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Expression of KIT (CD117) in Biphasic Pulmonary Blastoma. Novel Data on Histogenesis

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Abstract

Biphasic pulmonary blastoma (BPB) is a rare primary neoplasm of the lung and its histogenesis is still uncertain. It has been proposed that BPB is derived from mesoderm or endoderm. Others suggested an origin from a single pluripotential cell. We present a case of a BPB with emphasis on expression of the stem cell factor receptor KIT (CD117). We describe a 61-year-old male patient with a BPB of the upper right lobe. Immunohistochemical analysis was performed using a panel of several antibodies including anti-CD117. Strong cytoplasmic expression of CD117 was found in the epithelium (cytokeratin-positive) as well as in the spindle cells (cytokeratin-negative). Expression of CD117 in both mesenchymal and epithelial cells suggests a single origin and supports the idea that BPB arises from a pluripotential cell that can differentiate into both stromal and epithelial morphologies. The role of CD117 in the pathogenesis of BPB and its possible therapeutic relevance require further investigation.

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Authors and Affiliations

  1. Institute of Pathology, Johannes Gutenberg-University, Mainz, Germany

    T. Hansen, F. Bittinger & C. J. Kirkpatrick

  2. Department of Pulmonary Medicine, St. Hildegardis Hospital, Mainz, Germany

    C. Kortsik & B. Wagner

Authors
  1. T. Hansen
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  2. F. Bittinger
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  3. C. Kortsik
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  4. B. Wagner
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  5. C. J. Kirkpatrick
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Correspondence to T. Hansen.

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Hansen, T., Bittinger, F., Kortsik, C. et al. Expression of KIT (CD117) in Biphasic Pulmonary Blastoma. Novel Data on Histogenesis . Lung 181, 193–200 (2003). https://doi.org/10.1007/s00408-003-1021-2

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  • DOI: https://doi.org/10.1007/s00408-003-1021-2

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