Skip to main content
SpringerLink
Log in

Long-term Follow-up of Pulmonary Function in Bronchial Asthma Patients Treated with Pranlukast

  • Published:
Lung Aims and scope Submit manuscript

Abstract

Clinical studies have shown that pranlukast, a selective cysteinyl leukotriene antagonist, is effective for bronchial asthma. In the present paper, we retrospectively analyzed long-term asthma control by pranlukast treatment in patients treated with inhaled corticosteroids. We analyzed medical records and asthma diaries of 21 patients (9 males, 12 females) (52.1 ± 3.5 years of age) with bronchial asthma who experienced increase of more than 10 L/min in peak expiratory flow in the first 4 weeks of treatment with pranlukast (450 mg/day) and were subsequently treated with pranlukast for more than 1 year. They all received inhaled corticosteroids (400–1600 µg/day of beclomethasone dipropionate or equivalent). We examined clinical control in terms of time course of self-monitored peak expiratory flow. During the analyzed period, the dose of inhaled corticosteroids was tapered in 4 patients, constant in 15 patients and increased in 2 patients. In 19 patients treated with unchanged or tapered dose of inhaled corticosteroids, improvement in the increase of mean PEF at 4-week treatment was maintained for 1 year. No difference in the add-on effect of pranlukast was observed in patients treated with less than 800 µg and more than or equal to 800 µg of inhaled corticosteroids. Four patients underwent reduction of inhaled corticosteroids in the analyzed period and PEF was well-maintained and even increased by pranlukast treatment. In 11 patients in whom data for 3 years were available, the improvement in PEF persisted for 3 years. Although the present investigation is a retrospective analysis, these data may suggest that pranlukast has no tachyphylaxis and its effect continues for more than 1 year.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4

Similar content being viewed by others

References

  1. InstitutionalAuthorNameAmerican Thoracic Society (1987) ArticleTitleStandards for the diagnosis and care of patients with chronic obstructive pulmonary disease (COPD) and asthma. Am Rev Respir Dis 136 225–244 Occurrence Handle3605835

    PubMed  Google Scholar 

  2. NC Barnes G Marone GU Di Maria S Visser I Utama SL Payne (1993) ArticleTitleA comparison of fluticasone propionate, 1 mg daily, with beclomethasone dipropionate, 2 mg daily, in the treatment of severe asthma. International Study Group. Eur Respir J 6 877–885

    Google Scholar 

  3. NC Barnes JC Pujet (1997) ArticleTitlePranlukast, a novel leukotriene receptor antagonist: results of the first European, placebo controlled, multicentre clinical study in asthma. Thorax 52 523–527 Occurrence Handle1:STN:280:ByiA2s7kvFc%3D Occurrence Handle9227718

    CAS  PubMed  Google Scholar 

  4. DH Broide (2001) ArticleTitleMolecular and cellular mechanisms of allergic disease. J Allergy Clin Immunol 108 S65–S71 Occurrence Handle10.1067/mai.2001.116436 Occurrence Handle1:CAS:528:DC%2BD3MXms1egt7k%3D Occurrence Handle11498675

    Article  CAS  PubMed  Google Scholar 

  5. WW Busse RF Lemanske Jr (2001) ArticleTitleAsthma. N Engl J Med 344 350–362 Occurrence Handle10.1056/NEJM200102013440507 Occurrence Handle1:CAS:528:DC%2BD3MXht1Wlu7k%3D Occurrence Handle11172168

    Article  CAS  PubMed  Google Scholar 

  6. JM Drazen E Israel PM O Byrne (1999) ArticleTitleTreatment of asthma with drugs modifying the leukotriene pathway. N Engl J Med 340 197–206 Occurrence Handle1:STN:280:DyaK1M7gtFyltQ%3D%3D Occurrence Handle9895400

    CAS  PubMed  Google Scholar 

  7. J Grossman I Faiferman JW Dubb DJ Tompson W Busse E Bronsky A Montanaro L Southern D Tinkelman (1997) ArticleTitleResults of the first U.S. double-blind, placebo-controlled, multicenter clinical study in asthma with pranlukast, a novel leukotriene receptor antagonist. J Asthma 34 321–328 Occurrence Handle1:STN:280:ByiA1Mzot1U%3D Occurrence Handle9250256

    CAS  PubMed  Google Scholar 

  8. H Kohrogi H Iwagoe K Fujii J Hamamoto K Fukuda N Hirata O Kawano M Matsumoto M Suga M Ando (1999) ArticleTitleThe role of cysteinyl leukotrienes in the pathogenesis of asthma: clinical study of leukotriene antagonist pranlukast for 1 year in moderate and severe asthma. Respirology 4 319–323 Occurrence Handle10.1046/j.1440-1843.1999.00199.x Occurrence Handle1:STN:280:DyaK1MvhvFGhuw%3D%3D Occurrence Handle10489683

    Article  CAS  PubMed  Google Scholar 

  9. M Laviolette K Malmstrom S Lu P Chervinsky JC Pujet I Peszek J Zhang TF Reiss (1999) ArticleTitleMontelukast added to inhaled beclomethasone in treatment of asthma. Montelukast/Beclomethasone Additivity Group. Am J Respir Crit Care Med 160 1862–1868 Occurrence Handle1:STN:280:DC%2BD3c%2Fls1ehsQ%3D%3D Occurrence Handle10588598

    CAS  PubMed  Google Scholar 

  10. National Heart, Lung, and Blood Institute, National Institutes of Health (1995) Establish medication plans for long-term management. In: Global Initiative for Asthma: Global Strategy for Asthma Management and Prevention. NHLBI/WHO Workshop Report. NIH Publications no. 95-3659. National Institutes of Health, Bethesda, 77–102

  11. Y Obase T Shimoda S Tomari K Mitsuta C Fukushima T Kawano H Matsuse S Kohno (2001) ArticleTitleEfficacy and safety of long-term treatment of asthmatic patients with pranlukast, a cysteinyl-leukotriene-receptor antagonist: four-year follow-up study. Ann Allergy Asthma Immunol 87 43–47 Occurrence Handle1:CAS:528:DC%2BD3MXlvVKisrs%3D

    CAS  Google Scholar 

  12. DB Price D Hernandez P Magyar et al. (2003) ArticleTitleRandomised controlled trial of montelukast plus inhaled budesonide versus double-dose inhaled budesonide in adult patients with asthma. Thorax 58 211–216 Occurrence Handle10.1136/thorax.58.3.211 Occurrence Handle1:STN:280:DC%2BD3s7hs1GgtQ%3D%3D Occurrence Handle12612295

    Article  CAS  PubMed  Google Scholar 

  13. DS Robinson D Campbell PJ Barnes (2001) ArticleTitleAddition of leukotriene antagonists to therapy in chronic persisitent asthma: a randomized double-blind placebo-controlled trial. Lancet 357 2007–2011 Occurrence Handle10.1016/S0140-6736(00)05113-8 Occurrence Handle1:CAS:528:DC%2BD3MXks1Oisb0%3D Occurrence Handle11438132

    Article  CAS  PubMed  Google Scholar 

  14. LJ Rosenwasser (1999) ArticleTitleLeukotriene modifiers: new drugs, old and new reactions. J Allergy Clin Immunol 103 374–375 Occurrence Handle1:STN:280:DyaK1M7mvFWhuw%3D%3D Occurrence Handle10069868

    CAS  PubMed  Google Scholar 

  15. S Suissa P Ernst (2001) ArticleTitleInhaled corticosteroids: impact on asthma morbidity and mortality. J Allergy Clin Immunol 107 937–944 Occurrence Handle10.1067/mai.2001.115653 Occurrence Handle1:CAS:528:DC%2BD3MXkvFelsrk%3D Occurrence Handle11398069

    Article  CAS  PubMed  Google Scholar 

  16. J Tamaoki M Kondo N Sakai J Nakata H Takemura A Nagai T Takizawa K Konno (1997) ArticleTitleLeukotriene antagonist prevents exacerbation of asthma during reduction of high-dose inhaled corticosteroid. Am J Respir Crit Care Med 155 1235–1240 Occurrence Handle1:STN:280:ByiB2MfovV0%3D Occurrence Handle9105060

    CAS  PubMed  Google Scholar 

  17. SH Yoo SH Park JS Song KH Kang CS Park JH Yoo BW Choi MH Hahn (2001) ArticleTitleClinical effects of pranlukast, an oral leukotriene receptor antagonist, in mild-to-moderate asthma: a 4-week randomized multicentre controlled trial. Respirology 6 15–21 Occurrence Handle10.1046/j.1440-1843.2001.00291.x Occurrence Handle1:STN:280:DC%2BD3M3os1yrtQ%3D%3D Occurrence Handle11264758

    Article  CAS  PubMed  Google Scholar 

  18. K Wada K Minoguchi Y Kohno et al. (2000) ArticleTitleEffect of a leukotriene receptor antagonist, pranlukast hydrate, on airway inflammation and airway hyperresponsiveness in patients with moderate to severe asthma. Allergol Int 49 63–68 Occurrence Handle10.1046/j.1440-1592.2000.00160.x Occurrence Handle1:CAS:528:DC%2BD3cXislGntr4%3D

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine and Molecular Therapeutics, The University of Tokushima School of Medicine, Tokushima, 770-8503, Japan

    H. Yanagawa, A. Sugita, M. Azuma, H. Ogawa, C. Kitamuro, K. Yoneda, K. Shinkawa, K. Tani & S. Sone

  2. Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital, Kuramoto-cho 2, Tokushima, 770-8503, Japan

    H. Yanagawa

Authors
  1. H. Yanagawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Sugita
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. Azuma
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. Ogawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C. Kitamuro
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. K. Yoneda
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. K. Shinkawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. K. Tani
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. S. Sone
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to H. Yanagawa.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yanagawa, H., Sugita, A., Azuma, M. et al. Long-term Follow-up of Pulmonary Function in Bronchial Asthma Patients Treated with Pranlukast . Lung 182, 51–58 (2004). https://doi.org/10.1007/s00408-003-1044-8

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00408-003-1044-8

Keywords

Search

Navigation