References
Powell TR, McGuffin P, D’Souza UM, Cohen-Woods S, Hosang GM, Martin C, Matthews K, Day RK, Farmer AE, Tansey KE, Schalkwyk LC (2014) Putative transcriptional biomarkers in the inflammatory cytokine pathway differentiate major depressive disorder patients from control subjects and bipolar disorder patients. PLoS ONE 9:e91076
Hashimoto K, Shimizu E, Iyo M (2004) Critical role of brain-derived neurotrophic factor in mood disorders. Brain Res Brain Res Rev 45:104–114
Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 64:341–357
Hashimoto K (2013) Sigma-1 receptor chaperone and brain-derived neurotrophic factor: emerging links between cardiovascular disease and depression. Prog Neurobiol 100:15–29
Hashimoto K (2014) Serum brain-derived neurotrophic factor as a predictor of incident dementia. JAMA Neurol 71:653
Hashimoto K (2014) Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF as predictable biomarkers for bipolar disorder. Bri J Psychiatry (in press)
Shimizu E, Hashimoto K, Okamura N, Koike K, Komatsu N, Kumakiri C, Nakazato M, Watanabe H, Shinoda N, Okada S, Iyo M (2003) Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients without or with antidepressants. Biol Psychiatry 54:70–75
Molendijk ML, Spinhoven P, Polak M, Bus BAA, Penninx BW, Elzinga BM (2014) Serum BDNF concentrations as peripheral manifestations of depression: evidence from a systematic review and meta-analyses on 179 associations (N = 9,484). Mol Psychiatry 19:791–800
Yoshida T, Ishikawa M, Iyo M, Hashimoto K (2012) Serum levels of mature brain-derived neurotrophic factor and its precursor proBDNF in healthy subjects. Open Clin Chem J 5:7–12
Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T, Shiina A, Hashimoto T, Kanahara N, Hasegawa T, Enohara M, Kimura A, Iyo M, Hashimoto K (2012) Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS ONE 7:e42676
Södersten K, Pålsson E, Ishima T, Funa K, Landén M, Hashimoto K, Ågren H (2014) Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: a study of two independent cohorts. J Affect Disord 160:1–9
Tunca Z, Ozerdem A, Ceylan D, Yalçın Y, Can G, Resmi H, Akan P, Ergör G, Aydemir O, Cengisiz C, Kerim D (2014) Alterations in BDNF (brain derived neurotrophic factor) and GDNF (glial cell line-derived neurotrophic factor) serum levels in bipolar disorder: The role of lithium. J Affect Disord 166:193–200
Dell’Osso B, D’Addario C, Carlotta Palazzo M, Benatti B, Camuri G, Galimberti D, Fenoglio C, Scarpini E, Di Francesco A, Maccarrone M, Altamura AC (2014) Epigenetic modulation of BDNF gene: differences in DNA methylation between unipolar and bipolar patients. J Affect Disord 166:330–333
Terracciano A, Piras MG, Lobina M, Mulas A, Meirelles O, Sutin AR, Chan W, Sanna S, Uda M, Crisponi L, Schlessinger D (2013) Genetics of serum BDNF: meta-analysis of the Val66Met and genome-wide association study. World J Biol Psychiatry 14:583–589
Acknowledgments
This study was supported by a grant from Comprehensive Research on Disability, Health and Welfare, Health and Labour Sciences Research Grants, Japan.
Conflict of interest
Dr. Hashimoto is a holder of the patents “Diagnostic and examination method for eating disorder” (US 7,754,434 B2) and “Diagnostic agent for ischemic heart disease risk group” (US 2013/0310321A1); which pertain to the measurement of BDNF as a biomarker. In addition, Dr. Hashimoto has served as a scientific consultant to Astellas, Dainippon-Sumitomo and Taisho, and he has also received research support from Abbvie, Dainippon-Sumitomo, Otsuka and Taisho.
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Hashimoto, K. Brain-derived neurotrophic factor (BDNF) and its precursor proBDNF as diagnostic biomarkers for major depressive disorder and bipolar disorder. Eur Arch Psychiatry Clin Neurosci 265, 83–84 (2015). https://doi.org/10.1007/s00406-014-0557-x
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DOI: https://doi.org/10.1007/s00406-014-0557-x