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An update on cannabis use disorder with comment on the impact of policy related to therapeutic and recreational cannabis use

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Abstract

Confusion and controversy related to the potential for cannabis use to cause harm, or alternatively to provide benefit, continues globally. This issue has grown in intensity and importance with the increased recognition of the public health implications related to the escalation of the legalization of cannabis and cannabinoid products. This selective overview and commentary attempt to succinctly convey what is known about one potential consequence of cannabis use, the development of cannabis use disorder (CUD). Such knowledge may help guide a reasonable and objective public health perspective on the potential impact of cannabis use and CUD. Current scientific data and clinical observation strongly support the contention that cannabis use, like the use of other substances such as alcohol, opioids, stimulants, and tobacco, can develop into a use disorder (addiction) with important clinical consequences. Epidemiological data indicate that the majority of those who use cannabis do not have problems related to their use, but a substantial subset (10–30%) do report experiencing symptoms and consequences consistent with a CUD. Treatment seeking for CUD comprises a substantial proportion of all substance use treatment admissions, yet treatment response rates show much room for improvement. Changing cannabis policies related to its therapeutic and recreational use are likely to impact the development of CUD and its course; however, definitive data on such effects are not yet available. Clearly, the development of more effective prevention and treatment strategies is needed for those vulnerable to developing a CUD and for those with a CUD.

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References

  1. World Health Organization (1992) The ICD-10 classification of mental and behavioural disorders: Clinical descriptions and diagnostic guidelines. World Health Organization, Geneva

    Google Scholar 

  2. Zehra A, Burns J, Kure Liu C, Manza P, Wiers C, Volkow N, Wang G (2018) Cannabis addiction and the brain: a review. J Neuroimmune Pharmacol 1–15. https://doi.org/10.1007/s11481-018-9782-9

  3. APA (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington

    Google Scholar 

  4. Budney AJ, Roffman R, Stephens RS, Walker D (2007) Marijuana dependence and its treatment. Addict Sci Clin Pract 4(1):4–16

    Article  PubMed  PubMed Central  Google Scholar 

  5. Bloomfield MAP, Ashok AH, Volkow ND, Howes OD (2016) The effects of ∆9-tetrahydrocannabinol on the dopamine system. Nature 539:369. https://doi.org/10.1038/nature20153

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Vandrey R, Haney M (2009) Pharmacotherapy for cannabis dependence: how close are we? CNS Drugs 23(7):543–553

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. ElSohly (2005) Chemical constituents of marijuana: The complex mixture of natural cannabinoids. Life Sci 78:539–548

    Article  CAS  PubMed  Google Scholar 

  8. Budney AJ, Lile JA (2009) Moving beyond the cannabis controversy into the world of the cannabinoids. Int Rev Psychiatry 21(2):91–95. https://doi.org/10.1080/09540260902782729

    Article  PubMed  Google Scholar 

  9. Budney AJ, Borodovsky JT (2017) The potential impact of cannabis legalization on the development of cannabis use disorders. Prev Med. https://doi.org/10.1016/j.ypmed.2017.06.034

    Article  PubMed  PubMed Central  Google Scholar 

  10. Budney AJ, Vandrey RG, Hughes JR, Thostenson JD, Bursac Z (2008) Comparison of cannabis and tobacco withdrawal: severity and contribution to relapse. J Subst Abuse Treat 35(4):362–368. https://doi.org/10.1016/j.jsat.2008.01.002 pii]

    Article  PubMed  PubMed Central  Google Scholar 

  11. Hasin DS, Kerridge BT, Saha TD, Huang B, Pickering R, Smith SM, Jung J, Zhang H, Grant BF (2016) Prevalence and correlates of DSM-5 cannabis use disorder, 2012–2013: findings from the national epidemiologic survey on alcohol and related conditions–III. Am J Psychiatry 173(6):588–599. https://doi.org/10.1176/appi.ajp.2015.15070907

    Article  PubMed  PubMed Central  Google Scholar 

  12. WHO (2016) The Health and social effects of nonmedical cannabis use. Geneva, Switzerland

    Google Scholar 

  13. UNODC (2018) World drug report: pre-briefing to the member states. United Nations Office on Drugs and Crime, Vienna

    Google Scholar 

  14. SAMHSA (2017) Results from the 2016 national survey on drug use and health: detailed tables. Prevalence estimates, standard Errors, P Values, and sample sizes. Substance Abuse and Mental Health Services Administration, Center for Behavioral Health Statistics and Quality, Rockville

    Google Scholar 

  15. Mauro PM, Carliner H, Brown QL, Hasin DS, Shmulewitz D, Rahim-Juwel R, Sarvet AL, Wall MM, Martins SS (2018) Age differences in daily and nondaily cannabis use in the United States, 2002–2014. J Stud Alcohol Drugs 79(3):423–431. https://doi.org/10.15288/jsad.2018.79.423

    Article  PubMed  PubMed Central  Google Scholar 

  16. Degenhardt L, Ferrari AJ, Calabria B, Hall W, Norman RE, McGrath J, Flaxman AD, Engell RE, Freedman GD, Whiteford HA, Vos T (2013) The global epidemiology and contribution of cannabis use and dependence to the global burden of disease: results from the GBD 2010 Study. Plos ONE 8(10):e76635. https://doi.org/10.1371/journal.pone.0076635

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Pabst A, Kraus L, Gomes de Matos E, Piontek D (2013) Substance use and substance use disorders in Germany in 2012. SUCHT 59:321–331

    Article  Google Scholar 

  18. Teesson M, Slade T, Swift W, Mills K, Memedovic S, Mewton L, Grove R, Newton N, Hall W (2012) Prevalence, correlates and comorbidity of DSM-IV cannabis use and cannabis use disorders in Australia. Aust N Z J Psychiatry 46(12):1182–1192

    Article  PubMed  Google Scholar 

  19. Grucza RA, Agrawal A, Bierut LJ (2016) NESARC Findings on increased prevalence of marijuana use disorders—reply consistent with other sources of information. JAMA Psychiatry 73(5):532–533. https://doi.org/10.1001/jamapsychiatry.2016.0244

    Article  PubMed  Google Scholar 

  20. Hasin DS, Saha TD, Kerridge BT, Goldstein RB, Chou SP, Zhang H, Jung J, Pickering RP, Ruan WJ, Smith SM, Huang B, Grant BF (2015) Prevalence of marijuana use disorders in the United States between 2001–2002 and 2012–2013. JAMA Psychiatry 72(12):1235–1242. https://doi.org/10.1001/jamapsychiatry.2015.1858

    Article  PubMed  PubMed Central  Google Scholar 

  21. Grucza RA, Agrawal A, Krauss MJ, Cavazos-Rehg PA, Bierut LJ (2016) Recent trends in the prevalence of marijuana use and associated disorders in the United States. JAMA Psychiatry 73(3):300–301. https://doi.org/10.1001/jamapsychiatry.2015.3111

    Article  PubMed  PubMed Central  Google Scholar 

  22. Grant BF, Chou SP, Saha TD, Pickering RP, Kerridge BT, Ruan WJ, Huang B, Jung J, Zhang H, Fan A, Hasin DS (2017) Prevalence of 12-month alcohol use, high-risk drinking, and DSM-IV alcohol use disorder in the United States, 2001–2002 to 2012–2013: results from the national epidemiologic survey on alcohol and related conditions. JAMA Psychiatry 74(9):911–923. https://doi.org/10.1001/jamapsychiatry.2017.2161

    Article  PubMed  PubMed Central  Google Scholar 

  23. Chou SP, Goldstein RB, Smith SM, Huang B, Ruan WJ, Zhang H, Jung J, Saha TD, Pickering RP, Grant BF (2016) The epidemiology of DSM-5 nicotine use disorder: results from the national epidemiologic survey on alcohol and related conditions-III. J Clin Psychiatry 77(10):1404–1412. https://doi.org/10.4088/JCP.15m10114

    Article  PubMed  PubMed Central  Google Scholar 

  24. Budney AJ (2006) Are specific dependence criteria necessary for different substances: how can research on cannabis inform this issue? Addiction 101:125–133

    Article  PubMed  Google Scholar 

  25. Shmulewitz D, Greene ER, Hasin D (2015) Commonalities and differences across substance use disorders: phenomenological and epidemiological aspects. Alcohol Clin Exp Res 39(10):1878–1900. https://doi.org/10.1111/acer.12838

    Article  PubMed  PubMed Central  Google Scholar 

  26. Budney AJ, Hughes JR (2006) The cannabis withdrawal syndrome. Curr Opin Psychiatry 19(3):233–238

    Article  PubMed  Google Scholar 

  27. Peer K, Rennert L, Lynch KG, Farrer L, Gelernter J, Kranzler HR (2013) Prevalence of DSM-IV and DSM-5 alcohol, cocaine, opioid, and cannabis use disorders in a largely substance dependent sample. Drug Alcohol Depend 127(0):215–219

    Article  PubMed  Google Scholar 

  28. Kerridge BT, Pickering R, Chou P, Saha TD, Hasin DS (2018) DSM-5 cannabis use disorder in the national epidemiologic survey on alcohol and related conditions-III: gender-specific profiles. Addict Behav 76:52–60

    Article  PubMed  Google Scholar 

  29. Kimbrel N, Meyer E, DeBeer B, Gulliver S, Morissette S (2018) The impact of cannabis use disorder on suicidal and nonsuicidal self-injury in Iraq/Afghanistan-era veterans with and without mental health disorders. Suicide Life Threat Behav 48(2):140–148

    Article  PubMed  Google Scholar 

  30. Campbell CI, Bahorik AL, Kline-Simon AH, Satre DD (2017) The role of marijuana use disorder in predicting emergency department and inpatient encounters: a retrospective cohort study. Drug Alcohol Depend 178:170–175

    Article  PubMed  PubMed Central  Google Scholar 

  31. Crean RD, Crane NA, Mason BJ (2011) An evidence based review of acute and long-term effects of cannabis use on executive cognitive functions. J Addict Med 5(1):1–8. https://doi.org/10.1097/ADM.0b013e31820c23fa

    Article  PubMed  PubMed Central  Google Scholar 

  32. Kowal MA, van Steenbergen H, Colzato LS, Hazekamp A, van der Wee NJA, Manai M, Durieux J, Hommel B (2015) Dose-dependent effects of cannabis on the neural correlates of error monitoring in frequent cannabis users. Eur Neuropsychopharmacol 25(11):1943–1953

    Article  CAS  PubMed  Google Scholar 

  33. Volkow ND, Swanson JM, Evins AE, DeLisi LE, Meier MH, Gonzalez R, Bloomfield MA, Curran HV, Baler R (2016) Effects of cannabis use on human behavior, including cognition, motivation, and psychosis: a review. JAMA Psychiatry 73(3):292–297. https://doi.org/10.1001/jamapsychiatry.2015.3278

    Article  PubMed  Google Scholar 

  34. Solowij N, Battisti R (2008) The chronic effects of cannabis on memory in humans: a review. Curr Drug Abuse Rev 1(1):81–98

    Article  PubMed  Google Scholar 

  35. Lorenzetti V, Alonso-Lana S, Youssef GJ, Verdejo-Garcia A, Suo C, Cousijn J, Takagi M, Yücel M, Solowij N (2016) Adolescent cannabis use: what is the evidence for functional brain alteration? Curr Pharm Des 22(42):6353–6365. https://doi.org/10.2174/1381612822666160805155922

    Article  CAS  PubMed  Google Scholar 

  36. Jernigan TL, Brown SA, Coordinators AC (2018) Introduction. Dev Cogn Neurosci 32: The Adolescent Brain Cognitive Development (ABCD) Consortium: Rationale, aims, and assessment strategy:1–3

  37. Farmer RFK, Seeley DB, Gau JR, Duncan JM, Walker SC, Lewinsohn DD PM (2016) Association of comorbid psychopathology with the duration of cannabis use disorders. Psychol Addict Behav 30(1):82–92

    Article  PubMed  PubMed Central  Google Scholar 

  38. Agrawal A, Budney AJ, Lynskey MT (2012) The co-occurring use and misuse of cannabis and tobacco: a review. Addiction. https://doi.org/10.1111/j.1360-0443.2012.03837.x

    Article  PubMed  PubMed Central  Google Scholar 

  39. Lee DC, Budney AJ, Brunette MF, Hughes JR, Etter JF, Stanger C (2015) Outcomes from a computer-assisted intervention simultaneously targeting cannabis and tobacco use. Drug Alcohol Depend 155:134–140. https://doi.org/10.1016/j.drugalcdep.2015.08.001

    Article  PubMed  PubMed Central  Google Scholar 

  40. Florez-Salamanca L, Secades-Villa R, Hasin DS, Cottler L, Wang S, Grant BF, Blanco C (2013) Probability and predictors of transition from abuse to dependence on alcohol, cannabis, and cocaine: results from the national epidemiologic survey on alcohol and related conditions. Am J Drug Alcohol Abuse 39(3):168–179

    Article  PubMed  PubMed Central  Google Scholar 

  41. Lev-Ran S, Le Foll B, McKenzie K, George TP, Rehm J (2013) Cannabis use and cannabis use disorders among individuals with mental illness. Compr Psychiatry 54(6):589–598

    Article  PubMed  Google Scholar 

  42. Lopez-Quintero C, Pérez de los Cobos J, Hasin DS, Okuda M, Wang S, Grant BF, Blanco C (2011) Probability and predictors of transition from first use to dependence on nicotine, alcohol, cannabis, and cocaine: results of the national epidemiologic survey on alcohol and related conditions (NESARC). Drug Alcohol Depend 115(1–2):120–130. https://doi.org/10.1016/j.drugalcdep.2010.11.004

    Article  PubMed  Google Scholar 

  43. Martins SS, Gorelick DA (2011) Conditional substance abuse and dependence by diagnosis of mood or anxiety disorder or schizophrenia in the U.S. population. Drug Alcohol Depend 119(1–2):28–36

    Article  PubMed  PubMed Central  Google Scholar 

  44. Cheung JT, Mann RE, Ialomiteanu A, Stoduto G, Chan V, Ala-Leppilampi K, Rehm J (2010) Anxiety and mood disorders and cannabis use. Am J Drug Alcohol Abuse 36(2):118–122. https://doi.org/10.3109/00952991003713784

    Article  PubMed  Google Scholar 

  45. Zvolensky MJ, Cougle JR, Johnson KA, Bonn-Miller MO, Bernstein A (2010) Marijuana use and panic psychopathology among a representative sample of adults. Exp Clin Psychopharmacol 18(2):129–134. https://doi.org/10.1037/a0019022

    Article  PubMed  PubMed Central  Google Scholar 

  46. Degenhardt L, Hall W, Lynskey M (2001) The relationship between cannabis use, depression and anxiety among Australian adults: findings from the national survey of mental health and well-being. Soc Psychiatry Psychiatr Epidemiol 36(5):219–227. doi:https://doi.org/10.1007/s001270170052

    Article  CAS  PubMed  Google Scholar 

  47. Stinson FS, Ruan WJ, Pickering R, Grant BF (2006) Cannabis use disorders in the USA: prevalence, correlates and co-morbidity. Psychol Med 36(10):1447–1460. https://doi.org/10.1017/S0033291706008361

    Article  PubMed  Google Scholar 

  48. Borodovsky JT, Budney AJ (2018) Cannabis regulatory science: risk–benefit considerations for mental disorders. Int Rev Psychiatry:1–20. https://doi.org/10.1080/09540261.2018.1454406

  49. Goldenberg M, Reid MW, IsHak WW, Danovitch I (2017) The impact of cannabis and cannabinoids for medical conditions on health-related quality of life: a systematic review and meta-analysis. Drug Alcohol Depend 174:80–90

    Article  CAS  PubMed  Google Scholar 

  50. Montanari L, Guarita B, Mounteney J, Zipfel N, Simon R (2017) Cannabis use among people entering drug treatment in Europe: a growing phenomenon? Eur Addict Res 23(3):113–121

    Article  PubMed  Google Scholar 

  51. SAMHSA (2017) Treatment Episode Data Set (TEDS): 2005–2015. National Admissions to Substance Abuse Treatment Services. BHSIS Series S-91, HHS Publication No. (SMA) 17-5037. Substance Abuse and Mental Health Services Administration, Rockville

    Google Scholar 

  52. SAMSHA (2004) Treatment Episode Data Set 2002 SPSS Data

  53. SAMHSA (2017) Treatment Episode Data Set 2015 SPSS Data

  54. Johnston LD, Miech RA, O’Malley PM, Bachman JG, Schulenberg JE, Patrick ME (2017) Monitoring the Future national survey results on drug use: 1975–2017: Overview, key findings on adolescent drug use. Institute for Social Research, The University of Michigan, Ann Arbor

    Google Scholar 

  55. Wu LT, Zhu H, Mannelli P, Swartz MS (2017) Prevalence and correlates of treatment utilization among adults with cannabis use disorder in the United States. Drug Alcohol Depend 177:153–162

    Article  PubMed  PubMed Central  Google Scholar 

  56. Grant BF, Saha TD, Ruan WJ, Goldstein RB, Chou SP, Jung J, Zhang H, Smith SM, Pickering RP, Huang B, Hasin DS (2016) Epidemiology of DSM-5 drug use disorder: results from the national epidemiologic survey on alcohol and related conditions-III. JAMA Psychiatry 73(1):39–47. https://doi.org/10.1001/jamapsychiatry.2015.2132

    Article  PubMed  PubMed Central  Google Scholar 

  57. Blanco C, Iza M, Rodríguez-Fernández JM, Baca-García E, Wang S, Olfson M (2015) Probability and predictors of treatment-seeking for substance use disorders in the U.S. Drug Alcohol Depend 149:136–144

    Article  PubMed  PubMed Central  Google Scholar 

  58. Gates P, Copeland J, Swift W, Martin G (2012) Barriers and facilitators to cannabis treatment. Drug Alcohol Rev 31(3):311–319. https://doi.org/10.1111/j.1465-3362.2011.00313.x

    Article  PubMed  Google Scholar 

  59. van der Pol P, Liebregts N, de Graaf R, Korf DJ, van den Brink W, van Laar M (2013) Facilitators and barriers in treatment seeking for cannabis dependence. Drug Alcohol Depend 133(2):776–780. https://doi.org/10.1016/j.drugalcdep.2013.08.011

    Article  PubMed  Google Scholar 

  60. Budney AJ, Radonovich KJ, Higgins ST, Wong CJ (1998) Adults seeking treatment for marijuana dependence: a comparison to cocaine-dependent treatment seekers. Exp Clin Psychopharmacol 6(4):419–426

    Article  CAS  PubMed  Google Scholar 

  61. Stephens RS, Babor TF, Kadden R, Miller M (2002) The marijuana treatment project: Rationale, design, and participant characteristics. Addiction 97(S1):109–124

    Article  PubMed  Google Scholar 

  62. Knapp AA, Babbin SF, Budney AJ, Walker DD, Stephens RS, Scherer EA, Stanger C (2018) Psychometric assessment of the marijuana adolescent problem inventory. Addict Behav 79(4):113–119

    Article  PubMed  Google Scholar 

  63. WHO ASSIST Working Group (2002) The alcohol, smoking and substance involvement screening test (ASSIST): development, reliability and feasibility. Addiction 97(9):1183–1194

    Article  Google Scholar 

  64. Legleye S, Karila L, Beck F, Reynaud M (2007) Validation of the CAST, a general population cannabis abuse screening test. J Subst Use 12(4):233–242

    Article  Google Scholar 

  65. Adamson SJ, Kay-Lambkin FJ, Baker AL, Lewin TJ, Thornton L, Kelly BJ, Sellman JD (2010) An improved brief measure of cannabis misuse: the cannabis use disorders identification test-revised (CUDIT-R). Drug Alcohol Depend 110(1–2):137–143. https://doi.org/10.1016/j.drugalcdep.2010.02.017

    Article  PubMed  Google Scholar 

  66. Martin G, Copeland J, Gilmour S, Gates P, Swift W (2006) The adolescent cannabis problems questionnaire (CPQ-A): psychometric properties. Addict Behav 31(12):2238–2248. https://doi.org/10.1016/j.addbeh.2006.03.001

    Article  PubMed  Google Scholar 

  67. Bashford J, Flett R, J. C (2010) The cannabis use problems identification test (CUPIT): development, reliability, concurrent and predictive validity among adolescents and adults. Addiction 105(4):615–625

    Article  PubMed  Google Scholar 

  68. White HR, Labouvie EW, Papadaratsakis V (2005) Changes in substance use during the transition to adulthood: a comparison of college students and their noncollege age peers. J Drug Issues 35(2):281–306

    Article  Google Scholar 

  69. Fernandez-Artamendi S, Fernández-Hermida J, Muñiz-Fernández J, Secades-Villa R, García-Fernández G (2012) Screening of cannabis-related problems among youth: the CPQ-A-S and CAST questionnaires. J Subst Abuse Treat Prev Policy 7(1):13. https://doi.org/10.1186/1747-597x-7-13

    Article  Google Scholar 

  70. Halladay J, Petker T, Fein A, Munn C, MacKillop JJSR (2018) Brief interventions for cannabis use in emerging adults: protocol for a systematic review, meta-analysis, and evidence map. Syst Rev 7(1):106. https://doi.org/10.1186/s13643-018-0772-z

    Article  PubMed  PubMed Central  Google Scholar 

  71. Hughes JR, Naud S, Budney AJ, Fingar JR, Callas PW (2016) Attempts to stop or reduce daily cannabis use: an intensive natural history study. Psychol Addict Behav 30(3):389–397. https://doi.org/10.1037/adb0000155

    Article  PubMed  PubMed Central  Google Scholar 

  72. Hughes JR, Peters EN, Callas PW, Budney AJ, Livingston A (2008) Attempts to stop or reduce marijuana use in non-treatment seekers. Drug Alcohol Depend 97:180–184

    Article  PubMed  PubMed Central  Google Scholar 

  73. Hughes JR, Fingar JR, Budney AJ, Naud S, Helzer JE, Callas PW (2014) Marijuana use and intoxication among daily users: an intensive longitudinal study. Addict Behav 39(10):1464–1470. https://doi.org/10.1016/j.addbeh.2014.05.024

    Article  PubMed  PubMed Central  Google Scholar 

  74. Calabria B, Degenhardt L, Briegleb C, Vos T, Hall W, Lynskey M, Callaghan B, Rana U, McLaren J (2010) Systematic review of prospective studies investigating “remission” from amphetamine, cannabis, cocaine or opioid dependence. Addict Behav 35(8):741–749

    Article  PubMed  Google Scholar 

  75. von Sydow K, Lieb R, Pfister H, Hofler M, Sonntag H, Wittchen H (2001) The natural course of cannabis use, abuse and dependence over four years: a longitudinal community study of adolescents and young adults. Drug Alcohol Depend 64:347–361

    Article  Google Scholar 

  76. Budney AJ, Vandrey R, Fearer SA (2011) Cannabis (marijuana). In: Ruiz P, Strain E (eds) Lowenson & Ruiz’s substance abuse: a comprehensive textbook, 5th edn. Lippincott Williams & Wilkins, Baltimore, pp 214–237

    Google Scholar 

  77. Budney AJ, Vandrey RG, Stanger C (2010) Pharmacological and psychosocial interventions for cannabis use disorders. Rev Bras Psiquiatr 32(Suppl 1):S46–S55

    Article  PubMed  Google Scholar 

  78. Cooper K, Chatters R, Kaltenthaler E, Wong R (2015) Psychological and psychosocial interventions for cannabis cessation in adults: a systematic review short report. Health Technol Assess 19(56):1–130. https://doi.org/10.3310/hta19560

    Article  PubMed  PubMed Central  Google Scholar 

  79. Danovitch I, Gorelick DA (2012) State of the art treatments for cannabis dependence. Psychiatric Clin of N Am 35(2):309–326. https://doi.org/10.1016/j.psc.2012.03.003

    Article  Google Scholar 

  80. Davis ML, Powers MB, Handelsman P, Medina JL, Zvolensky M, Smits JA (2015) Behavioral therapies for treatment-seeking cannabis users: a meta-analysis of randomized controlled trials. Eval Health Prof 38(1):94–114. https://doi.org/10.1177/0163278714529970

    Article  PubMed  Google Scholar 

  81. Gates PJ, Sabioni P, Copeland J, Le Foll B, Gowing L (2016) Psychosocial interventions for cannabis use disorder. Cochrane Database Syst Rev (5):CD005336. https://doi.org/10.1002/14651858.CD005336.pub4

  82. Sherman BJ, McRae-Clark AL (2016) Treatment of cannabis use disorder: current ccience and future outlook. Pharmacotherapy 36(5):511–535. https://doi.org/10.1002/phar.1747

    Article  PubMed  PubMed Central  Google Scholar 

  83. Budney AJ, Stanger C, Knapp AA, Walker DD (2018) Status update on the treatment of cannabis use disorder. In: Winters KC, Sabet KA (eds) Contemporary health issues on marijuana. Oxford University Press, New York, pp 236–255

    Chapter  Google Scholar 

  84. Parmar A, Sarkar S (2017) Brief interventions for cannabis use disorders. Rev Addict Dis Treat 16(2):80–93

    Article  Google Scholar 

  85. Budney AJ, Borodovsky JT, Marsch LA, Knapp AA (In press) Technological innovations in addiction treatment. In: Danovitch I, Mooney L (eds) The Assessment and Treatment of Addiction: Best Practices and New Frontiers. Elsevier

  86. Marsch LA, Carroll KM, Kiluk BD (2014) Technology-based interventions for the treatment and recovery management of substance use disorders: a JSAT special issue. J Subst Abuse Treat 46(1):1–4. https://doi.org/10.1016/j.jsat.2013.08.010

    Article  PubMed  Google Scholar 

  87. Schaub MP, Wenger A, Berg O, Beck T, Stark L, Buehler E, Haug S (2015) A web-based self-help intervention with and without chat counseling to reduce cannabis use in problematic cannabis users: three-arm randomized controlled trial. J Med Internet Res 17(10):e232. https://doi.org/10.2196/jmir.4860

    Article  PubMed  PubMed Central  Google Scholar 

  88. Hogue A, Henderson CE, Ozechowski TJ, Robbins MS (2014) Evidence base on outpatient behavioral treatments for adolescent substance use: updates and recommendations 2007–2013. J Clin Child Adolesc Psychol 43(5):695–720. https://doi.org/10.1080/15374416.2014.915550

    Article  PubMed  Google Scholar 

  89. Simpson AK, Magid V (2016) Cannabis use disorder in adolescence. Child Adolesc Psychiatr Clin N Am 25(3):431–443. https://doi.org/10.1016/j.chc.2016.03.003

    Article  PubMed  Google Scholar 

  90. Stanger C, Lansing AH, Budney AJ (2016) Advances in research on contingency management for adolescent substance use. Child Adolesc Psychiatr Clin N Am 25(4):645–659. https://doi.org/10.1016/j.chc.2016.05.002

    Article  PubMed  PubMed Central  Google Scholar 

  91. Tanner-Smith EE, Wilson SJ, Lipsey MW (2013) The comparative effectiveness of outpatient treatment for adolescent substance abuse: a meta-analysis. J Subst Abuse Treat 44:145–158

    Article  PubMed  Google Scholar 

  92. Waldron HB, Turner CW (2008) Evidence-based psychosocial treatments for adolescent substance abuse. J Clin Child Adolesc Psychol 37(1):238–261. https://doi.org/10.1080/15374410701820133

    Article  PubMed  Google Scholar 

  93. Winters KC, Tanner-Smith EE, Bresani E, Meyers K (2014) Current advances in the treatment of adolescent drug use. Adolesc Health Med Ther 5:199–210. https://doi.org/10.2147/AHMT.S48053

    Article  PubMed  PubMed Central  Google Scholar 

  94. Winters KC, Botzet AM, Fahnhorst T (2011) Advances in adolescent substance abuse treatment. Curr Psychiatry Rep 13(5):416–421. https://doi.org/10.1007/s11920-011-0214-2

    Article  PubMed  PubMed Central  Google Scholar 

  95. Hogue A, Henderson CE, Becker SJ, Knight DK (2018) Evidence base on outpatient behavioral treatments for adolescent substance use, 2014–2017: outcomes, treatment delivery, and promising horizons. J Clin Child Adolesc Psychol 47(4):499–526. https://doi.org/10.1080/15374416.2018.1466307

    Article  PubMed  PubMed Central  Google Scholar 

  96. Liddle HA, Rowe CL, Dakof GA, Ungaro RA, Henderson CE (2004) Early intervention for adolescent substance abuse: pretreatment to posttreatment outcomes of a randomized clinical trial comparing multidimensional family therapy and peer group treatment. J Psychoactive Drugs 36(1):49–63

    Article  PubMed  Google Scholar 

  97. Marsch LA, Borodovsky JT (2016) Technology-based interventions for preventing and treating substance use among youth. Child Adolesc Psychiatric Clin N Am 25(4):755–768. https://doi.org/10.1016/j.chc.2016.06.005

    Article  Google Scholar 

  98. Gorelick DA (2016) Pharmacological treatment of cannabis-related disorders: a narrative review. Curr Pharm Des 22(42):6409–6419. https://doi.org/10.2174/1381612822666160822150822

    Article  CAS  PubMed  Google Scholar 

  99. Gray KM, Sonne SC, McClure EA, Ghitza UE, Matthews AG, McRae-Clark AL, Carroll KM, Potter JS, Wiest K, Mooney LJ, Hasson A, Walsh SL, Lofwall MR, Babalonis S, Lindblad RW, Sparenborg S, Wahle A, King JS, Baker NL, Tomko RL, Haynes LF, Vandrey RG, Levin FR (2017) A randomized placebo-controlled trial of N-acetylcysteine for cannabis use disorder in adults. Drug Alcohol Depend 177:249–257. https://doi.org/10.1016/j.drugalcdep.2017.04.020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Copeland J, Pokorski I (2016) Progress toward pharmacotherapies for cannabis-use disorder: an evidence-based review. Subst Abuse Rehabil 7:41–53. https://doi.org/10.2147/SAR.S89857

    Article  PubMed  PubMed Central  Google Scholar 

  101. Mason BJ, Mustafa A, Filbey F, Brown ES (2016) Novel pharmacotherapeutic interventions for cannabis use disorder. Curr Addict Rep 3(2):214–220

    Article  Google Scholar 

  102. Denis C, Lavie E, Fatseas M, Auriacombe M (2006) Psychotherapeutic interventions for cannabis abuse and/or dependence in outpatient settings. Cochrane Database Syst Rev 3. https://doi.org/10.1002/14651858.CD005336.pub2

  103. Hall W, Lynskey M (2016) Why it is probably too soon to assess the public health effects of legalisation of recreational cannabis use in the USA. Lancet Psychiatry 3(9):900–906

    Article  PubMed  Google Scholar 

  104. Wen H, Hockenberry JM, Druss BG (2018) The effect of medical marijuana laws on marijuana-related attitude and perception among US adolescents and young adults. Prev Sci. https://doi.org/10.1007/s11121-018-0903-8

    Article  Google Scholar 

  105. Hasin DS (2017) US epidemiology of cannabis use and associated problems. Neuropsychopharmacology 43:195. https://doi.org/10.1038/npp.2017.198

    Article  PubMed  PubMed Central  Google Scholar 

  106. Carlini BH, Garrett SB, Harwick RM (2017) Beyond joints and brownies: Marijuana concentrates in the legal landscape of WA State. Int J Drug Policy 42:26–29. https://doi.org/10.1016/j.drugpo.2017.01.004

    Article  PubMed  Google Scholar 

  107. Borodovsky JT, Crosier BS, Lee DC, Sargent JD, Budney AJ (2016) Smoking, vaping, eating: is legalization impacting the way people use cannabis? Int J Drug Policy 36:141–147. https://doi.org/10.1016/j.drugpo.2016.02.022

    Article  PubMed  PubMed Central  Google Scholar 

  108. Vandrey R, Herrmann ES, Mitchell JM, Bigelow GE, Flegel R, LoDico C, Cone EJ (2017) Pharmacokinetic profile of oral cannabis in humans: blood and oral fluid disposition and relation to pharmacodynamic outcomes. J Anal Toxicol 41 1–17. https://doi.org/10.1093/jat/bkx012

    Article  CAS  Google Scholar 

  109. Loflin M, Earleywine M (2014) A new method of cannabis ingestion: the dangers of dabs? Addict Behav 39(10):1430–1433. https://doi.org/10.1016/j.addbeh.2014.05.013

    Article  PubMed  Google Scholar 

  110. Volkow N, Baler R, Compton W, Weiss S (2014) Adverse health effects of marijuana use. N Engl J Med 370(23):2219–2227

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  111. Paul CL, Mee KJ, Judd TM, Walsh RA, Tang A, Penman A, Girgis A (2010) Anywhere, anytime: retail access to tobacco in New South Wales and its potential impact on consumption and quitting. Soc Sci Med 71(4):799–806. https://doi.org/10.1016/j.socscimed.2010.05.011

    Article  PubMed  Google Scholar 

  112. Casswell S, Morojele N, Williams PP, Chaiyasong S, Gordon R, Gray-Philip G, Viet Cuong P, MacKintosh AM, Halliday S, Railton R, Randerson S, Parry CDH (2018) The alcohol environment protocol: a new tool for alcohol policy. Drug Alcohol Rev. https://doi.org/10.1111/dar.12654

    Article  PubMed  PubMed Central  Google Scholar 

  113. Bickel WK, Johnson MW, Koffarnus MN, MacKillop J, Murphy JG (2014) The behavioral economics of substance use disorders: reinforcement pathologies and their repair. Annu Rev Clin Psychol 10:641–677. https://doi.org/10.1146/annurev-clinpsy-032813-153724

    Article  PubMed  PubMed Central  Google Scholar 

  114. Borodovsky JT, Lee DC, Crosier BS, Gabrielli JL, Sargent JD, Budney AJ (2017) U.S. cannabis legalization and use of vaping and edible products among youth. Drug Alcohol Depend 177:299–306. https://doi.org/10.1016/j.drugalcdep.2017.02.017

    Article  PubMed  PubMed Central  Google Scholar 

  115. Lee DC, Crosier BS, Borodovsky JT, Sargent JD, Budney AJ (2016) Online survey characterizing vaporizer use among cannabis users. Drug Alcohol Depend 159:227–233. https://doi.org/10.1016/j.drugalcdep.2015.12.020

    Article  PubMed  Google Scholar 

  116. Borodovsky JT, Budney AJ (2017) Legal cannabis laws, home cultivation, and use of edible cannabis products: a growing relationship? Int J Drug Policy 50:102–110. https://doi.org/10.1016/j.drugpo.2017.09.014

    Article  PubMed  PubMed Central  Google Scholar 

  117. Caulkins JP, Kilmer B, MacCoun RJ, Pacula RL, Reuter PH (2012) Design considerations for legalizing cannabis: lessons inspired by analysis of California’s proposition 19. Addiction 107(5):865–871

    Article  PubMed  Google Scholar 

  118. Pacula RL, Kilmer B, Wagenaar AC, Chaloupka FJ, Caulkins JP (2014) Developing public health regulations for marijuana: lessons from alcohol and tobacco. Am J Public Health 104(6):1021–1028. https://doi.org/10.2105/AJPH.2013.301766

    Article  PubMed  PubMed Central  Google Scholar 

  119. Chaloupka FJ, Straif K, Leon ME (2010) Effectiveness of tax and price policies in tobacco control. Tobacco Control. https://doi.org/10.1136/tc.2010.039982

    Article  PubMed  Google Scholar 

  120. Chaloupka FJ, Cummings KM, Morley CP, Horan JK (2002) Tax, price and cigarette smoking: Evidence from the tobacco documents and implications for tobacco company marketing strategies. Tob Control 11(suppl 1):I62–I72. https://doi.org/10.1136/tc.11.suppl_1.i62

    Article  PubMed  PubMed Central  Google Scholar 

  121. Farrell S, Manning WG, Finch MD (2003) Alcohol dependence and the price of alcoholic beverages. J Health Econ 22(1):117–147

    Article  PubMed  Google Scholar 

  122. DiFranza JR, Wellman RJ, Sargent JD, Weitzman M, Hipple BJ, Winickoff JP, Tobacco Consortium CfCHRotAAoP (2006) Tobacco promotion and the initiation of tobacco use: assessing the evidence for causality. Pediatrics 117(6):e1237–e1248. https://doi.org/10.1542/peds.2005-1817

    Article  PubMed  Google Scholar 

  123. Pechmann C, Knight SJ (2002) An experimental investigation of the joint effects of advertising and peers on adolescents’ beliefs and intentions about cigarette consumption. J Consum Res 29(1):5–19. https://doi.org/10.1086/339918

    Article  Google Scholar 

  124. Landman A, Cortese DK, Glantz S (2008) Tobacco industry sociological programs to influence public beliefs about smoking. Soc Sci Med 66(4):970–981. https://doi.org/10.1016/j.socscimed.2007.11.007

    Article  PubMed  PubMed Central  Google Scholar 

  125. Evans N, Farkas A, Gilpin E, Berry C, Pierce JP (1995) Influence of tobacco marketing and exposure to smokers on adolescent susceptibility to smoking. J Natl Cancer Inst 87(20):1538–1545

    Article  CAS  PubMed  Google Scholar 

  126. Biener L, Siegel M (2000) Tobacco marketing and adolescent smoking: more support for a causal inference. Am J Public Health 90(3):407–411

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  127. DeWit DJ, Adlaf EM, Offord DR, Ogborne AC (2000) Age at first alcohol use: a risk factor for the development of alcohol disorders. Am J Psychiatry 157(5):745–750. https://doi.org/10.1176/appi.ajp.157.5.745

    Article  CAS  PubMed  Google Scholar 

  128. Chen C-Y, O’Brien MS, Anthony JC (2005) Who becomes cannabis dependent soon after onset of use? Epidemiological evidence from the United States: 2000–2001. Drug Alcohol Depend 79:11–22

    Article  PubMed  Google Scholar 

  129. Perkonigg A, Goodwin RD, Fiedler A, Behrendt S, Beesdo K, Lieb R, Wittchen H-U (2008) The natural course of cannabis use, abuse and dependence during the first decades of life. Addiction 103(3):439–449. https://doi.org/10.1111/j.1360-0443.2007.02064.x

    Article  PubMed  Google Scholar 

  130. Swift W, Coffey C, Carlin JB, Degenhardt L, Patton GC (2008) Adolescent cannabis users at 24 years: trajectories to regular weekly use and dependence in young adulthood. Addiction 103(8):1361–1370. https://doi.org/10.1111/j.1360-0443.2008.02246.x

    Article  PubMed  Google Scholar 

  131. Agrawal A, Grant JD, Waldron M, Duncan AE, Scherrer JF, Lynskey MT, Madden PA, Bucholz KK, Heath AC (2006) Risk for initiation of substance use as a function of age of onset of cigarette, alcohol and cannabis use: findings in a midwestern female twin cohort. Prev Med 43(2):125–128. https://doi.org/10.1016/j.ypmed.2006.03.022

    Article  PubMed  Google Scholar 

  132. D’Amico EJ, Miles JNV, Tucker JS (2015) Gateway to curiosity: medical marijuana ads and intention and use during middle school. Psychol Addict Behav 29(3):613–619. https://doi.org/10.1037/adb0000094

    Article  PubMed  PubMed Central  Google Scholar 

  133. Roditis ML, Delucchi K, Chang A, Halpern-Felsher B (2016) Perceptions of social norms and exposure to pro-marijuana messages are associated with adolescent marijuana use. Prev Med 93:171–176. https://doi.org/10.1016/j.ypmed.2016.10.013

    Article  PubMed  PubMed Central  Google Scholar 

  134. Schuermeyer J, Salomonsen-Sautel S, Price RK, Balan S, Thurstone C, Min SJ, Sakai JT (2014) Temporal trends in marijuana attitudes, availability and use in Colorado compared to non-medical marijuana states: 2003-11. Drug Alcohol Depend 140:145–155. https://doi.org/10.1016/j.drugalcdep.2014.04.016

    Article  PubMed  PubMed Central  Google Scholar 

  135. D’Amico EJ, Rodriguez A, Tucker JS, Pedersen ER, Shih RA (2018) Planting the seed for marijuana use: changes in exposure to medical marijuana advertising and subsequent adolescent marijuana use, cognitions, and consequences over seven years. Drug Alcohol Depend 188:385–391. https://doi.org/10.1016/drugalcdep.2018.03.031

    Article  PubMed  PubMed Central  Google Scholar 

  136. Barry RA, Glantz S (2016) A public health framework for legalized retail marijuana based on the US experience: avoiding a new tobacco industry. PLoS Med 13(9):e1002131. https://doi.org/10.1371/journal.pmed.1002131

    Article  PubMed  PubMed Central  Google Scholar 

  137. Caulkins JP, Kilmer B, Kleiman MAR (2016) Marijuana legalization: What everyone needs to know, 2 edn. Oxford University Press, New York. https://doi.org/10.7249/CB525-1

    Book  Google Scholar 

  138. Kilmer B (2014) Policy designs for cannabis legalization: starting with the eight Ps. Am J Drug Alcohol Abuse 40(4):259–261. https://doi.org/10.3109/00952990.2014.894047

    Article  PubMed  Google Scholar 

  139. Richter KP, Levy S (2014) Big marijuana–lessons from big tobacco. N Engl J Med 371(5):399–401. https://doi.org/10.1056/NEJMp1406074

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Alan J. Budney.

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Budney, A.J., Sofis, M.J. & Borodovsky, J.T. An update on cannabis use disorder with comment on the impact of policy related to therapeutic and recreational cannabis use. Eur Arch Psychiatry Clin Neurosci 269, 73–86 (2019). https://doi.org/10.1007/s00406-018-0976-1

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