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Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study

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Abstract

Characterizing the properties of brain networks across mood states seen in bipolar disorder (BP) can provide a deeper insight into the mechanisms involved in this type of affective disorder. In this study, graph theoretical methods were used to examine global, modular and nodal brain network topology in the resting state using functional magnetic resonance imaging data acquired from 95 participants, including those with bipolar depression (BPD; n = 30) and bipolar mania (BPM; n = 39) and healthy control (HC) subjects (n = 26). The threshold value of the individual subjects’ connectivity matrix varied from 0.15 to 0.30 with steps of 0.01. We found that: (1) at the global level, BP patients showed a significantly increased global efficiency and synchronization and a decreased path length; (2) at the nodal level, BP patients showed impaired nodal parameters, predominantly within the frontoparietal and limbic sub-network; (3) at the module level, BP patients were characterized by denser FCs (edges) between Module III (the front-parietal system) and Module V (limbic/paralimbic systems); (4) at the nodal level, the BPD and BPM groups showed state-specific differences in the orbital part of the left superior-frontal gyrus, right putamen, right parahippocampal gyrus and left fusiform gyrus. These results revealed abnormalities in topological organization in the whole brain, especially in the frontoparietal-limbic circuit in both BPD and BPM. These deficits may reflect the pathophysiological processes occurring in BP. In addition, state-specific regional nodal alterations in BP could potentially provide biomarkers of conversion across different mood states.

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Acknowledgements

The authors thank the study participants. This work was supported by the National Natural Science Foundation of China (Grant Nos. 91432301, 81671354, and 91732303) and the Anhui Provincial Natural Science Foundation for Distinguished Young Scholars (Grant No. 1808085J23).

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Authors and Affiliations

  1. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Hefei, 230022, Anhui Province, China

    Tongjian Bai, Yanghua Tian & Kai Wang

  2. Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, Hefei, 230022, China

    Li Zhang, Tongjian Bai, Gong-Jun Ji, Yanghua Tian & Kai Wang

  3. Anhui Mental Health Center, Hefei, Anhui Province, China

    Li Zhang, Huiling Wu & Aiguo Zhang

  4. Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, Hefei, 230022, China

    Gong-Jun Ji & Kai Wang

  5. Department of Medical Psychology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, China

    Gong-Jun Ji, Yanghua Tian & Kai Wang

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  1. Li Zhang
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  3. Aiguo Zhang
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Correspondence to Kai Wang.

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The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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The study was carried out in accordance with the recommendations of Human Brain Imaging Collection, Anhui Medical University Ethics Committee, and the protocol was approved by the Anhui Medical University Ethics Committee (No. 2019010). All subjects volunteered to participate in the study and signed a written informed consent form after receiving a full written and verbal explanation of the study.

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Zhang, L., Wu, H., Zhang, A. et al. Aberrant brain network topology in the frontoparietal-limbic circuit in bipolar disorder: a graph-theory study. Eur Arch Psychiatry Clin Neurosci 271, 1379–1391 (2021). https://doi.org/10.1007/s00406-020-01219-7

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  • DOI: https://doi.org/10.1007/s00406-020-01219-7

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