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The impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort

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Abstract

Parent history of severe mental illness (PHSMI) may have long-term consequences in adult offspring due to genetic and early environmental factors in preliminary studies. To compare the outcomes associated in subjects with PHSMI to those in patients without PHSMI. The participants with schizophrenia and schizoaffective disorders were recruited in the ongoing FACE-SZ cohort at a national level (10 expert centers) and evaluated with a 1-day-long standardized battery of clinician-rated scales and patient-reported outcomes. PHSMI was defined as history of schizophrenia or bipolar disorders in at least one parent and was included as explanatory variable in multivariate models. Of the 724 included patients, 78 (10.7%) subjects were classified in the PHSMI group. In multivariate analyses, PHSMI patients had a better insight into schizophrenia and the need for treatment and reported more often childhood trauma history compared to patients without PHSMI. More specifically, those with paternal history of SMI reported more severe outcomes (increased childhood physical and emotional abuses, comorbid major depression and psychiatric hospitalizations). PHSMI is associated with increased risk of childhood trauma, major depressive disorder and psychiatric hospitalization and better insight in individuals with schizophrenia. Specific public health prevention programs for parents with SMI should be developed to help protect children from pejorative psychiatric outcomes. PHSMI may also explain in part the association between better insight and increased depression in schizophrenia.

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Acknowledgements

Members of the FACE-SCZ Group: M. Andre: Fondation Fondamental; University Department of Adult Psychiatry, La Colombiere Hospital, CHU Montpellier, University of Montpellier 1, Inserm 1061, Montpellier, France. C. Andrieu-Haller: Fondation Fondamental; AP-HM, la Conception Hospital, Aix-Marseille Univ, School of medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service Research and Quality of Life Center, 27 Boulevard Jean Moulin, 13005 Marseille, France. B. Aouizerate: Fondation Fondamental; University Department of General Psychiatry, Charles Perrens Hospital, F-33076 Bordeaux, France; Laboratory of Nutrition and Integrative Neurobiology (UMR INRA 1286), University of Bordeaux, France. F. Berna: Fondation Fondamental; Strasbourg University Hospital, University of Strasbourg, INSERM U1114, Federation of Translational Psychiatry, Strasbourg, France. O. Blanc: Fondation Fondamental; Clermont-Ferrand University Hospital, rue montalembert, Clermont-Ferrand Cedex 1, France. E. Bourguignon: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. D. Capdevielle: Fondation Fondamental; University Department of Adult Psychiatry, La Colombiere Hospital, CHU Montpellier, University of Montpellier 1, Inserm 1061, Montpellier, France. I. Chereau-Boudet: Fondation Fondamental; Clermont-Ferrand University Hospital, rue montalembert, Clermont-Ferrand Cedex 1, France. J. Clauss-Kobayashi: Fondation Fondamental; Strasbourg University Hospital, University of Strasbourg, INSERM U1114, Federation of Translational Psychiatry, Strasbourg, France. N. Coulon: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France; Schizophrenia Expert Center and Psychosocial Rehabilitation Reference Center, Alpes Isère Hospital, Grenoble, France. R. Dassing: Fondation Fondamental; Strasbourg University Hospital, University of Strasbourg, INSERM U1114, Federation of Translational Psychiatry, Strasbourg, France. J.M. Dorey: Fondation Fondamental; INSERM, U1028; CNRS, UMR5292; University Lyon 1; Lyon Neuroscience Research Center, PSYR2 Team; le Vinatier Hospital, Schizophrenia Expert Centre, Lyon, F-69000, France. C. Dubertret: Fondation Fondamental; AP-HP; Department of Psychiatry, Louis Mourier Hospital, Colombes, France; Inserm UMR1266, Institute of Psychiatry and Neuroscience of Paris, University Paris Descartes, France; Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France. A. Esselin: Fondation Fondamental; Versailles Hospital, Department of Adult Psychiatry and Addictology, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France; DisAP-DevPsy-CESP, INSERM UMR1018, University of Paris-Saclay, University of Versailles Saint-Quentin-En-Yvelines 94807, Villejuif, France. G. Fond: Fondation Fondamental; AP-HM, la Conception Hospital, Aix-Marseille Univ, School of medicine - La Timone Medical Campus, EA 3279: CEReSS - Health Service Research and Quality of Life Center, 27 Boulevard Jean Moulin, 13005 Marseille, France. F. Gabayet: Fondation Fondamental; Schizophrenia Expert Center and Psychosocial Rehabilitation Reference Center, Alpes Isère Hospital, Grenoble, France. M. Jarroir: Fondation Fondamental; Versailles Hospital, Department of Adult Psychiatry and Addictology, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France; DisAP-DevPsy-CESP, INSERM UMR1018, University of Paris-Saclay, University of Versailles Saint-Quentin-En-Yvelines 94807, Villejuif, France. D. Lacelle: Fondation Fondamental; Clermont-Ferrand University Hospital, rue montalembert, Clermont-Ferrand Cedex 1, France. M. Leboyer: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. S. Leignier: Fondation Fondamental;Schizophrenia Expert Center and Psychosocial Rehabilitation Reference Center, Alpes Isère Hospital, Grenoble, France. P.M. Llorca: Fondation Fondamental; Clermont-Ferrand University Hospital, rue montalembert, Clermont-Ferrand Cedex 1, France. J. Mallet: Fondation Fondamental; AP-HP; Department of Psychiatry, Louis Mourier Hospital, Colombes, France; Inserm UMR1266, Institute of Psychiatry and Neuroscience of Paris, University Paris Descartes, France; Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France. E. Metairie: Fondation Fondamental; Department of Psychiatry (AP-HM), Sainte-Marguerite University Hospital, Marseille, France. T. Michel: Fondation Fondamental; University Department of Adult Psychiatry, La Colombiere Hospital, CHU Montpellier, University of Montpellier 1, Inserm 1061, Montpellier, France. D. Misdrahi: Fondation Fondamental; General and University Psychiatry Department, Charles Perrens Hospital, F-33076 Bordeaux; Univ. Bordeaux, CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France. C. Passerieux: Fondation Fondamental; Versailles Hospital, Department of Adult Psychiatry and Addictology, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France; DisAP-DevPsy-CESP, INSERM UMR1018, University of Paris-Saclay , University of Versailles Saint-Quentin-En-Yvelines 94807, Villejuif, France. J. Petrucci: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. B. Pignon: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. P. Peri: Fondation Fondamental; Department of Psychiatry (AP-HM), Sainte-Marguerite University Hospital, Marseille, France. C. Portalier: Fondation Fondamental; AP-HP; Department of Psychiatry, Louis Mourier Hospital, Colombes, France; Inserm UMR1266, Institute of Psychiatry and Neuroscience of Paris, University Paris Descartes, France; Université Paris Diderot, Sorbonne Paris Cité, Faculté de médecine, France. R. Rey: Fondation Fondamental; INSERM, U1028; CNRS, UMR5292; University Lyon 1; Lyon Neuroscience Research Center, PSYR2 Team; le Vinatier Hospital, Schizophrenia Expert Centre, Lyon, F-69000, France. C. Roman: Fondation Fondamental; Schizophrenia Expert Center and Psychosocial Rehabilitation Reference Center, Alpes Isère Hospital, Grenoble, France. B. Schorr: Fondation Fondamental; Strasbourg University Hospital, University of Strasbourg, INSERM U1114, Federation of Translational Psychiatry, Strasbourg, France. F. Schürhoff: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. A. Szöke: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. A. Tessier: Fondation Fondamental;General and University Psychiatry Department, Charles Perrens Hospital, F-33076 Bordeaux; Univ. Bordeaux, CNRS, INCIA, UMR 5287, F-33000 Bordeaux, France. M. Urbach: Fondation Fondamental; Versailles Hospital, Department of Adult Psychiatry and Addictology, Centre Hospitalier de Versailles, 177 rue de Versailles, 78157 Le Chesnay, France; DisAP-DevPsy-CESP, INSERM UMR1018, University of Paris-Saclay , University of Versailles Saint-Quentin-En-Yvelines 94807, Villejuif, France. G. Wachiche: Fondation Fondamental; INSERM U955, Translational Psychiatry Team, DHU Pe PSY, Centre Expert Schizophrénie, Pôle de Psychiatrie et d’Addictologie des Hôpitaux Universitaires Henri Mondor, Paris Est University, 40 rue de Mesly, 94000 Créteil, France. A. Zinetti-Bertschy: Fondation Fondamental; Strasbourg University Hospital, University of Strasbourg, INSERM U1114, Federation of Translational Psychiatry, Strasbourg, France.

Funding

This work was funded by Hôpitaux Universitaires de Marseille (AP-HM), Fondation FondaMental (RTRS Santé Mentale), by the Investissements d’Avenir program managed by the ANR under reference ANR-11-IDEX-0004-02 and ANR-10-COHO-10-01.

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Authors and Affiliations

  1. Fondation FondaMental, Créteil, France

    P. L. Sunhary de Verville, D. Etchecopar-etchart, R. Richieri, O. Godin, F. Schürhoff, F. Berna, B. Aouizerate, D. Capdevielle, I. Chereau, J. M. Dorey, C. Dubertret, N. Coulon, S. Leignier, J. Mallet, D. Misdrahi, C. Passerieux, R. Rey, A. Szoke, M. Urbach, M. Leboyer, P. M. Llorca, C. Lançon, L. Boyer & G. Fond

  2. Université Paris Est Creteil (UPEC), AP-HP, Hôpitaux Universitaires « H. Mondor », DMU IMPACT, INSERM, IMRB, Translational Neuropsychiatry, Fondation FondaMental, 94010, Creteil, France

    P. L. Sunhary de Verville, F. Schürhoff, A. Szoke & M. Leboyer

  3. Faculté de Médecine-Secteur Timone, EA 3279: CEReSS-Centre d’Etude et de Recherche sur les Services de Santé et la Qualité de vie, Aix-Marseille University, 27 Boulevard Jean Moulin, 13005, Marseille, France

    A. Garosi, P. L. Sunhary de Verville, D. Etchecopar-etchart, R. Richieri, C. Lançon, L. Boyer & G. Fond

  4. Centre Hospitalier Charles Perrens, Université de Bordeaux, 33076, Bordeaux, France

    P. L. Sunhary de Verville, B. Aouizerate & D. Misdrahi

  5. INSERM U1114, Fédération de Médecine Translationnelle de Strasbourg, Hôpitaux Universitaires de Strasbourg, Université de Strasbourg, Strasbourg, France

    P. L. Sunhary de Verville, F. Berna & J. Clauss-Kobayashi

  6. Service Universitaire de Psychiatrie Adulte, Hôpital la Colombière, CHRU Montpellier, Université Montpellier 1, Inserm 1061, Montpellier, France

    P. L. Sunhary de Verville & D. Capdevielle

  7. CMP B, CHU, EA 7280 Faculté de Médecine, Université d’Auvergne, BP 69, 63003, Clermont-Ferrand, France

    P. L. Sunhary de Verville, I. Chereau & P. M. Llorca

  8. INSERM U1028, CNRS UMR5292, Centre de Recherche en Neurosciences de Lyon, Université Claude Bernard Lyon 1, Equipe PSYR2, Centre Hospitalier le Vinatier, Pole Est, 95 Bd Pinel, BP 30039, 69678, Bron, France

    P. L. Sunhary de Verville, J. M. Dorey & R. Rey

  9. Department of Psychiatry, Faculté de Médecine, AP-HP, Louis Mourier Hospital, Université Paris Diderot, Sorbonne Paris Cité, Inserm U894, Colombes, France

    P. L. Sunhary de Verville, C. Dubertret & J. Mallet

  10. Centre Référent de Réhabilitation Psychosociale, CH Alpes Isère, Grenoble, France

    P. L. Sunhary de Verville, N. Coulon & S. Leignier

  11. Centre Hospitalier de Versailles, Service de psychiatrie et d’addictologie adulte, le Chesnay, EA 4047 HANDIReSP, UFR des Sciences de la Santé Simone veil, Université Versailles Saint-Quentin-en-Yvelines, Versailles, France

    P. L. Sunhary de Verville, C. Passerieux & M. Urbach

  12. INRA, NutriNeuro, University of Bordeaux, U1286, 33076, Bordeaux, France

    P. L. Sunhary de Verville & B. Aouizerate

  13. CNRS UMR 5287-INCIA, Pessac, France

    P. L. Sunhary de Verville & D. Misdrahi

  14. Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, 75013, Paris, France

    P. L. Sunhary de Verville & O. Godin

  15. INSERM, UMR_S 1136, Institut Pierre Louis d’Epidémiologie et de Santé Publique, 75013, Paris, France

    P. L. Sunhary de Verville & O. Godin

Authors
  1. A. Garosi
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  2. P. L. Sunhary de Verville
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  3. D. Etchecopar-etchart
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  4. R. Richieri
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  5. O. Godin
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  6. F. Schürhoff
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  7. F. Berna
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  8. B. Aouizerate
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  9. D. Capdevielle
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  10. I. Chereau
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  11. J. Clauss-Kobayashi
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  12. J. M. Dorey
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  13. C. Dubertret
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  14. N. Coulon
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  15. S. Leignier
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  16. J. Mallet
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  17. D. Misdrahi
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  18. C. Passerieux
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  19. R. Rey
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  20. A. Szoke
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  21. M. Urbach
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  22. M. Leboyer
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  23. P. M. Llorca
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  24. C. Lançon
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  25. L. Boyer
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  26. G. Fond
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Consortia

Collaborators : the FACE-SZ (Fonda Mental Academic Centers of Expertise for Schizophrenia) group

  • M. Andre
  • , C. Andrieu-Haller
  • , B. Aouizerate
  • , F. Berna
  • , O. Blanc
  • , E. Bourguignon
  • , D. Capdevielle
  • , I. Chereau-Boudet
  • , J. Clauss-Kobayashi
  • , N. Coulon
  • , R. Dassing
  • , J. M. Dorey
  • , C. Dubertret
  • , A. Esselin
  • , G. Fond
  • , F. Gabayet
  • , M. Jarroir
  • , D. Lacelle
  • , M. Leboyer
  • , S. Leignier
  • , P. M. Llorca
  • , J. Mallet
  • , E. Metairie
  • , T. Michel
  • , D. Misdrahi
  • , C. Passerieux
  • , J. Petrucci
  • , B. Pignon
  • , P. Peri
  • , C. Portalier
  • , R. Rey
  • , C. Roman
  • , B. Schorr
  • , F. Schürhoff
  • , A. Szöke
  • , A. Tessier
  • , M. Urbach
  • , G. Wachiche
  •  & A. Zinetti-Bertschy

Contributions

Conceptualization, GF and LB; methodology, GF; resources, GF; data curation, GF and PLS; writing—original draft preparation, AG, RR and LB and GF; writing—review and editing, all authors; supervision G.F.; funding acquisition, ML. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to G. Fond.

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Conflict of interest

The authors report no conflicts with the present article.

Additional information

Members of the FACE-SCZ Group are listed in the Acknowledgment section.

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Garosi, A., Sunhary de Verville, P.L., Etchecopar-etchart, D. et al. The impact of parent history of severe mental illness on schizophrenia outcomes: results from the real-world FACE-SZ cohort. Eur Arch Psychiatry Clin Neurosci 273, 825–837 (2023). https://doi.org/10.1007/s00406-022-01449-x

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  • DOI: https://doi.org/10.1007/s00406-022-01449-x

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