Skip to main content
SpringerLink
Log in

A distinct pattern of EEG and ECG changes associated with inhalational nitrous oxide’s rapid antidepressant effects

  • Letter to the Editor
  • Published:
European Archives of Psychiatry and Clinical Neuroscience Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

References

  1. Guimarães MC, Guimarães TM, Hallak JE et al (2021) Nitrous oxide as an adjunctive therapy in major depressive disorder: a randomized controlled double-blind pilot trial. Braz J Psychiatry 43:484–493. https://doi.org/10.1590/1516-4446-2020-1543

    Article  PubMed  PubMed Central  Google Scholar 

  2. Nagele P, Palanca BJ, Gott B et al (2021) A phase 2 trial of inhaled nitrous oxide for treatment-resistant major depression. Sci Transl Med 13:1376. https://doi.org/10.1126/scitranslmed.abe1376

    Article  CAS  Google Scholar 

  3. Jevtović-Todorović V, Todorović SM, Mennerick S et al (1998) Nitrous oxide (laughing gas) is an NMDA antagonist, neuroprotectant and neurotoxin. Nat Med 4:460–463. https://doi.org/10.1038/nm0498-460

    Article  PubMed  Google Scholar 

  4. Zarate CA, Singh JB, Carlson PJ et al (2006) A randomized trial of an N-methyl-d-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63:856–864. https://doi.org/10.1001/archpsyc.63.8.856

    Article  CAS  PubMed  Google Scholar 

  5. Izumi Y, Hsu F-F, Conway CR et al (2022) Nitrous oxide, a rapid antidepressant, has ketamine-like effects on excitatory transmission in adult hippocampus. Biol Psychiatry. https://doi.org/10.1016/j.biopsych.2022.06.016

    Article  PubMed  Google Scholar 

  6. Traber DL, Wilson RD, Priano LL (1970) Blockade of the hypertensive response to ketamine. Anesth Analg 49:420–426

    CAS  PubMed  Google Scholar 

  7. de la Salle S, Choueiry J, Shah D et al (2016) Effects of ketamine on resting-state EEG activity and their relationship to perceptual/dissociative symptoms in healthy humans. Front Pharmacol 7:348. https://doi.org/10.3389/fphar.2016.00348

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Riva-Posse P, Reiff CM, Edwards JA et al (2018) Blood pressure safety of subanesthetic ketamine for depression: a report on 684 infusions. J Affect Disord 236:291–297. https://doi.org/10.1016/j.jad.2018.02.025

    Article  CAS  PubMed  Google Scholar 

  9. Ip C-T, Olbrich S, Ganz M et al (2021) Pretreatment qEEG biomarkers for predicting pharmacological treatment outcome in major depressive disorder: independent validation from the NeuroPharm study. Eur Neuropsychopharmacol J Eur Coll Neuropsychopharmacol 49:101–112. https://doi.org/10.1016/j.euroneuro.2021.03.024

    Article  CAS  Google Scholar 

  10. Zehong C, Chin-Teng L, Weiping D et al (2019) Identifying ketamine responses in treatment-resistant depression using a wearable forehead EEG. IEEE Trans Biomed Eng 66:1668–1679. https://doi.org/10.1109/TBME.2018.2877651

    Article  Google Scholar 

Download references

Acknowledgements

We want to thank Atalia Adank, Anna Bankwitz, Annia Rüesch, and Christoph Hörmann for their help in recording electrophysiological measures.

Author information

Authors and Affiliations

  1. Department of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry Zürich, Lenggstrasse 31, P.O. Box 363, 8032, Zurich, Switzerland

    Golo Kronenberg, Annette Müller, Erich Seifritz & Sebastian Olbrich

Authors
  1. Golo Kronenberg
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Annette Müller
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Erich Seifritz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sebastian Olbrich
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sebastian Olbrich.

Ethics declarations

Conflict of interest

On behalf of all authors, the corresponding author states that there is no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kronenberg, G., Müller, A., Seifritz, E. et al. A distinct pattern of EEG and ECG changes associated with inhalational nitrous oxide’s rapid antidepressant effects. Eur Arch Psychiatry Clin Neurosci 273, 1395–1397 (2023). https://doi.org/10.1007/s00406-022-01502-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00406-022-01502-9

Search

Navigation