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Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

The tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the development of malformations in various organs including the brain. A polymorphism in the TSC2 gene has been found to be increased in gangliogliomas, a lesion which is associated with disturbed neuro-glial cell migration pattern. Since these pathomorphological changes are compatible with disturbed neuronal migration in schizophrenic brains, we investigated this polymorphism in 130 families with a schizophrenic index patient. A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia.

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Authors and Affiliations

  1. Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany, , , , , , DE

    Rene Przkora, Andreas von Deimling & Otmar D. Wiestler

  2. Department of Psychiatry, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, D-53105 Bonn, Germany, , , , , , DE

    P. Falkai, Marcella Rietschel, Wolfgang Maier & Thomas A. Bayer

  3. State Mental Hospital Haar, Vockestrasse 72, D-85540 Haar, Germany, , , , , , DE

    Margot Albus

Authors
  1. Rene Przkora
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  2. P. Falkai
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  3. Andreas von Deimling
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  4. Otmar D. Wiestler
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  5. Margot Albus
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  6. Marcella Rietschel
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  7. Wolfgang Maier
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  8. Thomas A. Bayer
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Additional information

Received: 16 April 1998 / Accepted: 13 October 1998

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Przkora, R., Falkai, P., von Deimling, A. et al. Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia. European Archives of Psychiatry and Clinical Neurosciences 248, 314–315 (1998). https://doi.org/10.1007/s004060050056

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  • DOI: https://doi.org/10.1007/s004060050056

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