References
Vesuna S, Kauvar IV, Richman E, Gore F, Oskotsky T, Sava-Segal C, Luo L, Malenka RC, Henderson JM, Nuyujukian P, Parvizi J, Deisseroth K (2020) Deep posteromedial cortical rhythm in dissociation. Nature 586:87–94
Hashimoto K (2019) Rapid-acting antidepressant ketamine, its metabolites and other candidates: a historical overview and future perspective. Psychiatry Clin Neurosci 73:613–627
Singh JB, Fedgchin M, Daly E, Xi L, Melman C, De Bruecker G, Tadic A, Sienaert P, Wiegand F, Manji H, Drevets WC, Van Nueten L (2016) Intravenous esketamine in adult treatment-resistant depression: a double-blind, double-randomization, placebo-controlled study. Biol Psychiatry 80:424–431
Leal GC, Bandeira ID, Correia-Melo FS, Telles M, Mello RP, Vieira F, Lima CS, Jesus-Nunes AP, Guerreiro-Costa LNF, Marback RF, Caliman-Fontes AT, Marques BLS, Bezerra MLO, Dias-Neto AL, Silva SS, Sampaio AS, Sanacora G, Turecki G, Loo C, Lacerda ALT, Quarantini LC (2020) Intravenous arketamine for treatment-resistant depression: open-label pilot study. Eur Arch Psychiatry Clin Neurosci. https://doi.org/10.1007/s00406-020-01110-5 (in press)
Grabski M, Borissova A, Marsh B, Morgan CA, Curran HV (2020) Ketamine as a mental health treatment: are acute psychoactive effects associated with outcomes? A systematic review. Behav Brain Res 395:112629
Javitt DC, Zukin SR (1991) Recent advances in the phencyclidine model of schizophrenia. Am J Psychiatry 148:1301–1308
Vann SD, Aggleton JP, Maguire EA (2009) What does the retrosplenial cortex do? Nat Rev Neurosci 10:792–802
Olney JW, Labruyere J, Price MT (1989) Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs. Science 244:1360–1362
Tian Z, Dong C, Fujita A, Fujita Y, Hashimoto K (2018) Expression of heat shock protein HSP-70 in the retrosplenial cortex of rat brain after administration of (R, S)-ketamine and (S)-ketamine, but not (R)-ketamine. Pharmacol Biochem Behav 172:17–21
Hiromitsu K, Shinoura N, Yamada R, Midorikawa A (2020) Dissociation of the subjective and objective bodies: out-of-body experiences following the development of a posterior cingulate lesion. J Neuropsychology 14:183–192
Acknowledgements
The author would like to thank my collaborators who are listed as the co-authors of our papers in the reference list. This study was supported by a grant from AMED, Japan (to K.H., JP20dm0107119).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
Dr. Hashimoto is the inventor of filed patent applications on “The use of R-ketamine in the treatment of psychiatric diseases”, “(S)-norketamine and salt thereof as pharmaceutical”, “R-ketamine and derivative thereof as a prophylactic or therapeutic agent for neurodegeneration disease or recognition function disorder”, “Preventive or therapeutic agent and pharmaceutical composition for inflammatory diseases or bone diseases”, and “R-ketamine and its derivatives as a preventive or therapeutic agent for a neurodevelopmental disorder” by the Chiba University. Dr. Hashimoto also declares that he has received research support and consultant from Dainippon Sumitomo, Otsuka, and Taisho.
Rights and permissions
About this article
Cite this article
Hashimoto, K. Neural rhythm in the retrosplenial cortex during ketamine-induced dissociation. Eur Arch Psychiatry Clin Neurosci 271, 583–585 (2021). https://doi.org/10.1007/s00406-020-01226-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00406-020-01226-8