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History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia

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European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

Abstract

Abnormalities in subcortical brain structures may reflect higher suicide risk in mood disorders, but less is known about its associations for schizophrenia. This cross-sectional imaging study aimed to explore whether the history of suicide attempts was associated with subcortical changes among individuals with schizophrenia. We recruited 44 individuals with schizophrenia and a history of suicide attempts (SZ-SA) and 44 individuals with schizophrenia but without a history of suicide attempts (SZ-NSA) and 44 healthy controls. Linear regression showed that SZ-SA had smaller volumes of the hippocampus (Cohen’s d = −0.72), the amygdala (Cohen’s d = −0.69), and some nuclei of the amygdala (Cohen’s d, −0.57 to −0.72) than SZ-NSA after adjusting for age, sex, illness phase, and intracranial volume. There was no difference in the volume of the subfields of the hippocampus. It suggests the history of suicide attempts is associated with subcortical volume alterations in schizophrenia.

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Funding

This work was supported by the National Natural Science Foundation of China [Y. Tan, 82171507, 81761128021; S. Chen, 82001415], the National Institutes of Health [L. E. Hong, R01MH112180]. Funders have no roles in data analysis, interpretation of the findings, or decision to publish the findings.

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Authors and Affiliations

  1. Peking University HuiLongGuan Clinical Medical School, Beijing HuiLongGuan Hospital, Beijing, 100096, People’s Republic of China

    Yi Yin, Jinghui Tong, Junchao Huang, Leilei Wang, Baopeng Tian, Song Chen, Shuping Tan, Zhiren Wang, Ting Yu, Yanli Li, Yongsheng Tong, Fengmei Fan & Yunlong Tan

  2. Beijing Suicide Research and Prevention Center, WHO Collaborating Center for Research and Training in Suicide Prevention, Beijing, People’s Republic of China

    Yongsheng Tong

  3. Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA

    Peter Kochunov & L. Elliot Hong

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  1. Yi Yin
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  2. Jinghui Tong
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  3. Junchao Huang
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  4. Leilei Wang
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  10. Yanli Li
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  11. Yongsheng Tong
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  12. Fengmei Fan
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  13. Peter Kochunov
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  14. L. Elliot Hong
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  15. Yunlong Tan
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Contributions

Conceptualization: Y. Tan, L. E. Hong, and Y. Yin; Methodology: S. Chen, F. Fan, P. Kochunov, and Y. Tong; Investigation: J. Tong, J. Huang, L. Wang, B. Tian, S. Tan, Z. Wang, T. Yu, Y. Li; Data curation: Y. Yin, T. Yu, and F. Fan; Formal Analysis: Y. Yin; Visualization: Y. Yin; Validation: Y. Tan; Interpretation of results: Y. Yin and Y. Tan; Writing – original draft: Y. Yin and Y. Tan; Writing – review and editing: J. Tong, J. Huang, L. Wang, B. Tian, S. Chen, S. Tan, Z. Wang, T. Yu, Y. Li, Y. Tong, P. Kochunov, and L. E. Hong; Approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work: All authors; Funding acquisition: Y. Tan, S. Chen, and L. E. Hong; Supervision: Y. Tan.

Corresponding author

Correspondence to Yunlong Tan.

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Conflict of interest

Dr. Hong has received or is planning to receive research funding or consulting fees from Mitsubishi, Your Energy Systems LLC, Neuralstem, Taisho, Heptares, Pfizer, Sound Pharma, Luye Pharma, IGC Pharma, Takeda, and Regeneron. None was involved in the design, analysis, or outcomes of the study. Other authors declared that the research was conducted without any relationships that could be interpreted as a potential conflict of interest or financial conflict.

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Yin, Y., Tong, J., Huang, J. et al. History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia. Eur Arch Psychiatry Clin Neurosci 273, 921–930 (2023). https://doi.org/10.1007/s00406-023-01554-5

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