund U, Franklin KA, Eriksson P (1996) Sleep-disordered breathing in men with coronary artery disease. Chest 109:659–663

    PubMed  CAS  Google Scholar 

  28. Mooe T, Rabben T, Wiklund U, Franklin KA, Eriksson P (1996) Sleep-disordered breathing in women: occurrence and association with coronary disease. Am J Med 101:251–256

    Article  PubMed  CAS  Google Scholar 

  29. Kraiczi H, Caidahl K, Samuelsson A, Peker Y, Hedner J (2001) Impairment of vascular endothelial function and left ventricular filling: association with the severity of apnea-induced hypoxemia during sleep. Chest 119:1085–1091

    Article  PubMed  CAS  Google Scholar 

  30. Okura Y, Brink M, Zahid AA, Anwar A, Delafontaine P (2001) Decreased expression of insulin-like growth factor-1 and apoptosis of vascular smooth muscle cells in human atherosclerotic plaque. J Mol Cell Cardiol 33:1777–1789

    Article  PubMed  CAS  Google Scholar 

  31. Laughlin GA, Barrett Connor E, Crıquı MH, Kritz-Silverstein D (2004) The prospective association of serum insulin-like growth factor I (IGF-I) and IGF-I binding protein-1 levels with all-cause and cardiovascular disease mortality in older adults: The Rancho Bernardo Study. J Clin Endocrinol Metab 89:114–120

    Article  PubMed  CAS  Google Scholar 

  32. Sandhu MS (2005) Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology. Endocr Dev 9:44–54

    PubMed  CAS  Google Scholar 

  33. Poykko SM, Ukkola O, Kauma H, Kellokoski E, Horkko S, Kesaniemi A (2005) The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes. Diabetologia 48:309–316

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pulmonary Medicine, School of Medicine, University of Uludag, Bursa, Turkey

    Ahmet Ursavas, Mehmet Karadag, Basak Burgazlioglu, Funda Coskun & R. Oktay Gozu

  2. Department of Biochemistry, School of Medicine, University Of Uludag, Bursa, Turkey

    Yesim Ozarda Ilcol

  3. Department of Biostatistics, School of Medicine, University Of Uludag, Bursa, Turkey

    Ilker Ercan

  4. Uludağ Üniversitesi Tıp Fakültesi, Göğüs Hastalıkları ve Tüberküloz AD, 16059, Görükle, Bursa, Turkey

    Ahmet Ursavas

Authors
  1. Ahmet Ursavas
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mehmet Karadag
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Yesim Ozarda Ilcol
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ilker Ercan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Basak Burgazlioglu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Funda Coskun
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. R. Oktay Gozu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ahmet Ursavas.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ursavas, A., Karadag, M., Ilcol, Y.O. et al. Low Level of IGF-1 in Obesity May Be Related to Obstructive Sleep Apnea Syndrome. Lung 185, 309–314 (2007). https://doi.org/10.1007/s00408-007-9026-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00408-007-9026-x

Keywords

Search

Navigation