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Effect of transcranial direct current stimulation on decision making and cognitive flexibility in gambling disorder

  • Ahmet Zihni Soyata
  • Serkan Aksu
  • Adam J. Woods
  • Pınar İşçen
  • Kardelen Türkü Saçar
  • Sacit Karamürsel
Original Paper

Abstract

Decision making and cognitive flexibility are two components of cognitive control that play a critical role in the emergence, persistence, and relapse of gambling disorder. Transcranial direct current stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) has been reported to enhance decision making and cognitive flexibility in healthy volunteers and individuals with addictive disorders. In this triple-blind randomized sham-controlled parallel study, we aimed to determine whether tDCS over DLPFC would modulate decision making and cognitive flexibility in individuals with gambling disorder. Twenty participants with gambling disorder were administered Iowa Gambling Task (IGT) and Wisconsin Card Sorting Test (WCST). Subsequently, participants were administered three every other day sessions of active right anodal /left cathodal tDCS (20 min, 2 mA) or sham stimulation over bilateral DLPFC. WCST and IGT were readministered following the last session. Baseline clinical severity, depression, impulsivity levels, and cognitive performance were similar between groups. TDCS over the DLPFC resulted in more advantageous decision making (F1,16 = 8.128, p = 0.01, ɳp2 =0.33) and better cognitive flexibility (F1,16 =8.782, p = 0.009, ɳp2 = 0.35), representing large effect sizes. The results suggest for the first time that tDCS enhanced decision making and cognitive flexibility in gambling disorder. Therefore, tDCS may be a promising neuromodulation-based therapeutic approach in gambling disorder.

Trial registration: Clinicaltrials.gov NCT03477799.

Keywords

Addictive disorders Gambling disorder Transcranial direct current stimulation Decision making Executive functions Cognitive functions 

Abbreviations

BART

Balloon analog risk task

BDI

Beck depression inventory

BIS-11

Barratt Impulsivity Scale-11

DLPFC

Dorsolateral prefrontal cortex

DSM-5

Diagnostic and statistical manual of mental disorders-5

fMRI

Functional magnetic resonance imaging

GD

Gambling disorder

IGT

Iowa gambling task

PGSI

Pathological Gambling Severity Index

SOGS

South oaks gambling screen

tDCS

Transcranial direct current stimulation

VMPFC

Ventromedial prefrontal cortex

WCST

Wisconsin card sorting test

Notes

Acknowledgements

The authors would like to thank all the participants who have kindly taken part in this study. The authors gratefully acknowledge the assistance of Mustafa Çetinkaya for referring participants and Göktuğ Aşçı for the preparation of the equipment.

Compliance with ethical standards

Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. 1.Department of Psychiatry, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  2. 2.Department of Physiology, Istanbul Faculty of MedicineIstanbul UniversityIstanbulTurkey
  3. 3.Department of Clinical and Health Psychology, Cognitive Aging and Memory Clinical Translational Research Program, Center for Cognitive Aging and Memory, McKnight Brain InstituteUniversity of FloridaGainesvilleUSA
  4. 4.Istanbul Faculty of Medicine, Aziz Sancar Institute of Experimental MedicineIstanbul UniversityIstanbulTurkey
  5. 5.Department of Physiology, Faculty of Medicine IstanbulIstinye UniversityIstanbulTurkey

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