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Erratum to: Further evidence for the association between a polymorphism in the promoter region of SLC6A3/DAT1 and ADHD: findings from a sample of adults

  • Lucas A. de Azeredo
  • Diego L. Rovaris
  • Nina R. Mota
  • Evelise R. Polina
  • Francine Z. Marques
  • Verônica Contini
  • Eduardo S. Vitola
  • Paulo Belmonte-de-Abreu
  • Luis A. Rohde
  • Eugenio H. Grevet
  • Claiton H. D. BauEmail author
Erratum
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Erratum to: Eur Arch Psychiatry Clin Neurosci (2014) 264:401–408 DOI 10.1007/s00406-014-0486-8

Unfortunately, we recently identified a batch effect in PCR readings in which reverse coding for CC and TT genotypes of DAT1 rs2652511 polymorphism was detected. The identification of the CT genotype remained correct. Since the frequency of heterozygotes did not change, the genotype frequencies were in Hardy–Weinberg equilibrium (P > 0.05) in both the original and corrected versions of the article. Importantly, we emphasize that this coding error did not affect the genotyping data of DAT1 VNTR polymorphisms, including the association between the 6-repeat allele of the Int8 VNTR polymorphism and higher inattention scores in patients with ADHD.

We reran our statistical analyses with the corrected genotypes of DAT1 rs2652511 polymorphism. (1) Logistic regression for casecontrol analysis: in contrast to the original paper, the authors found no evidence to support the association between the rs2652511 C-allele and ADHD (Table 2 in the original paper). The correct sentence in the corresponding text in Results section of the original paper would be “We found no significant association between the rs2652511 and ADHD”. An updated version of Table 2 is given. (2) Analysis of covariance (ANCOVA) for SNAP-IV scores: once more, our findings regarding the rs2652511 polymorphism remained non-significant (Table 3 in the original paper). Thus, interpretations and conclusions related to the ADHD dimensions remain unaltered. The corrected P values are as follows: hyperactivity, P = 0.643; inattention, P = 0.482; total sum of ADHD symptoms, P = 0.915; and ODD, P = 0.959.
Table 2

Genotype analyses of the DAT1 polymorphisms 3′-UTR VNTR, Int8 VNTR, and −839 C>T (rs2652511) and haplotype analysis for VNTR polymorphisms on susceptibility to ADHD

Genotypesa

Frequency (%)

Wald P valueb

OR (95 % CI)

DAT1 3′-UTR VNTR

ADHD

(n = 476)

Controls

(n = 587)

.

.

.

 

.

.

.

.

.

.

.

.

.

.

.

DAT1 Int8 VNTR

(n = 497)

(n = 596)

  

.

.

.

 

.

.

.

.

.

.

.

.

.

.

.

DAT1 −839 C>T

(n = 501)

(n = 569)

  

TT

100 (20.0)

98 (17.2)

 

1

TC

241 (48.1)

302 (53.1)

0.240

0.81 (0.58–1.14)

CC

160 (31.9)

169 (29.7)

0.957

0.99 (0.68–1.42)

aOnly the most common genotypes were taken into account in the tests of association with ADHD, and for this reason, sample sizes are smaller than the original 522 adult patients and 628 controls. DAT1 VNTR: the rate of genotypes with rare alleles did not differ between ADHD patients and controls (Fisher’s exact test): 3′-UTR VNTR (2, 3, 6, 7, 8, 11, 12, 13, and 14 repeats) −0.038 and 0.040, respectively (P = 0.878); Int8 VNTR: (4, 7, 13, and 14 repeats) −0.010 and 0.024, respectively (P = 0.074). Considering the rs2652511 SNP, 4 % of patients and 9 % of controls had missing data due to genotype failure

bAdjusted by age and gender

Although this error unfortunately resulted in incorrect assignment of statistical significance to the rs2652511 polymorphism in adult ADHD, our results still support one of the major interpretations and conclusions of this research, particularly regarding the association between the 6-repeat allele of the Int8 VNTR polymorphism and higher scores of inattention in adult patients with ADHD. The authors apologize for any inconvenience that our errors may have caused.

Copyright information

© Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  • Lucas A. de Azeredo
    • 1
    • 2
  • Diego L. Rovaris
    • 1
    • 2
  • Nina R. Mota
    • 1
    • 2
  • Evelise R. Polina
    • 1
    • 2
  • Francine Z. Marques
    • 3
  • Verônica Contini
    • 2
    • 4
  • Eduardo S. Vitola
    • 2
  • Paulo Belmonte-de-Abreu
    • 5
  • Luis A. Rohde
    • 2
    • 5
    • 6
  • Eugenio H. Grevet
    • 2
  • Claiton H. D. Bau
    • 1
    • 2
    Email author
  1. 1.Department of Genetics, Instituto de BiociênciasUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.ADHD Outpatient Program, Adult DivisionHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  3. 3.School of Health SciencesUniversity of BallaratBallaratAustralia
  4. 4.Postgraduate Program in BiotechnologyCentro Universitário UnivatesLajeadoBrazil
  5. 5.Department of Psychiatry, Faculdade de MedicinaUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  6. 6.Instituto de Psiquiatria do Desenvolvimento para a Infância e AdolescênciaSão PauloBrazil

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