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Increased cerebellar–default-mode network connectivity at rest in obsessive–compulsive disorder

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Abstract

Abnormalities of the cerebellum and default-mode network (DMN) in patients with obsessive–compulsive disorder (OCD) have been widely reported. However, alterations of reciprocal functional connections between the cerebellum and DMN at rest in OCD remain unclear. Forty patients with OCD and 38 gender-, age-, and education-matched healthy controls (HCs) underwent resting-state functional magnetic resonance imaging scan. Seed-based functional connectivity (FC) and support vector machine (SVM) were applied to analyze the imaging data. Compared with HCs, patients with OCD exhibited increased FCs between the left Crus I–left superior medial prefrontal cortex (MPFC) and between the right Crus I–left superior MPFC, left middle MPFC, and left middle temporal gyrus (MTG). A significantly negative correlation was observed between the right Crus I–left MTG connectivity and the Yale–Brown Obsessive–Compulsive Scale compulsion subscale scores in the OCD group (r = − 0.476, p = 0.002, Bonferroni corrected). SVM classification analysis indicated that a combination of the left Crus I–left superior MPFC connectivity and the right Crus I–left middle MPFC connectivity can be used to discriminate patients with OCD from HCs with a sensitivity of 85.00%, specificity of 68.42%, and accuracy of 76.92%. Our study highlights the contribution of the cerebellar–DMN connectivity in OCD pathophysiology and provides new findings to OCD research.

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Acknowledgements

We thank all participants who willingly gave their time to provide data.

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    Authors and Affiliations

    1. Department of Psychiatry, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China

      Dan Lv, Yunhui Chen, Cuicui Jia, Lei Sun, Yuhua Wang, Zhenghai Sun, Yefu Wang & Ping Li

    2. Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China

      Yangpan Ou, Xiaoping Wang & Wenbin Guo

    3. Department of Radiology, The Second Xiangya Hospital of Central South University, Changsha, Hunan, 410011, China

      Ru Yang

    4. Henan Key Lab of Biological Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, 453002, China

      Zhaoxi Zhong

    5. Department of Radiology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang, China

      Guangfeng Zhang

    6. Department of Library, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China

      Wei Wang

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    This study was approved by the Research Ethics Committee of Qiqihar Medical University, China. All participants were informed regarding the study procedures and signed a written informed consent.

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    This study was supported by grants from Heilongjiang Natural Science Foundation of China (LH2019H064).

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    Dan Lv and Yangpan Ou contributed equally to this work.

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    Lv, D., Ou, Y., Chen, Y. et al. Increased cerebellar–default-mode network connectivity at rest in obsessive–compulsive disorder. Eur Arch Psychiatry Clin Neurosci 270, 1015–1024 (2020). https://doi.org/10.1007/s00406-019-01070-5

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