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Usefulness of Technetium-99m Hexamethylpropylene Amine Oxime Lung Scan to Detect Subclinical Lung Injury in Patients with Chronic Renal Failure

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Abstract

We used technetium-99m hexamethylpropylene amine oxime (Tc-99m HMPAO) lung scan to detect subclinical lung injury in patients with chronic renal failure (CRF), on regular hemodialysis (HD), who had normal chest X-ray findings (CXR) and pulmonary function test (PFT). The degree of pulmonary vascular endothelium damage was represented as lung/liver uptake ratios (L/L ratios) calculated by Tc-99m HMPAO lung scan. The L/L ratios of the 20 male CRF patients on HD with normal CXR and PFT were compared with those of the 20 male normal controls. The results show that the L/L ratios on Tc-99m HMPAO lung scans were significantly higher in CRF patients on HD (1.06 ± 0.55) than those in normal controls (0.34 ± 0.09). Using a cut-off value of 0.50, 18/20 [90%] CRF patients had abnormally increased L/L ratios. Our findings concluded that the pulmonary vascular endothelium damage represented as significantly increased L/L ratios on Tc-99m HMPAO lung scan in CRF patients on HD with normal CXR and PFT. In addition, Tc-99m HMPAO lung scan has the potential to be a sensitive, objective and noninvasive method to detect subclinical lung injury of CRF patients on HD, which is different from the traditional studies such as CXR or PFT.

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Authors and Affiliations

  1. Department of Urology, China Medical College Hospital, Taichung, Taiwan

    C. -H. Chang & H. -C. Wu

  2. Graduate Institute of Bioinformatics, Taichung Healthcare and Management University, Taichung, Taiwan

    J. -J. P. Tsai

  3. Department Family Medicine, China Medical College Hospital, Taichung, Taiwan

    C. -C. Lin

  4. Department of Medical Research, China Medical College Hospital, No. 2, Yuh Der Road, Taichung 404, Taiwan

    C. -C. Lee & A. Kao

Authors
  1. C. -H. Chang
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  2. H. -C. Wu
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  3. J. -J. P. Tsai
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  4. C. -C. Lin
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  5. C. -C. Lee
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  6. A. Kao
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Correspondence to A. Kao.

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Chang, CH., Wu, HC., Tsai, JJ. et al. Usefulness of Technetium-99m Hexamethylpropylene Amine Oxime Lung Scan to Detect Subclinical Lung Injury in Patients with Chronic Renal Failure . Lung 181, 97–101 (2003). https://doi.org/10.1007/s00408-003-1010-5

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  • DOI: https://doi.org/10.1007/s00408-003-1010-5

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