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Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness

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Abstract

Episodic memory ability relies on hippocampal-prefrontal connectivity. However, few studies have examined relationships between memory performance and white matter (WM) microstructure in hippocampal-prefrontal pathways in schizophrenia-spectrum disorder (SSDs). Here, we investigated these relationships in individuals with first-episode psychosis (FEP) and chronic schizophrenia-spectrum disorders (SSDs) using tractography analysis designed to interrogate the microstructure of WM tracts in the hippocampal-prefrontal pathway. Measures of WM microstructure (fractional anisotropy [FA], radial diffusivity [RD], and axial diffusivity [AD]) were obtained for 47 individuals with chronic SSDs, 28 FEP individuals, 52 older healthy controls, and 27 younger healthy controls. Tractography analysis was performed between the hippocampus and three targets involved in hippocampal–prefrontal connectivity (thalamus, amygdala, nucleus accumbens). Measures of WM microstructure were then examined in relation to episodic memory performance separately across each group. Both those with FEP and chronic SSDs demonstrated impaired episodic memory performance. However, abnormal WM microstructure was only observed in individuals with chronic SSDs. Abnormal WM microstructure in the hippocampal-thalamic pathway in the right hemisphere was associated with poorer memory performance in individuals with chronic SSDs. These findings suggest that disruptions in WM microstructure in the hippocampal–prefrontal pathway may contribute to memory impairments in individuals with chronic SSDs but not FEP.

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Acknowledgements

This study was funded by National Health and Medical Research Council (Grant numbers 1105825, 1150083 and 1177370) and Brain and Behavior Research Foundation (Grant number 21660).

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Authors and Affiliations

  1. Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton South, VIC, Australia

    Cassandra M. J. Wannan, Cali F. Bartholomeusz, Christos Pantelis, Maria A. Di Biase, Warda T. Syeda, Chad A. Bousman, Andrew Zalesky & Vanessa L. Cropley

  2. Orygen, The University of Melbourne, Parkville, VIC, Australia

    Cassandra M. J. Wannan, Cali F. Bartholomeusz & Patrick D. McGorry

  3. Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia

    Cassandra M. J. Wannan, Cali F. Bartholomeusz & Patrick D. McGorry

  4. North Western Mental Health, Melbourne Health, Parkville, VIC, Australia

    Christos Pantelis

  5. Florey Institute for Neurosciences and Mental Health, Parkville, VIC, Australia

    Christos Pantelis

  6. Computation Brain Anatomy (CoBrA) Laboratory, Douglas Hospital Research Centre, Montreal, Canada

    M. Mallar Chakravarty

  7. Departments of Psychiatry and Biological and Biomedical Engineering, McGill University, Montreal, Canada

    M. Mallar Chakravarty

  8. Departments of Medical Genetics, Psychiatry, and Physiology & Pharmacology, University of Calgary, Calgary, AB, Canada

    Chad A. Bousman

  9. Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, England

    Ian P. Everall

  10. The Melbourne School of Engineering, University of Melbourne, Parkville, VIC, Australia

    Andrew Zalesky

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  1. Cassandra M. J. Wannan
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  2. Cali F. Bartholomeusz
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Correspondence to Cassandra M. J. Wannan.

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Wannan, C.M.J., Bartholomeusz, C.F., Pantelis, C. et al. Disruptions in white matter microstructure associated with impaired visual associative memory in schizophrenia-spectrum illness. Eur Arch Psychiatry Clin Neurosci 272, 971–983 (2022). https://doi.org/10.1007/s00406-021-01333-0

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