Abstract
Bilateral diaphragmatic paralysis (BDP) is usually caused by anatomic lesions of both phrenic nerves or generalized neurologic diseases. BDP has also been observed during and after infections, associated with mediastinal tumors, or may have an idiopathic etiology. A 57-year-old woman with breast cancer had progressive dyspnea that worsened when in the supine position. Lung function tests and phrenic nerve stimulation revealed bilateral diaphragmatic paralysis. Clinical suspicion of BDP should always be raised in patients suffering from progressive dyspnea and orthopnea. Determination of (VC) when standing and in the supine position and measurement of trandiaphragmatic pressure should reveal this uncommon diagnosis.
Similar content being viewed by others
References
Adams RD, Richardson EP (1970) Case records of the Massachusetts General Hospital. N Engl J Med 283:806–814
Bolton CF, Young GB Neurological complications in critically ill patients. In: Aminoff MJ, ed. Neurology and Medicine. Churchill Livingstone, New York. pp 713–727
Braun N, Arona N, Rochester D (1983) Respiratory muscles and pulmonary function in polimyositis and other proximal myopathies. Thorax 38:616–623
Croft PB, Urich H, Wilkonson M (1965) The incidence of carinomatous neuromyopathy in patients with various types of carcinomas. Brain 88:427–434
Dalmau J, Posner JB (1994) Neurologic paraneoplastic antibodies (anti-Yo; anti-Hu; anti-Ri): The case for a nomenclature based on antibody and antigen specificity. Neurology 44:2241–2246
Davison A, Mulvey D, Green M (1992) Idiopathic diaphragm weakness. Br Med J 304:492–494
Grauss F, Elkon KB, Cordon-Cardo C (1986) Sensory neuropathy and small-cell lung cancer. Antineuronal antibody that also reacts with the tumor. Am J Med 80:45–52
Gregory RP, Lohn L, Newsom-Davis J (1990) Recurrent isolated phrenic nerves palsies: a variant of brachial neuritis? Thorax 45:420–421
Hawke SH, Davies L, Pamhlett R (1991) Vasculitis neuropathy. A clinical and pathologic study. Brain 114:2175–2190
Lahrmann H, Grisold W, Authier FJ, Zifko UA (1999) Neuralgic amyotrophy with phrenic nerve involvement. Muscle Nerve 22:437–442
Laroche CM, Cairns T, Moxham J, Green M (1988) Hypothyroidism presenting with respiratory muscle weakness. Am Rev Respir Dis 138:472–474
Leys K, Lang B, Johnston I (1991) Calcium channel autoantibodies in the Lambert–Eaton myastenic syndrome. Ann Neurol 29:307–314
McCool FD, Mead J (1989) Dyspnea on immersion: Mechanisms in patients with bilateral diaphragmatic paralysis. Am Rev Respir Dis 139(1):275–276
Mier-Jedrzejowicz AK, Brophy C, Green M (1988) Respiratory muscle function in myasthenia gravis. Am Rev Respir Dis 138:867–873
Mulvey DA, Aquilina RJ, Elliot MW, Moxham J, Green M (1993) Diaphragmatic dysfunction in neuralgic amyotrophy: an eletrophysiologic evaluation of 16 patients presenting with dyspnea. Am Rev Respir Dis 147:66–71
Mumenthaler M (1990) Neuromuscular diseases which lead to respiratory insufficiency. Ther Umsch 47:872–877
Norvin ET, Passamonte PM, Sunderrajan RV (1984) Bilateral diaphragmatic paralysis as possible paraneoplastic syndrome from renal cell carcinoma. Am Rev Respir Dis 129:507– 509
Parhad IM, Clark AW, Barron KD, Staunton SB, et al. (1978) Diaphragmatic paralysis in motor neurone disease: report of two cases and review of the literature. Neurology 28:18–22
Posner JB (1995) Paraneoplastic syndromes. In: Neurologic complications of cancer. Contemporary Neurology Series: 45: F.A. Davis Co. Philadelphia, chap 15
Rijnders B, Decramer M (2000) Reversibility of paraneoplastic bilateral diaphragmatic paralysis after nephrectomy for renal cell carcinoma. Ann Oncol 11:221–225
Riley E (1962) Idiopathic diaphragmatic paralysis, a report of eight cases. Am J Med 32:404–415
Rosenfeld CS, Posner JB (1991) Paraneoplastic motor neuron disease. In: Rowland LP, (ed). Amyotrophic Lateral Sclerosis and other Motor Neurone Diseases. Raven Press, New York, pp 445–449
Tsairis P, Dyck P, Mulder D (1972) Natural history of brachial plexus neuropathy. Arch Neural 27:109–117
Turner JWA, Parsonage MJ (1957) Neuralgic amyotrophy (paralytic brachialis neuritis) with special reference to prognosis. Lancet 2:209–212
Zifko U, Chen R, Remtulla H, et al. (1996) Respiratory electrophysiological studies of the diaphragm in Guillaih–Barre syndrome. J Neurosurg Psychiatry 60:191–194
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Chroneou, A., Katsaounou, P., Gangadi, M. et al. An Unusual Cause of Dyspnea in a Patient with Relapsing Breast Cancer. Lung 184, 245–248 (2006). https://doi.org/10.1007/s00408-005-2583-y
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00408-005-2583-y