A proteomic signature associated to atypical antipsychotic response in schizophrenia patients: a pilot study

  • Daniel Martins-de-SouzaEmail author
  • Paul C. Guest
  • Johann Steiner
Short Communication


A major hurdle faced by most schizophrenia patients is the poor efficacy of current antipsychotic medications. This stems from a poor understanding of the underlying pathophysiology and the lack of biomarkers for the prediction of a positive medication response. By employing state-of-the-art proteomic analysis of blood plasma from 58 patients who were either drug-naive or drug-free at the time of sample collection, we identified potential biomarkers that were predictive of a positive response after 6 weeks of treatment with antipsychotics. Complement and coagulation cascades were the most over-represented biological pathways among these proteins, consistent with the importance of these processes in schizophrenia. Although preliminary, these findings are novel and may drive future efforts in the development of predictive tests for medication efficacy and thereby have a positive influence on disease outcome.


Biomarkers Drug response Atypical antipsychotics Proteins Proteome 



The Authors thank FAPESP (São Paulo Research Foundation—Grants 2013/08711-3 and 2017/25588-1), CNPq (The Brazilian National Council for Scientific and Technological Development, Grant 302453/2017-2), and Serrapilheira Institute (Grant number Serra-1709-16349).

Compliance with ethical standards

Conflict of interest

We declare no conflict of interest.

Supplementary material

406_2019_1002_MOESM1_ESM.xls (66 kb)
Supplementary material 1 (XLS 66 KB)


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Laboratory of Neuroproteomics, Department of Biochemistry and Tissue Biology, Institute of BiologyUniversity of Campinas (UNICAMP)CampinasBrazil
  2. 2.Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBION)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)São PauloBrazil
  3. 3.UNICAMP Neurobiology CenterCampinasBrazil
  4. 4.Laboratory of Translational PsychiatryUniversity of MagdeburgMagdeburgGermany
  5. 5.Department of Psychiatry and PsychotherapyUniversity of MagdeburgMagdeburgGermany
  6. 6.Center for Behavioral Brain Sciences (CBBS)MagdeburgGermany

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